Donor Skeletal Muscle Quality Affects Graft Mortality After Living Donor Liver Transplantation- A Single Center, Retrospective Study

Tomiyama, Takeshi; Harada, Noboru; Toshima, Takeo; Nakayama, Yuki; Toshida, Katsuya; Morinaga, Akinari; Kosai‐Fujimoto, Yukiko; Tomino, Takahiro; Kurihara, Toshio; Takeishi, Kazuki; Nagao, Yuhei; Morita, Kazutoyo; Itoh, Shinji; Yoshizumi, Tomoharu

doi:10.3389/ti.2022.10723

Cited by 3 publications

(2 citation statements)

References 33 publications

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“…21 High IMAC reflects both increased intramuscular adipose tissue and loss of muscle mass and is associated with postoperative complications and poor outcomes. 22,23 Although the biological mechanisms underlying the relationship between IMAC and postoperative dysphagia are not yet known, IMAC is a crucial component of sarcopenia and can be easily measured by CT even in emergency situations.…”

Section: Discussionmentioning

confidence: 99%

“…However, the PMI may not reflect actual muscle mass because myosteatosis (skeletal muscle fat infiltration) increases with aging through leptin signaling, fibro‐adipogenic precursor cells, and mitochondrial dysfunction 21 . High IMAC reflects both increased intramuscular adipose tissue and loss of muscle mass and is associated with postoperative complications and poor outcomes 22,23 . Although the biological mechanisms underlying the relationship between IMAC and postoperative dysphagia are not yet known, IMAC is a crucial component of sarcopenia and can be easily measured by CT even in emergency situations.…”

Section: Discussionmentioning

confidence: 99%

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Development of predictive score for postoperative dysphagia after emergency abdominal surgery in patients of advanced age

Iguchi

Mita

Iseda

et al. 2023

Annals of Gastroent Surgery

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AimPostoperative dysphagia after emergency abdominal surgery (EAS) in patients of advanced age has become problematic, and appropriate dysphagia management is needed. This study was performed to identify predictive factors of dysphagia after EAS and to explore the usefulness of swallowing screening tools (SSTs).MethodsThis retrospective study included 267 patients of advanced age who underwent EAS from 2012 to 2022. They were assigned to a dysphagia group and non‐dysphagia group using the Food Intake Level Scale (FILS) (dysphagia was defined as a FILS level of <7 on postoperative day 10). From 2018, original SSTs including a modified water swallowing test were performed by nurses.ResultsThe incidence of postoperative dysphagia was 22.8% (61/267). Patients were significantly older in the dysphagia than non‐dysphagia group. The proportions of patients who had poor nutrition, cerebrovascular disorder, Parkinson's disease, dementia, nursing‐care service, high intramuscular adipose tissue content (IMAC), and postoperative ventilator management were much higher in the dysphagia than non‐dysphagia group. Using logistic regression analysis, high IMAC, postoperative ventilator management, cerebrovascular disorder, and dementia were correlated with postoperative dysphagia and were assigned 10, 4, 3, and 3 points, respectively, according to each odds ratio. The optimal cut‐off value was 7 according to a receiver operating characteristics curve. Using 1:1 propensity score matching for high‐risk patients, the incidence of postoperative dysphagia was reduced by SSTs.ConclusionsThe new prediction score obtained from this study can identify older patients at high risk for dysphagia after EAS, and SSTs may improve these patients' short‐term outcomes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Development of predictive score for postoperative dysphagia after emergency abdominal surgery in patients of advanced age

Iguchi

Mita

Iseda

et al. 2023

Annals of Gastroent Surgery

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Impact of electrical muscle stimulation on serum myostatin level and maintenance of skeletal muscle mass in patients undergoing living‐donor liver transplantation: Single‐center controlled trial

Tsutsui,

Itoh,

Toshima

et al. 2024

Hepatology Research

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AimSarcopenia is reportedly associated with a poor prognosis in patients who undergo living‐donor liver transplantation (LDLT), most of whom are not able to tolerate muscle strengthening exercise training. Myostatin is one of the myokines and a negative regulator of skeletal muscle growth. The clinical feasibility of an electrical muscle stimulation (EMS) system, which exercises muscle automatically by direct electrical stimulation, has been reported. In this study, we aimed to determine the effect of perioperative application of SIXPAD, which is a type of EMS system, with reference to the serum myostatin and sarcopenia in LDLT patients.MethodThirty patients scheduled for LDLT were divided into a SIXPAD group (n = 16) and a control group (n = 14). In the SIXPAD group, EMS was applied to the thighs twice daily. The serum myostatin was measured in samples obtained before use of SIXPAD and immediately before LDLT. The psoas muscle index (PMI) at the level of the third lumbar vertebra and the quadriceps muscle area were compared on computed tomography images before use of SIXPAD and 1 month after LDLT.ResultsThe preoperative serum myostatin was found to be higher in LDLT patients than in healthy volunteers and EMS significantly reduced the serum myostatin. Electrical muscle stimulation prevented a postoperative reduction not only in the area of the quadriceps muscles but also in the PMI despite direct stimulation of the thigh muscles.ConclusionStimulation of muscles by EMS decreases the serum myostatin and helps to maintain skeletal muscle in patients who have undergone LDLT.

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Analyzing body composition in living kidney donors: impact on post-transplant kidney function

Quint,

Westenberg,

Nieuwenhuijs-Moeke

et al. 2024

Front. Nephrol.

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Living donor kidney transplantation boasts superior patient and graft survival rates compared to deceased donor kidney transplantation. However, the impact of living donor body composition (BC) on post-transplant kidney function remains uncertain. In a cohort of 293 living kidney donor-recipients pairs, we utilized linear mixed model analyses, adjusted for time and including a multiplicative interaction term of time with the donor body composition measure, and found no significant associations between any donor BC measure and the annual change in recipient post-transplantation estimated glomerular filtration rate (eGFR) [donor body mass index (BMI): B=-0.01, 95%CI -0.13; 0.11, p=0.88; donor waist circumference: B=0.02, 95%CI -0.02; 0.06, p=0.38; donor skeletal muscle index: B=-0.02, 95%CI -0.07; 0.04, p=0.63; donor skeletal muscle radiation attenuation: B=-0.002, 95%CI -0.06; 0.06, p=0.96; donor visceral adipose tissue index: B=-0.001, 95%CI -0.02; 0.02, p=0.93; donor subcutaneous adipose tissue index: B=-0.001, 95%CI -0.02; 0.02, p=0.94; donor intramuscular adipose tissue index: B=-0.12, 95%CI -0.29; 0.06, p=0.19; donor total abdominal adipose tissue index: B=-0.001, 95%CI -0.01; 0.01, p=0.89]. Our study suggests that pre-donation BC does not affect post-transplantation recipient eGFR in donor populations with a BMI below 35 kg/m2.

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Donor Skeletal Muscle Quality Affects Graft Mortality After Living Donor Liver Transplantation- A Single Center, Retrospective Study

Cited by 3 publications

References 33 publications

Development of predictive score for postoperative dysphagia after emergency abdominal surgery in patients of advanced age

Development of predictive score for postoperative dysphagia after emergency abdominal surgery in patients of advanced age

Impact of electrical muscle stimulation on serum myostatin level and maintenance of skeletal muscle mass in patients undergoing living‐donor liver transplantation: Single‐center controlled trial

Analyzing body composition in living kidney donors: impact on post-transplant kidney function

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