Dopamine agonists and stress produce different patterns of Fos-like immunoreactivity in the lateral habenula

Wirtshafter, David; Asin, Karen E.; Pitzer, Mark R.

doi:10.1016/0006-8993(94)91517-2

Cited by 132 publications

(90 citation statements)

References 39 publications

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“…In fact, prolonged induction of c-Fos has been reported in unusual conditions [21,22]. Previous studies [1] observed that chronic stimulants of different types, e.g., exposure of rats to longer periods of immobilization and continuous administration of dopamine agonists or cocaine resulted in the labeling of greater numbers of c-Fos protein-like immunoreactive neurons in the lateral habenular nucleus. Furthermore, several lines of evidence suggest that the lateral habenular nucleus is the site of functional interactions between the different parts of the central nervous system [5][6][7]23].…”

Section: Discussionmentioning

confidence: 99%

“…Presently, it is strongly believed that the lateral habenular nucleus is involved in a variety of important biological functions and behaviors, e.g., stress processing [1], sleep disorder [2], pain [3] and reproductive behaviors [4]. These diverse biological functions of the lateral habenular nucleus were suggested to be due to its connections with the dopaminergic, serotoninergic and cholinergic systems [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

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Prolonged Expression of c-Fos Protein in the Lateral Habenular Nucleus of the Japanese Monkey <i>(Macaca fuscata)</i> after Eye Enucleation

Kazi¹,

Mori²,

Kuchiiwa³

et al. 2004

Neurosignals

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To elucidate the effect of traumatic stress on the lateral habenular nucleus, we investigated the time course of the expression of c-Fos protein in this nucleus of the Japanese monkey (Macaca fuscata) after enucleation of one eye using c-Fos protein immunocytochemistry. c-Fos protein-like immunoreactive neurons were significantly increased; the increase started 1 h after the enucleation and remained high for 3–9 h in the lateral habenular nucleus on both sides. These results suggest that the prolonged expression of c-Fos protein occurred in the lateral habenular nucleus after traumatic stress through multiple transsynaptic activations.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prolonged Expression of c-Fos Protein in the Lateral Habenular Nucleus of the Japanese Monkey <i>(Macaca fuscata)</i> after Eye Enucleation

Kazi¹,

Mori²,

Kuchiiwa³

et al. 2004

Neurosignals

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“…Neurons in a round, circumscribed area in the LHbM are activated by different forms of stress, like immobilization, placement in a novel environment, food deprivation, chronic intermittent hypoxia, and lithium injection (Chastrette et al, 1991;Wirtshafter et al, 1994;Sica et al, 2000;Timonefa and Richard, 2001). This round, circumscribed area closely resembles the appearance of the LHbMPc/LHbMC in shape, size, and position, suggesting a role of this subnucleus in mediating a stress response.…”

Section: Putative Functional Roles Of Individual Subnucleimentioning

confidence: 99%

“…It is implicated in a variety of biological functions. Its involvement in stress responses (Chastrette et al, 1991;Wirtshafter et al, 1994;Sica et al, 2000;Amat et al, 2001), in maternal behavior (Corodimas et al, 1993;Wagner et al, 1998;Kalinichev et al, 2000), in male social behavior (De Vries et al, 1984;Insel et al, 1994), and in reward behavior (Brown et al, 1992;Hunt and McGregor, 1998) is well documented.…”

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confidence: 98%

Morphologic and cytochemical criteria for the identification and delineation of individual subnuclei within the lateral habenular complex of the rat

Geisler

Andres

Veh

2003

J of Comparative Neurology

117

142

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The lateral habenular complex is part of the habenular nuclei, a distinct structure in the dorsal diencephalon of all vertebrates. In contrast to the bewildering diversity of behaviors, in which the lateral habenular complex is thought to be involved, there is an astonishing lack of information concerning its cellular organization, its neuronal circuits, and the neurophysiological mechanisms, which may provide the physiological and molecular basis for its diverse biological functions. This problem may be due to an unexpected heterogeneity of the lateral habenular complex. Recently, a detailed subnuclear organization has been described (Andres et al. [1999] J Comp Neurol 407:130-150), which provides the base for a subsequent physiological and behavioral analysis of this area. Available criteria, however, can be applied to semithin sections only. To facilitate further investigations, the present work aimed to elaborate novel morphologic and immunocytochemical criteria that can be applied to conventional cryostat or Vibratome sections to allow identification and delineation of subnuclei of the lateral habenular complex. Consequently, the regional, cellular, and subcellular localization of approximately 30 different neuroactive molecules was investigated. Of these candidate molecules, gamma-aminobutyric acid-B receptor protein, Kir3.2 potassium channel protein, tyrosine hydroxylase, and neurofilament heavy chain proved to be suitable markers. Our observation suggests that the habenular subnuclei express distinct immunocytochemical characteristics. These features may be used to identify and delineate the subnuclei on conventional cryostat or Vibratome sections. From our results, it is expected that the further functional analysis of the lateral habenular complex will be facilitated considerably.

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“…Together, these results suggest that the habenula may play a more active and central role in the long-term modification of monoamine transmission and behavioral responses subsequent to aversive and stressful events. Electrophysiological and c-fos immunoreactivity studies in rodents have indeed demonstrated that the habenula is activated in response to various aversive stressors, including stimulation of the tail, restraint, novel environments, and footshock (Benabid and Jeaugey, 1989;Wirtshafter et al, 1994;Gao et al, 1996;Smith et al, 1997). We have previously reported that the habenula also showed increased expression of synaptic plasticity genes associated with long-term changes in neuronal activity in response to stress associated with fear conditioning (Ressler et al, 2002).…”

Section: Introductionmentioning

confidence: 96%

Lesions of the habenula produce stress- and dopamine-dependent alterations in prepulse inhibition and locomotion

Heldt

Ressler

2006

Brain Research

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The habenula complex modulates the a ctivity of dopamine and serotonin systems in the brain. An important question remains whether there is a link between habenula dysfunction and monoaminerelated disorders, such as schizophrenia. In this study, we describe an interaction between habenula lesions and stress that produces long-lasting effects on behavior. Mice received control lesions or bilateral electrolytic lesions of the habenula and were tested for fear-potentiated startle and freezing measures of conditioned fear. They w ere also tested for prepulse inhibition (PPI) and locomotor activity in the presence or absence of a dopaminergic agonist (apomorphine) or an atypical antipsychotic with mixed dopamine/serotonin antagonist properties (clozapine). There were no detectable effects of habenula lesions on fear conditioning and no effects on PPI in the absence o f stress. However, following conditioned fear stress, habenula-lesioned animals showed decreased PPI which normalized with clozapine. Lesioned animals also showed diminished activity at baseline, with hyperlocomotion following apomorphine. These data support the hypothesis that the habenula may be normally involved in stress-dependent regulation of monoamine systems.

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Dopamine agonists and stress produce different patterns of Fos-like immunoreactivity in the lateral habenula

Cited by 132 publications

References 39 publications

Prolonged Expression of c-Fos Protein in the Lateral Habenular Nucleus of the Japanese Monkey <i>(Macaca fuscata)</i> after Eye Enucleation

Prolonged Expression of c-Fos Protein in the Lateral Habenular Nucleus of the Japanese Monkey <i>(Macaca fuscata)</i> after Eye Enucleation

Morphologic and cytochemical criteria for the identification and delineation of individual subnuclei within the lateral habenular complex of the rat

Lesions of the habenula produce stress- and dopamine-dependent alterations in prepulse inhibition and locomotion

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