Dopamine agonists and delusional jealousy in Parkinson's disease: A cross‐sectional prevalence study

Abstract

These findings suggest that dopamine agonist treatment represents a risk factor for DJ in PD independent of the presence of a dementing disorder, and the presence of this additional nonmotor side effect should be investigated in this clinical population.

Clinical Features of Delusional Jealousy in Elderly Patients With Dementia

“…1,2 Delusional jealousy may be observed in many psychiatric disorders, but previous clinical reports have noted the association of this morbid condition in several organic psychoses, including stroke, 3,4 Parkinson's disease, 5,6 traumatic brain injury, 7 and dementia. 8 Soyka et al 9 found that the prevalence of delusional jealousy was highest in organic psychoses (7.0%), followed by paranoid disorders (6.7%), alcohol psychosis (5.6%), and schizophrenia (2.5%); whereas in affective disorder, delusional jealousy was found in only 0.1% of patients.…”

Concomitant development of hypersexuality and delusional jealousy in patients with Parkinson's disease: A case series

“…DJ has been reported in medicated PD patients [2,10,11] but in contrast to HS, no studies directly investigated the neural bases of DJ in PD patients. However, fMRI studies in healthy subjects highlighted the role of dopaminergic fronto-striatal networks in motivating individuals to pair-bonding [4]; in particular, the insula and the dopaminergic circuits linking basal ganglia and the ventromedial prefrontal cortex (vmPFC) would mainly be involved in the evaluation of the rewarding nature of the social bonds and in the representation of associated emotions and somatic sensations, generally providing an affective meaning to the relationship with the partner.…”

“…We prolonged our previous cross-sectional investigation of ICDs and DJ [1,2], screened with the Questionnaire for Impulsive Compulsive Disorders in Parkinson's disease [6] and the Parkinson's Psychosis Questionnaire [7], until the recruitment of 1063 consecutive PD patients attending the Movement Disorder Tertiary Clinic of the Hospital of Viareggio, Italy. We did not include newly diagnosed drug-naïve PD patients or patients with clinical signs and neuroimaging findings suggestive of either secondary parkinsonism or primary atypical parkinsonism, such as Lewy body dementia, multiple system atrophy, progressive supranuclear palsy, and corticobasal degeneration.…”

“…The development of both impulse control disorders (ICDs) and delusional jealousy (DJ) in patients with Parkinson's disease (PD) is considered a non-motor side-effect of dopamine agonists [1,2], inducing a non-physiological tonic dopaminergic stimulation of the ventral frontostriatal loop [3], involved in both reward and social bond evaluation [4]. ICDs are behavioral disorders in which a person fails to resist the drive to behave in ways potentially dangerous for him-/herself or for other people [5].…”

Parkinson’s Disease Psychosis – Prevalence Patterns Across the EU-5

“…In prior studies covering the EU-5 nations, reported rates of hallucinations and delusions among patients with PD ranged from 10-45% in France, [34][35][36] 13-29% in Germany, 37,38 11-32% in Italy, [39][40][41] 15-42% in Spain 42,43 and 13-55% in the UK. 17,[44][45][46] These broad reported ranges highlight the difficulty of carrying out cross-study comparisons.…”