Donor Y chromosome in renal carcinoma cells of a female BMT recipient: visualization of putative BMT–tumor hybrids by FISH

Yilmaz, Yesim; Lazova, Rossitza; Qumsiyeh, Mazin B.; Cooper, Dennis; Pawelek, John M.

doi:10.1038/sj.bmt.1704939

Cited by 113 publications

(128 citation statements)

References 15 publications

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“…5 Even though normal tissue chimerism after BMCs transplantation is a real phenomenon, 12,13 the significance of BMCs in human nonhematologic malignancies has been contradictory, probably reflecting the use of different technologies with unsatisfactory stringency to clarify this issue. [6][7][8][9] Tissue injury is reported to enhance the chances of BMCs contributing to non-hematopoietic tissues 2,4,14 by creating a favorable environment for the crossing of lineage barriers. As the neoplastic microenvironment is characterized by apoptosis or necrosis, and proliferation, 1,3 we might expect higher rates of donor-derived cells in carcinomas compared with the normal counterparts.…”

Section: Discussionmentioning

confidence: 99%

“…5 Whether BMCs participate in the formation of solid neoplasms in humans remains unclear. Previous studies yielded conflicting results, [6][7][8][9] probably because of different technical approaches and the use of inadequately rigorous methods. Therefore, carcinomas and adjacent non-neoplastic tissues from female recipients of HLAmatched, sex-mismatched BM cells were analyzed for the presence of genetic material from the male donor by combining FISH with immunofluorescence labeling, and by the examination of the specimens with confocal microscopy.…”

Section: Introductionmentioning

confidence: 99%

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BM-derived cells randomly contribute to neoplastic and non-neoplastic epithelial tissues at low rates

Soldini

Moreno

Martin

et al. 2008

Bone Marrow Transplant

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Epithelial cancers can arise from BM-derived cells (BMCs) in animal models. We studied whether the same phenomenon can occur in humans. Biopsy specimens from carcinomas and healthy adjacent tissues were obtained from three women who had undergone allogeneic BMT from an HLA-matched brother. Complete donor hematopoietic chimerism was verified by cytogenetic analysis, RFLP analysis or by reverse transcription-PCR analysis. Biopsies were studied for the presence of the Y chromosome derived from BM-derived cells by combined FISH and immunohistochemical staining. In our studies, we showed that human epithelial neoplastic and adjacent nonneoplastic tissues incorporate the Y chromosome at low and comparable rates. The lack of enrichment in malignancies argues against the possibility that BMderived cells represent a direct source of carcinomas, and we suggest that these cells randomly contribute to neoplastic and non-neoplastic epithelial cells. On the basis of the absence of a fusion karyotype, we favor a model in which the differentiation of BM-derived cells is largely determined by the microenvironment encountered.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

BM-derived cells randomly contribute to neoplastic and non-neoplastic epithelial tissues at low rates

Soldini

Moreno

Martin

et al. 2008

Bone Marrow Transplant

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“…Fusion events in human cancers, however, are difficult to detect in the clinical context due to the lack of safe tracing methods. Pawelek and co-workers reported evidence indicating fusion in two patients who developed renal-cell carcinoma after allogeneic bone-marrow transplantation from donors of the opposite gender [24,25].…”

Section: Introductionmentioning

confidence: 99%

Macrophage Infiltration in Tumor Stroma is Related to Tumor Cell Expression of CD163 in Colorectal Cancer

Shabo

Olsson

Elkarim

et al. 2014

Cancer Microenvironment

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The scavenger receptor, CD163, is a macrophagespecific marker. Recent studies have shown that CD163 expression in breast and rectal cancer cells is associated with poor prognosis. This study was conducted to evaluate the relationship between CD163 expression as a macrophage trait in cancer cells, and macrophage infiltration and its clinical significance in colorectal cancer. Immunostaining of CD163 and macrophage infiltration were evaluated in paraffinembedded specimens, earlier analyzed for CD31, D2-40 and S-phase fraction, from primary tumors and normal colorectal mucosa of 75 patients with colorectal carcinoma. The outcomes were analyzed in relation to clinical-pathological data. CD163 expression was positive in cancer cells in 20 % of colorectal cancer patients and was related to advanced tumor stages (P=0.008) and unfavorable prognosis (p=0.001). High macrophage infiltration was related to shorter survival and positive CD163 expression in tumor cells. The prognostic impact of macrophage infiltration was independent of tumor stage and CD163 expression in cancer cells (p=0.034). The expression of macrophage phenotype in colorectal cancer cells is associated with macrophage density in tumor stroma and lower survival rates. Macrophage infiltration has an independent prognostic impact on mortality in colorectal cancer. In accordance with previous experimental studies, these findings provide new insights into the role of macrophages in colorectal cancer.

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“…therapeutic effect on liver injury in a rat model [50]. They had the potential to transform into fibrogenic liver cells [51] and may be involved in the development of cancer [52]. However, MSCs derived from the umbilical cord had shown therapeutic potential in a rat model of liver fibrosis [53].…”

Section: Discussionmentioning

confidence: 99%

Antifibrotic Activity of Human Placental Amnion Membrane-Derived CD34+ Mesenchymal Stem/Progenitor Cell Transplantation in Mice With Thioacetamide-Induced Liver Injury

Lee

Hsiao

et al. 2016

Stem Cells Translational Medicine

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Donor Y chromosome in renal carcinoma cells of a female BMT recipient: visualization of putative BMT–tumor hybrids by FISH

Cited by 113 publications

References 15 publications

BM-derived cells randomly contribute to neoplastic and non-neoplastic epithelial tissues at low rates

BM-derived cells randomly contribute to neoplastic and non-neoplastic epithelial tissues at low rates

Macrophage Infiltration in Tumor Stroma is Related to Tumor Cell Expression of CD163 in Colorectal Cancer

Antifibrotic Activity of Human Placental Amnion Membrane-Derived CD34+ Mesenchymal Stem/Progenitor Cell Transplantation in Mice With Thioacetamide-Induced Liver Injury

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