Donor-transmitted coronary atherosclerosis

A new carotid artery transplantation model of rats

“…Pathologically, the chronic graft loss is characterized by diffuse centripetal thickening and occlusion of arterioles and peri-vascular inflammatory reaction and fibrosis. The mechanisms of the events are not fully understood and might be the result of more than one factor working together, such as ischemia/perfusion injury, rejection against allogenetic antigens, humoral immue response, viral infection, hyperlipoidemia and so on [8][9][10] . To address these problems, a good many research teams have been conducting fundamental studies concerning the chronic rejection, and establishment of animal models of chronic rejection is critical.…”

The effect of a donor's history of active substance on outcomes following orthotopic heart transplantation☆

“…Extended donor criteria are aimed at increasing the donor pool by using marginal donors who would under conventional transplant guidelines be declined as potential organ donors. In heart transplantation, these donors include older aged donors [3][4][5][6][7][8], patients with a history of coronary artery disease [9][10][11][12], patients with a history of viral infection (i.e. hepatitis B or hepatitis C) [2,13,14], and patients with a social history of substance abuse [15][16][17][18].…”

Avaliação da doença vascular do enxerto no transplante cardíaco: experiência de um centro brasileiro

“…In our population, the mean extension of the lesions assessed on IVUS was 14.039 mm, that is, more diffuse lesions than the focal pattern of the lesions associated with atherosclerosis. Studies have suggested that the site in which a concentric atherosclerotic lesion already exists differ from those where lesions associated with CAV occur [21][22][23][24][25][26][27][28] , which does not prevent the existence of both in the same vessel. This could justify the finding of extensive and proximal lesions in our population.…”