Donor Characteristics That Are Associated With Survival in Liver Transplant Recipients Older Than 70 Years With Grafts

Álamo, J.M.; Olivares, Claudia; Jiménez, Gustavo Guerrero; Bernal, C. Carmona; Marín, Luis Miguel; Tinoco, J.; Suárez, G.; Serrano, Juan Bautista Vivero; Padillo, Javier; Gómez, M. A.

doi:10.1016/j.transproceed.2013.10.031

Cited by 27 publications

(19 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Eight comparative studies reported the outcomes of LT among recipients from donors aged <70 years old and >70 years old. Overall, 4376 LT recipients were included with n = 3497 (79.9%) patients receiving grafts from donors aged <70 years old and 879 (20.1%) receiving grafts from >70‐year‐old donors.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Systematic review and meta‐analysis of liver transplantation using grafts from deceased donors aged over 70 years

Dasari

Mergental

Isaac

et al. 2017

Clinical Transplantation

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

“…Seven studies reported 3‐year and 5‐year graft survival, and six studies reported the 1‐year graft survival rates . Graft survival at 1‐year follow‐up was similar between the two groups (86.3% vs 85.1%) [OR = 1.25, 95% CI = 0.95‐1.65; P = .11, I 2 = 0%].…”

Section: Resultsmentioning

confidence: 99%

Systematic review and meta‐analysis of liver transplantation using grafts from deceased donors aged over 70 years

Dasari

Mergental

Isaac

et al. 2017

Clinical Transplantation

View full text Add to dashboard Cite

show abstract

“…This study is the first study to compare matched recipients of elder donors with those of younger donors to better determine the effects of the elder graft on patient outcomes. Since the first reported case by Wall et al 16 [17][18][19][20][21][22] It is difficult to truly determine the difference in outcomes when simply comparing two cohorts solely based on age of the donor, as most of these studies have done. It is unlikely a difference will be noted between two recipients of a donor only slightly above or below the investigated age cut-off (ie, a recipient of an 80-year-old allograft may be compared to the recipient of a 78-year-old allograft).…”

Section: Discussionmentioning

confidence: 99%

“…[17][18][19][20][21][22] It is difficult to truly determine the difference in outcomes when simply comparing two cohorts solely based on age of the donor, as most of these studies have done. outcomes using elderly donors with great disparity in the periods of follow-up and age of the donor analyzed.…”

Section: De Novo Malignancymentioning

confidence: 99%

Long‐term outcomes of the octogenarian donor liver recipient: The era of the new centurion

Schneider

Jaime

Mara

et al. 2019

Clinical Transplantation

View full text Add to dashboard Cite

Over the last decade, the limited number of deceased donors has resulted in longer waiting times and increased mortality on the waitlist. 1,2 In order to tackle this growing demand and organ shortage, several efforts have been pursued to widen the donor pool. Grafts from living donation, split-liver grafts, donation after circulatory death (DCD), and extended criteria donors (ECDs) including elderly donors are increasingly being used. [3][4][5] The relationship between donor age and LT outcomes has been widely studied, with controversial results. Initial studies reported older donor age as one of the most important negative prognostic factors for patient and graft survival. 6 More recent data, however, confirmed the safety with good short-and medium-term outcomes of these grafts, when recipients were appropriately selected. 1,7 A Abstract Background: Studies have suggested transplantation using older donor livers results in similar short-term outcomes as younger donor livers; however, little data exist on long-term patient/graft outcomes of the octogenarian liver recipient. Methods: Retrospective data were collected from 2 centers, (Valencia, Spain and Rochester, MN, USA) of all recipients of octogenarian donor liver allografts from 2000 to 2011 with follow-up to 2016. The aim was to compare long-term patient/ graft survival as well as metabolic outcomes of the recipient with the octogenarian liver vs younger than 60 years donor.Results: 78 recipients of older liver allografts were compared to 78 matched controls. No difference in 10-year patient mortality was demonstrated (P = 0.074).Octogenarian livers were associated with 3-fold higher likelihood of graft failure (P = 0.002) but no increase in the risk of post-LT cardiovascular disease (P = 0.60), hypertension (P = 0.33), vascular complications (P = 0.53), or malignancy (P = 0.14).In multivariate analysis, elder livers remained a significant factor associated with rejection (P = 0.034) with a trend not reaching statistical significance for graft failure (P = 0.052).Conclusions: For appropriately selected recipients, receiving an octogenarian liver does not clearly influence patient survival but does impact early graft survival with a notable increase in early posttransplant rejection rates and re-transplantation. Over 1.5 decades, older allografts have not adversely affected metabolic outcomes. K E Y W O R D S cardiovascular, donor age, elder, liver transplantation, metabolic, survival 2 of 9 | SCHNEIDER Et al. report from the Scientific Registry of Transplant Recipient (SRTR) data once again questioned the utilization of the older donors,showing increased graft and patient mortality. 8,9 Many factors contribute to patient and graft outcomes, and most of these studies cannot separate outcomes specifically related to the donor organ received.The liver has a significant role in metabolic functions. In liver transplant recipients, the graft becomes the main organ for carbohydrate, protein, lipid, and drug metabolism, responsible for the maintenance of glucose hom...

show abstract

“…In many transplant centers, the wide availability of organ donations from young deceased donors who died due to trauma has all but ended, and the era of elderly potential donors (above 65 years) whose brain death resulted from cardiovascular or cerebrovascular accidents has begun. 6 Although many studies have demonstrated the safety and even advantages of liver transplant from elderly donors when well selected and performed, 6,7 we know that the incidence of a variety of liver diseases increases with age, and the ability of the liver to resist external injuries during and after transplant similarly declines. No organ donation and transplant expert has experienced the demographic changes in donors as much as those in Iran.…”

Section: Introductionmentioning

confidence: 99%

Untitled

Mojtabaee

Shamsaeefar²,

Gholami³

et al. 2017

Exp Clin Transplant

View full text Add to dashboard Cite

Objectives: This study investigated a fixed coordinatordirected donor management strategy's impact on donated liver quality, as determined by definitive biopsy results. Conclusions: Donated liver disqualification before transplant noticeably decreased despite the shift in demographic patterns from 2012 to 2016. In group A, brain-dead liver donors were younger and more often died from trauma, whereas group B donors had more cerebrovascular accident-induced deaths. This achievement took place alongside increased rates of steatosis and decreased rates of necrosis.

show abstract

Donor Characteristics That Are Associated With Survival in Liver Transplant Recipients Older Than 70 Years With Grafts

Cited by 27 publications

References 10 publications

Systematic review and meta‐analysis of liver transplantation using grafts from deceased donors aged over 70 years

Systematic review and meta‐analysis of liver transplantation using grafts from deceased donors aged over 70 years

Long‐term outcomes of the octogenarian donor liver recipient: The era of the new centurion

Untitled

Contact Info

Product

Resources

About