Donor heart and lung procurement: A consensus statement

Copeland, Hannah; Hayanga, J.W. Awori; Neyrinck, Arne; Macdonald, P.; Dellgren, Göran; Bertolotti, Alejandro; Khuu, T.; Burrows, Fay; Copeland, Jack G.; Gooch, Danyel; Hackmann, Amy E.; Hormuth, David A.; Kirk, Christa Jefferis; Linacre, V.; Lyster, Haifa; Marasco, Silvana; McGiffin, David C.; Nair, Priya; Rahmel, Axel; Sasevich, Michael; Schweiger, Martin; Siddique, Aleem; Snyder, Timothy J.; Stansfield, William E.; Tsui, Steven; Orr, Yishay; Uber, Patricia A.; Venkateswaran, R.; Kukreja, Jasleen; Mulligan, Michael J.

doi:10.1016/j.healun.2020.03.020

Cited by 127 publications

(108 citation statements)

References 76 publications

Supporting

Mentioning

107

Contrasting

Unclassified

Order By: Relevance

“…It has a poor prognosis, and heart transplantation (HT) is the treatment of choice in selected patients (1). When allocating a graft, donor, and recipient characteristics should be considered (2). Among them, the influence of donor/recipient sex-mismatch on prognosis has been broadly discussed.…”

Section: Introductionmentioning

confidence: 99%

Influence of Sex-Mismatch on Prognosis After Heart Transplantation

Ayesta

2021

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

The influence of donor and recipient sex on prognosis after heart transplantation has been analyzed in single, multi-center studies, and international registries. In most of them, sex-mismatch was identified as a risk factor for the worst prognosis, especially in men recipients of female heart. This could be attributed to physiological differences between women and men, differences in complications rates after heart transplantation (rejection, cardiovascular allograft vasculopathy, and primary graft failure), and pulmonary hypertension of the recipient. Confounding variables as age, urgent transplantation, and size-mismatch should also be considered. When allocating a graft, sex-mismatch should be considered but its influence in long-term survival should be further explored.

show abstract

Section: Introductionmentioning

confidence: 99%

Influence of Sex-Mismatch on Prognosis After Heart Transplantation

Ayesta

2021

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

show abstract

“…There are no definitive guidelines for the use of vasoactive therapy in brain dead donors [43]. However, several studies have investigated the effects of different vasoactive therapies on donor heart function.…”

Section: Vasoactive Therapymentioning

confidence: 99%

New Approaches to Donor Selection and Preparation in Heart Transplantation

Tong

Khush

2021

Curr Treat Options Cardio Med

View full text Add to dashboard Cite

Purpose of review With increasing survival of patients with stage D heart failure, the demand for heart transplantation has increased. The supply of donor hearts remains relatively limited. Strategies have been investigated and new technologies have been developed to expand the current donor pool. These new approaches will be discussed herein. Recent findings Donor hearts are often considered "marginal" due to risk factors such as older age, size mismatch with the intended recipient, prolonged ischemic time, presence of left ventricular hypertrophy, and hepatitis B/C infection. We reviewed recent data regarding the use of donor hearts with these risk factors and suggest ways to safely liberalize current donor heart acceptance criteria. New technologies such as temperaturecontrolled transport systems and ex vivo cardiac perfusion methods have also demonstrated promising short-term and intermediate outcomes as compared with routine cold storage, by promoting heart preservation and enabling heart procurement from remote sites with shorter cold ischemic time. Recent use of hearts from donation after circulatory death donors has demonstrated comparable outcomes to conventional donation after brain death, which can further expand the current donor pool. Summary Careful selection of "marginal" donor hearts, use of ex vivo cardiac perfusion, and acceptance of hearts after circulatory death may expand our current cardiac donor pool with comparable outcomes to conventional donor selection and preparation methods.

show abstract

“…For certain circumstances, such as a recipient with complex congenital heart disease who may require reconstruction of the pulmonary arteries, additional tissue may need to be procured either in continuity with the donor heart or separately, such as the descending thoracic aorta or innominate vein. If possible, the PA bifurcation along with the RPA and LPA should be procured if the lungs are not being placed [6].…”

Section: Adult Congenital Heart Disease Recipientsmentioning

confidence: 99%

“…In DCD-what we have is what we get-so we must ascertain the lung status before we head over to the center, which explains why we have more stringent cut-off: to make sure that the lung is acceptable radiologically (CT scan preferred) and physiologically. Bronchoscopy is often done after withdrawal of care (most of the time it is for flushing) and it is done in a rush [6].…”

Section: Donation After Circulatory Death 71 Dcdd-lung Only Procuremmentioning

confidence: 99%

Thoracic Organ Procurement during Multi-Organ Retrieval

Keshavamurthy¹,

Dulam²,

Leotta³

et al. 2021

Organ Donation and Transplantation

View full text Add to dashboard Cite

Procurement of thoracic organs can be divided into two major categories- donation after brain death (DBD) or donation after circulatory determination of death (DCDD). In this section we will focus primarily on DBD, which is the commoner of these two or at times referred to as standard procurement. DCDD is a relatively new and promising field that has helped ameliorate donor shortage, aided by the latest advances in medical technology. However, DBD continues to be the major avenue of organ donation. There are several different combinations of thoracic procurement surgeries: heart, double lung, single lung/ 2-single lungs, heart-lung en bloc for transplantation, Double Lung procurement for Bronchial arterial revascularization, Heart and Lung procurement in DCDD donors with the OCS, NRP or Lungs for EVLP.

show abstract

Donor heart and lung procurement: A consensus statement

Cited by 127 publications

References 76 publications

Influence of Sex-Mismatch on Prognosis After Heart Transplantation

Influence of Sex-Mismatch on Prognosis After Heart Transplantation

New Approaches to Donor Selection and Preparation in Heart Transplantation

Thoracic Organ Procurement during Multi-Organ Retrieval

Contact Info

Product

Resources

About