Donor-Derived Long-Term Multilineage Hematopoiesis in a Liver-Transplant Recipient

The characterization of reconstituted passenger leukocytes on the induction of tolerance in rat liver transplantation

“…However, unlike other studies using parking of the liver [27, 291, reconstitution of the irradiated donor with bone marrow cells [31], or injection of cells into the recipient, we reestablished liver-induced tolerance simply by injecting naive donor type spleen cells into the irradiated donor 24 h prior to transplantation [26]. Furthermore, our present study shows that splenic "T-cell-enriched" populations may play an important role in the restoration of liver graft acceptance, although we should further investigate the involvement of radio-resistant dendritic cells [8,29] or intrahepatic hematopoietic stem cells [2,20] in the induction of tolerance. This is consistent with other clinical trials and experimental studies that have shown that donor T cells can play a critical role in preventing allogenic marrow graft rejection [18, 191. In the present study, we show that the effect of TBI and/or reconstitution is specific to liver transplantation and cannot be observed in HHT models in which the same donor is used.…”

Adult Human Liver Contains CD8pos T Cells with Naive Phenotype, but Is Not a Site for Conventional αβ T Cell Development

“…The liver is also a rich source of IL-7 (11), which has been shown to be critical for normal T cell development (12). In addition, extramedullary erythropoiesis in the liver and reconstitution of multilineage hemopoiesis by donor-derived cells in patients with normal bone marrow function have been reported after liver transplantation (13). Finally, normal AHL contains functional stem cells (14 -16), Ͼ50% of which express markers of activation and up to 70% of which are lymphoid progenitors (16).…”

Transference of peanut allergy through liver transplantation

“…Pluripotent hematopoietic donor stem cells are present in the liver and have been transferred from donor to recipient. 5 These donor stem cells are capable of producing lymphocytes that would be sensitized to peanut and potentially capable of eliciting a peanut allergy in the recipient. Second, the liver is larger and more vascular than the kidney and heart, which increases the likelihood of transference of sensitized donor lymphocytes into the transplant recipient.…”