2015
DOI: 10.1097/tp.0000000000000310
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Donor-Specific Antibodies, C4d and Their Relationship With the Prognosis of Transplant Glomerulopathy

Abstract: Transplant glomerulopathy is associated with poor prognosis, independent of the level of graft dysfunction and other chronic histologic changes. This prognosis is similar whether there is evidence of tissue or peripheral alloantibody reactivity. These findings are relevant to the development of clinically meaningful criteria for CAABMR, for its clinical management, and in the future selection of population for clinical trials.

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Cited by 41 publications
(46 citation statements)
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“…In the current study, evolution of cg correlated with dnDSA and time posttransplant, confirming the relationship already reported (35,36). Moreover, though infrequent at the time of dnDSA detection, cg is a strong predictor of subsequent graft loss as reported by others using protocol or for-cause biopsies (28,37,38). In contrast, Einecke et al (39) reported that ci and g, but not cg, were independent predictors of graft loss.…”
Section: Post-dndsa Clinical Histologic Progressionsupporting
confidence: 38%
“…In the current study, evolution of cg correlated with dnDSA and time posttransplant, confirming the relationship already reported (35,36). Moreover, though infrequent at the time of dnDSA detection, cg is a strong predictor of subsequent graft loss as reported by others using protocol or for-cause biopsies (28,37,38). In contrast, Einecke et al (39) reported that ci and g, but not cg, were independent predictors of graft loss.…”
Section: Post-dndsa Clinical Histologic Progressionsupporting
confidence: 38%
“…Obligatory glomerular capillary loop duplication as corroborated by light microscopy and/or electron microscopy defines TG histologically. Previous studies [3,4] have suggested that a diagnosis of TG bears dismal prognosis; however, it has to be emphasized that disease progression in TG is extremely variable with disparate graft survival. Both clinical and histologic factors could sig-nificantly influence long-term allograft survival in TG patients.…”
Section: Introductionmentioning
confidence: 99%
“…В нашем исследовании 9,4% пациентов с ХОТ не имели АТ к HLA и экспрессии С4d в ПТК. Во всех этих случаях лишь тщательное динамическое на-блюдение пациентов, а у некоторых и проведение повторных биопсий трансплантата позволили вери-фицировать диагноз [37,42,43].…”
Section: Discussionunclassified