Donor genetic variants as risk factors for thrombosis after liver transplantation: A genome-wide association study

Abstract

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Donor-derived disorders of hemostasis and thrombosis in liver transplantation: Considerations for deceased donor liver selection

“…In the largest genetic study of liver transplant donors to date involving 775 adult donors and 310 pediatric donors, there was no association between known thrombophilic gene loci and post-transplant thrombosis. This study identified three previously unrecognized genes, AK4 , RGS5 , and ETFA , as being associated with increased risk of post-transplant thrombosis and graft loss, and patient mortality was higher in patients with post-transplant thrombosis 17 …”

“…Outcome of the recipient will depend on the phenotype of the donor rather than the presence of a particular mutation Difficult to speculate the outcome due to difficulties in variant interpretation, heterogenous phenotype among different variants, and incomplete knowledge due to under-reporting of clinical data Li et al [17] single unprovoked thrombotic event, the transplant team could consider using the liver for transplantation.…”

“…This study identified three previously unrecognized genes, AK4, RGS5, and ETFA, as being associated with increased risk of post-transplant thrombosis and graft loss, and patient mortality was higher in patients with post-transplant thrombosis. [17] INHERITED BLEEDING DISORDERS…”

The Impact of Donor and Recipient Genetic Variation on Outcomes After Solid Organ Transplantation: A Scoping Review and Future Perspectives

“…We identified 2 candidate risk loci ( AK4 and RGS5 ) but also found that previously associated thrombophilia risk loci in donors did not increase the thrombosis risk in liver transplant recipients. 44 Another study assessed 4 separate genetic matching scores, which were utilized to calculate differences between transplant donors and recipients, for liver transplant outcomes with robust statistical power. This study showed joint testing could help with detecting SNPs significantly associated with acute rejection in liver transplantation.…”