1987
DOI: 10.1212/wnl.37.11.1765
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Dopamine agonist therapy for neglect in humans

Abstract: Lesions of ascending dopaminergic pathways induce neglect in animals. Apomorphine, a dopamine receptor agonist, decreases the magnitude of neglect in rats with cortical lesions. We treated two patients with 15 mg of bromocriptine daily for 3 to 4 weeks, one with chronic (longer than 6 months) and one with relatively more acute disabling neglect. Tests for neglect that significantly improved on therapy and worsened after its withdrawal included line, letter, and geometric figure cancellation tasks. Neither pati… Show more

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Cited by 173 publications
(71 citation statements)
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“…Since increased expression of DAT, associated for example with the 3 0 -UTR VNTR, may result in lowered dopamine signalling, our results are consistent with reports that spatial bias is induced by agents that attenuate catecholamine transmission. 13 Further, our findings are consistent with reports that persistent left-neglect can be ameliorated by treatment with dopamine agonists 11 (but see Grujic et al 12 ). Our behavioural data imply that DAT expression might vary between the hemispheres, as a function of DAT1 alleles, being higher in the right hemisphere of individuals carrying risk variants (10/3-repeats).…”
Section: Discussionsupporting
confidence: 92%
See 1 more Smart Citation
“…Since increased expression of DAT, associated for example with the 3 0 -UTR VNTR, may result in lowered dopamine signalling, our results are consistent with reports that spatial bias is induced by agents that attenuate catecholamine transmission. 13 Further, our findings are consistent with reports that persistent left-neglect can be ameliorated by treatment with dopamine agonists 11 (but see Grujic et al 12 ). Our behavioural data imply that DAT expression might vary between the hemispheres, as a function of DAT1 alleles, being higher in the right hemisphere of individuals carrying risk variants (10/3-repeats).…”
Section: Discussionsupporting
confidence: 92%
“…Yet there are good reasons to expect that dopamine may play an important role in directed attention, particularly across the hemifields. Lesions of the ascending dopaminergic pathways have been shown to cause neglect-like behaviour in rats, 10 while in humans treatment with dopamine agonists reduces the extent of unilateral neglect 11 (but see Grujic et al 12 ). Biases of spatial attention may be induced in healthy subjects through catecholamine agents, such as clonidine, which attenuate task-related brain activity in the posterior parietal cortex during spatial orienting.…”
Section: Introductionmentioning
confidence: 99%
“…F, Female; M, male; ns, not significant; contra, contralesional; ipsi, ipsilesional. nificantly improve neglect (Fleet et al, 1987). Similar results have been reported with apomorphine, a different dopamine agonist (Geminiani et al, 1998).…”
Section: Discussionsupporting
confidence: 84%
“…Dysfunction of the right hemisphere network results in more severe and long-lasting spatial inattention than equivalent left hemisphere dysfunction because of the dominance of the right hemisphere for the control of spatial attention: while right hemisphere networks allocate attention to both left and right hemispaces, left hemisphere networks do so only for the right hemispace (Mesulam, 1981). Consistent with animal studies that have reported neglect consequent upon lesions of the ascending dopaminergic pathways (Iversen, 1984), treatment with dopamine agonists reduces the extent of neglect in human subjects (Fleet et al, 1987).…”
Section: Introductionsupporting
confidence: 53%