Donor hearts in the Sydney Heart Bank: reliable control but is it ‘normal’ heart?

Marston, Steven B.; Jacques, Adam; Bayliss, Christopher R.; Dyer, Ellie E.; Memo, Massimiliano; Papadaki, Maria; Messer, Andrew E.

doi:10.1007/s12551-020-00740-2

Cited by 2 publications

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References 22 publications

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confidence: 53%

“…Other groups, such as Marston et al (2020) , also studied this criticism and found similar results. Utilizing control human cardiac tissue samples collected from 1994 to 2011 from the Sydney Heart Bank, Marston et al (2020) conducted in vitro motility and TnI phosphorylation measurements. All donors were brain dead and were organ donors, and while time on life support and cardioplegia varied as well, the in vitro motility measurements and TnI phosphorylation measurements of the samples were similar to each other, no matter what the specific cause of death was.…”

Section: Introductionsupporting

confidence: 53%

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The Case for, and Challenges of, Human Cardiac Tissue in Advancing Phosphoprotein Research

Huang

Janssen

2022

Front. Physiol.

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Cardiovascular disease (CVD) and stroke affect over 92 million Americans and account for nearly 1 out of 3 deaths in the US. The use of animal models in cardiovascular research has led to considerable advances in treatment and in our understanding of the pathophysiology of many CVDs. Still, animals may not fully recapitulate human disease states; species differences have long been postulated to be one of the main reasons for a failure of translation between animals and humans in drug discovery and development. Indeed, it has become increasingly clear over the past few decades that to answer certain biomedical questions, like the physiological mechanisms that go awry in many human CVDs, animal tissues may not always be the best option to use. While human cardiac tissue has long been used for laboratory research, published findings often contradict each other, leading to difficulties in interpretation. Current difficulties in utilizing human cardiac tissue include differences in acquisition time, varying tissue procurement protocols, and the struggle to define a human “control” sample. With the tremendous emphasis on translational research that continues to grow, research studies using human tissues are becoming more common. This mini review will discuss advantages, disadvantages, and considerations of using human cardiac tissue in the study of CVDs, paying specific attention to the study of phosphoproteins.

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Section: Introductionsupporting

confidence: 53%

Section: Introductionsupporting

confidence: 53%

The Case for, and Challenges of, Human Cardiac Tissue in Advancing Phosphoprotein Research

Huang

Janssen

2022

Front. Physiol.

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Biophysics of human anatomy and physiology—a Special Issue in honor of Prof. Cristobal dos Remedios on the occasion of his 80th birthday

Hall

Cooke

2020

Biophys Rev

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In 2001, Cristobal dos Remedios was made Professor of Anatomy (now emeritus) within Australia's highest-ranked university (University of Sydney). For the majority of his career, he has examined the biomechanics and biophysics of human muscle contraction. To coincide with the occasion of his 80 th birthday, this Special Issue has commissioned a collection of review articles from experts exploring biophysical subjects within the general areas of human anatomy and physiology. After introducing the scope and contents of the Issue, we provide a short scientific biography, placing his scientific achievements within the context of the course of his life's developments. Cris dos Remedios has played an important role in the development of biophysical research both within Australia and worldwide. Passionate about research, he has pioneered a number of molecular biophysics methodologies for the investigation of muscle contraction (dos Remedios et al. 1972; dos Remedios and Moens 1995; dos Remedios and Chhabra 2007; Mollova et al. 2013; Montag et al. 2018). Within the cardiac muscle field, he is perhaps best known for establishing the Sydney heart bank-a community-wide resource that consists of a very large sample repository of healthy and diseased patient's hearts that have a full associated medical workup and case history (dos Remedios et al. 2017). This Special Issue is split into two general sections. The first includes a series of Commentaries and Letters that allow the authors to describe their scientific and personal interaction with Cris through the course of his career (Table 1). Contributions have been received from both present and former collaborators as well as students at different stages of their professional and academic progression. The second section involves a collection of scientific review articles associated with Cris's principal research topic, the molecular basis of heart muscle contraction. These review articles include analysis of areas ranging from the molecular, to the tissue level, of study (Table 2). To set the scene and help place these articles in context, this Editorial provides a short history of Prof. dos Remedios's life and research in roughly chronological order 1. Following this Editorial is a personal recollection by Cris reflecting on his life in research (dos Remedios 2020). Immediately after this is the fourth addition to our Biophysical Reviews 'Meet the Editor Series' featuring Assoc. Prof. Joshua Ho (University of Hong Kong)-one of the five Executive Editors (Ho 2020). An interesting family history As science is an international endeavour, it is relatively common to meet people from different countries and cultures. With this said, it would be fair to say that Cris has one of the more exotic cultural pedigrees likely to be encountered. The dos Remedios surname is in fact Portuguese and was inherited from his paternal grandfather Carlos dos

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Donor hearts in the Sydney Heart Bank: reliable control but is it ‘normal’ heart?

Cited by 2 publications

References 22 publications

The Case for, and Challenges of, Human Cardiac Tissue in Advancing Phosphoprotein Research

The Case for, and Challenges of, Human Cardiac Tissue in Advancing Phosphoprotein Research

Biophysics of human anatomy and physiology—a Special Issue in honor of Prof. Cristobal dos Remedios on the occasion of his 80th birthday

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