Donor Factors Impacting Human Islet Yield and Their in Vivo Function

Sabek, Omaima; Fraga, Dan; Hathaway, Donna; Kotb, Malak; Gaber, A. Osama

doi:10.1097/00007890-199904150-00567

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2001

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“…Young donors are functionally better than an older donor (e.g. 30 vs. 55 year)[57,59]. Prolonged hospitalization and donor hyperglycaemia (> 10 mmol/l)[56,57,60,61] are also thought to be detrimental to islet yield.…”

Section: Organ Donationmentioning

confidence: 99%

Human islet cell transplantation – future prospects

et al. 2001

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There are many factors which can explain the failure of achieving insulin-independence after islet allotransplantation. These include the use of diabetogenic immunosuppressive agents to abrogate both islet allo-immunity and auto-immunity, the critical islet mass to achieve insulin-independence and the detrimental effects of transplanting islets in an ectopic site. However recent evidence most notably from the Edmonton group demonstrates that islet allotransplantation still has great potential to become an established treatment option for diabetic patients.

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Section: Organ Donationmentioning

confidence: 99%