Donors With Familial Hypercholesterolemia and Clinical Outcome in Liver Transplant Recipients.

Gilroy, Richard; Heronemus, M.; Schmitt, Timothy M.; Moriarty, Patrick M.

doi:10.1097/00007890-201407151-02729

Transplantation

2014

DOI: 10.1097/00007890-201407151-02729

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Donors With Familial Hypercholesterolemia and Clinical Outcome in Liver Transplant Recipients.

Richard Gilroy

M. Heronemus

Timothy M. Schmitt

et al.

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2024

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Transplantation of heterozygous familial hypercholesterolemia living donor liver resulting in early myocardial infarction: a possible dangerous link

Kholaif,

Batha,

Elmahi

et al. 2024

Monaldi Arch Chest Dis

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Living donor liver transplantation (LDLT) is a lifesaving procedure that is often curative for several liver diseases. Familial hypercholesterolemia (FH) is a metabolic disease that results from an autosomal dominant mutation in the low-density lipoprotein receptor; yet, young patients with FH can live years without detection. Herein, we report a case of a patient who developed early myocardial infarction (MI) after having a transplant from a donor with undetected heterozygous FH. This was a 67-year-old female with non-alcoholic steatohepatitis-related liver cirrhosis, free from coronary artery disease, who underwent LDLT from her daughter, a 45-year-old female with no past medical history. One year post-transplant, she presented with an acute MI with a large atherosclerotic burden. Genetic analysis confirmed heterozygous FH in the donor but not in the recipient. This case emphasizes the importance of incorporating a thorough clinical history and lipid profile into pre-transplant testing for both the recipient and donor, as well as aggressive lipid-lowering therapy post-transplantation to avoid cardiovascular complications.

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Transplantation of heterozygous familial hypercholesterolemia living donor liver resulting in early myocardial infarction: a possible dangerous link

Kholaif,

Batha,

Elmahi

et al. 2024

Monaldi Arch Chest Dis

View full text Add to dashboard Cite

show abstract

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Donors With Familial Hypercholesterolemia and Clinical Outcome in Liver Transplant Recipients.

Cited by 1 publication

References 0 publications

Transplantation of heterozygous familial hypercholesterolemia living donor liver resulting in early myocardial infarction: a possible dangerous link

Transplantation of heterozygous familial hypercholesterolemia living donor liver resulting in early myocardial infarction: a possible dangerous link

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