Donor Recruitment for Fecal Microbiota Transplantation

Paramsothy, Sudarshan; Borody, Thomas J.; Lin, Enmoore; Finlayson, Sarah; Walsh, Alissa J.; Samuel, Douglas B.; Bogaerde, Johan van den; Leong, Rupert W.; Connor, Susan J.; Ng, Watson; Mitchell, Hazel M.; Kaakoush, Nadeem O.; Kamm, Michael A.

doi:10.1097/mib.0000000000000405

Cited by 133 publications

(135 citation statements)

References 34 publications

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“…Although blood donors represent a healthy subset of the general population, more than half of all included blood donors failed the initial pre-screening. The high exclusion rate in our study is similar to that reported by others, 14 , 15 but unlike the previous studies, we excluded donors that presented any forms of allergy and lowered the upper BMI limit to 28 kg/m 2 to further reduce the risk of potential risk factors. 19 Correspondingly, including these parameters markedly increased our pre-screening exclusion rate.…”

Section: Discussionsupporting

confidence: 73%

“…7 , 14 , 15 , 18 Still, the recruitment of eligible feces donors remains challenging. Although blood donors represent a healthy subset of the general population, more than half of all included blood donors failed the initial pre-screening.…”

Section: Discussionmentioning

confidence: 99%

“…19 Correspondingly, including these parameters markedly increased our pre-screening exclusion rate. 14 , 15 …”

Section: Discussionmentioning

confidence: 99%

“…14 , 15 While differences in the recruitment processes between studies limits the comparability of the separate steps, the recruitment steps themselves may be an important factor in increasing the number of donors who pass the later screening steps. The electronic pre-screening in our stepwise screening process rapidly ensured that the donors fulfilled all inclusion criteria and were preliminarily assessed for any influential gastrointestinal symptoms before the blood and fecal screenings were conducted.…”

Section: Discussionmentioning

confidence: 99%

“…14 , 15 In studies that advertised study recruitment to the local community, only 6–10% of the volunteers were able to meet all screening criteria. 7 , 14 , 15 This makes sustaining FMT a time-consuming process and calls for methods to identify eligible donors with a high probability of passing the screening tests. Blood donors represent an ideal, healthy subset of the general population because donating blood requires them to meet strict health and lifestyle criteria that are similar to those applied to feces donors.…”

Section: Introductionmentioning

confidence: 99%

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Recruitment of feces donors among blood donors: Results from an observational cohort study

et al. 2018

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As the use of fecal microbiota transplantation (FMT) has gained momentum, an increasing need for continuous access to healthy feces donors has developed. Blood donors constitute a healthy subset of the general population and may serve as an appropriate group for recruitment. In this study, we investigated the suitability of blood donors as feces donors. In a prospective cohort study, we recruited blood donors onsite at a public Danish blood bank. Following their consent, the blood donors underwent a stepwise screening process: First, blood donors completed an electronic pre-screening questionnaire to rule out predisposing risk factors. Second, eligible blood donors had blood and fecal samples examined. Of 155 blood donors asked to participate, 137 (88%) completed the electronic pre-screening questionnaire, 16 declined, and 2 were excluded. Of the 137 donors who completed the questionnaire, 79 (58%) were excluded mainly due to having an allergy, being overweight, or presenting gastrointestinal complaints. Among the remaining 58 (37%) donors, complete blood and feces screenings were obtained from 46 (79%). Of these 46 donors, 15 (33%) were excluded primarily due to abnormal blood results or the presence of apathogenic intestinal parasites. Overall, 31 (20%; 95% confidence interval 14–27%) of the 155 blood donors qualified as feces donors. In conclusion, blood donors constitute a suitable and motivated population for a continuous recruitment of voluntary feces donors. We found that a stepwise recruitment procedure was feasible and that 20% of the blood donors were eligible for feces donation.

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Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 99%

“…19 Correspondingly, including these parameters markedly increased our pre-screening exclusion rate. 14 , 15 …”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Recruitment of feces donors among blood donors: Results from an observational cohort study

et al. 2018

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Ethical Issues of Human Microbiome Research

2021

Encyclopedia of Life Sciences

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Recent years have witnessed an unprecedented explosion of knowledge in human microbiome research. Research on ‘our second genome’ will inevitably bring about dramatic changes in understanding of health and disease and shifts in the paradigm of managing clinical practice and public health interventions. We provide a state‐of‐the‐art overview of these challenges that relate to the broader ethical, legal and social aspects of human microbiome research as well as clinical applications. We focused on (1) human microbiome and personal identity; (2) risks, safety and privacy; (3) informed consent in microbiome‐based interventions; (4) biobanks; (5) commercialisation and hype and (6) public health implications. We hope to contribute to the healthy and sustainable progression of human microbiome research and promote dialogues between scientists, healthcare professionals and the general public. These ethical problems must be addressed as part of a successful regulatory response to emerging studies and translations of this area. Key Concepts Human microbiome research is the leading edge of scientific research. Human microbiome research contributes to health and disease but is still at its infancy. The unique risks and privacy protection of human microbial research should draw attention. Ownership and return of research results problem are even more complex with human microbiome biobanking. Overhype and commercialisation of human microbiome research not only cause risk to individuals but also cause a backlash effect against legitimate treatment. Urgent need to find a balance among the marketplace, scientific research and the public's health.

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Donors' experiences and attitudes of fecal microbiota transplantation: An empirical bioethics study from China

Li³

et al. 2022

iMeta

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Donor participation is a critical part of ensuring the development of human microbiome research and the clinical application of fecal microbiota transplantation (FMT). Most FMT donors are still not sufficiently aware of the risks associated with the act of donating gut microbiota, especially the risk of data privacy disclosure. Enhanced awareness of the moral responsibility of the researchers and ethical oversight by ethics committees are needed.

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Donor Recruitment for Fecal Microbiota Transplantation

Cited by 133 publications

References 34 publications

Recruitment of feces donors among blood donors: Results from an observational cohort study

Recruitment of feces donors among blood donors: Results from an observational cohort study

Ethical Issues of Human Microbiome Research

Donors' experiences and attitudes of fecal microbiota transplantation: An empirical bioethics study from China

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