Donor Safety in Living Donor Liver Transplantation: A Single-Center Analysis of 300 Cases

Abstract

AimTo evaluate the safety to donors of living-donor liver transplantation.MethodsThis study included 300 consecutive living liver tissue donors who underwent operations at our center from July 2002 to December 2012. We evaluated the safety of donors with regard to three aspects complications were recorded prospectively and stratified by grade according to Clavien’s classification, and the data were compared in two stages (the first 5 years’ experience (pre-January 2008) and the latter 5 years’ experience (post-January 2008); laboratory tests such as liver function and blood biochemistry were performed; and the health-related quality of life was evaluated.ResultsThere was no donor mortality at our center, and the overall morbidity rate was 25.3%. Most of the complications of living donors were either grade I or II. There were significantly fewer complications in the latter period of our study than in the initial period (19.9% vs 32.6%, P<0.001), and biliary complications were the most common complications, with an incidence of 9%. All of the liver dysfunction was temporary; however, the post-operative suppression of platelet count lasted for years. Although within the normal range, eight years after operation, 22 donors showed lower platelet levels (189×109/L) compared with the pre-operative levels (267×109/L) (P<0.05). A total of 98.4% of donors had returned to their previous levels of social activity and work, and 99.2% of donors would donate again if it was required and feasible. With the exception of two donors who experienced grade III complications (whose recipients died) and a few cases of abdominal discomfort, fatigue, chronic pain and scar itching, none of the living donors were affected by physical problems.ConclusionWith careful donor selection and specialized patient care, low morbidity rates and satisfactory long-term recovery can be achieved after hepatectomy for living-donor liver transplantation.

Novel techniques and preliminary results of ex vivo liver resection and autotransplantation for end-stage hepatic alveolar echinococcosis: A study of 31 cases

“…Parenchymal transection was performed with a minimum 1.0‐cm lesion‐free margin using the Cavi‐Pulse Ultrasonic Surgical Aspirator (CUSA, Valleylab, Boulder, CO). The procedure for the parenchyma transaction was similar to that of liver graft harvesting from living donors, which was introduced in our previous studies 24, 25. Notably, the left hepatic vein (HV), hepatic artery (HA), hepatic bile duct (HD), and the PV were carefully protected for subsequent reconstruction (Figure 1E).…”

Effects of Different Positive End-Expiratory Pressure Values on Liver Function and Indocyanine Green Clearance Test in Liver Transplantation Donors: A Prospective, Randomized, Double-Blind Study

“…Although AST and ALT peaked on the first postoperative day in routine liver tests, bilirubin reached peak level on day 3 and it took 30 days to return to normal with PT. Lei et al [13] showed similar changes in liver tests in liver transplant donors. In our study, we followed liver test results for 3 days.…”

Quality of Life of related liver donors in the late postoperative period

“…Результаты физического параметра и психологи ческого параметра настоящего исследования были схожи с данными зарубежных коллег [5][6][7][8][9][10], что подтверждает высокую безопасность для прижиз ненного донора операции резекции фрагмента пе чени в целях последующей трансплантации реци пиенту и эффективность опросника SF36 в оценке качества жизни родственных доноров фрагмента печени.…”