Dopamine and frontostriatal networks in cognitive aging

Klostermann, Ellen C.; Braskie, Meredith N.; Landau, Susan; O’Neil, James P.; Jagust, William J.

doi:10.1016/j.neurobiolaging.2011.03.002

Cited by 78 publications

(68 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is therefore biologically plausible that age-related reductions in caudate D1 receptor densities contribute to age-related reductions in functional connectivity of the prefrontal cortex to the right parietal cortex during WM. Further support for this notion comes from a recent study that found a relation between DA and age-related connectivity reductions of right inferior frontal gyrus to caudate during WM (Klostermann et al, 2011). Klostermann et al constrained their fMRI analysis to the caudate, whereas in the present study, we used GRF cluster-size correction, which likely prevented us from detecting connectivity differences of smaller extent such as those with the striatum.…”

Section: Decreased Frontoparietal Connectivity In Aging and Links To mentioning

confidence: 54%

Caudate Dopamine D1 Receptor Density Is Associated with Individual Differences in Frontoparietal Connectivity during Working Memory

Rieckmann¹,

Karlsson²,

Fischer³

et al. 2011

J. Neurosci.

View full text Add to dashboard Cite

We assess the relationship of age-related losses in striatal D1 receptor densities to age-related reductions in functional connectivity between spatially distinct cortical regions in healthy human participants. Previous neuroimaging studies have reported age-related differences in functional connectivity of the frontoparietal working memory network and the default mode network during task performance. We used functional magnetic resonance imaging and seed-based connectivity (right dorsolateral and medial prefrontal cortex) to extend these findings: Anterior-posterior connectivity of both these functional networks was reduced in older (65-75 years, n ϭ 18) compared with younger (20 -30 years, n ϭ 19) adults, whereas bilateral connectivity in prefrontal cortex was increased in older adults. Positron emission tomography with the D1 receptor ligand [ 11 C]SCH23390 was used to assess caudate D1 receptor density in the same sample. Older adults showed significantly reduced caudate D1 receptor density compared to the younger adults. Of key interest, partial correlations showed that individual differences in caudate D1 receptor density were positively associated with individual differences in dorsolateral prefrontal connectivity to right parietal cortex (BA40) and negatively with medial prefrontal connectivity to right parietal cortex (BA40 and postcentral gyrus), after controlling for age. We found no correlation of caudate D1 receptor density with anteriorposterior coupling within the default mode network or with bilateral frontal connectivity. These results are consistent with animal work that has identified a role for caudate D1 receptors in mediating information transfer between prefrontal areas and parietal cortex.

show abstract

Section: Decreased Frontoparietal Connectivity In Aging and Links To mentioning

confidence: 54%

Caudate Dopamine D1 Receptor Density Is Associated with Individual Differences in Frontoparietal Connectivity during Working Memory

Rieckmann¹,

Karlsson²,

Fischer³

et al. 2011

J. Neurosci.

View full text Add to dashboard Cite

show abstract

“…They also found a strongly connected network involving the rhinal cortex (BA 28,34,35,36) in elderly individuals. In contrast, Klostermann et al (2012) found that functional connectivity in the right caudate correlated with working memory demands, especially for young subjects. We, on the other hand, found a high hubness of the caudate rather for seniors.…”

Section: Age-related Differences In Memory Networkmentioning

confidence: 71%

Effects of Age on the Structure of Functional Connectivity Networks During Episodic and Working Memory Demand

et al. 2012

View full text Add to dashboard Cite

The aim of the study was to investigate age-related differences in large-scale functional connectivity networks during episodic and working memory challenge. A graph theoretical approach was used providing an exhaustive set of topological measures to quantify age-related differences in the network structure on various scales. In a single session, 10 young (22-30 years) and 10 senior (62-77 years) subjects performed an episodic and a working memory task during functional magnetic resonance imaging. Networks of functional connectivity were constructed by correlating the blood oxygenation level-dependent (BOLD) signal for every pair of voxels. Statistical network parameters yield a global characterization of the network topology, the quantification of the importance of specific regions, and shifts in local connectivity. An age-related increase in the density and size of the networks and loss of small-worldness was observed, related to an expanded distribution of brain activity during both memory demands in seniors, and a more specific and localized activity in young subjects. In addition, we found highly symmetrical neural networks in young subjects accompanied by a strong coupling between parietal and occipital regions. In contrast, seniors showed pronounced left-hemispheric asymmetry with decreased connectivity within occipital areas, but increased connectivity within parietal areas. Moreover, seniors engaged an additional frontal network strongly connected to parietal areas. In contrast to young subjects, seniors showed an almost identical structure of network connectivity during both memory tasks. The chosen network approach is explorative and hypothesis-free. Our results extend seed-based and BOLD-signal intensity focused studies, and support present hypotheses like compensation and dedifferentiation.

show abstract

“…In working memory tasks, older adults who retrieved their memory faster showed greater activity in the dorsal lateral prefrontal cortex (DLPFC) than those who did slower, while the same comparisons in younger adults showed the opposite pattern (Rypma and D'Esposito, 2000). These studies support the premise that aging alters the activation patterns of local brain regions, and that these regions interact to function globally as a network (Klostermann et al, 2012).…”

mentioning

confidence: 66%

Enhanced Motor Learning in Older Adults Is Accompanied by Increased Bilateral Frontal and Fronto-Parietal Connectivity

Lin

Chiang

et al. 2012

Brain Connectivity

View full text Add to dashboard Cite

We recently demonstrated that older adults can benefit as much as younger adults from learning skills in an interleaved manner. Here we investigate whether optimized learning through interleaved practice (IP) is associated with changes in inter-regional brain connectivity and whether younger and older adults differ in such brainbehavior correlations. Younger and older adults practiced a set of three 4-element motor sequences in a repetitive or in an interleaved order for 2 consecutive days. Retention of the practiced sequences was evaluated 3 days after practice with functional images acquired simultaneously. A within-subject design was used so that subjects practiced sequences in the other condition (repetitive or interleaved) 2-4 weeks later. Using the psychophysiological interaction (PPI) analysis approach, we found that IP led to higher functional connectivity between the right and left dorsal lateral prefrontal cortex (DLPFC) and between the dorsal premotor cortex (PMd) and inferior parietal lobule (IPL) in older adults. Moreover, increased connectivity between these regions was significantly associated with the learning benefits of IP. In contrast, in younger adults, enhanced learning as a result of IP was associated with increased connectivity between DLPFC and the supplementary motor area (SMA) and the inferior frontal gyrus. These data suggest that though younger and older gain similar behavioral benefits from interleaved training, aging may alter the operation of brain networks underlying such optimized learning.

show abstract

Dopamine and frontostriatal networks in cognitive aging

Cited by 78 publications

References 54 publications

Caudate Dopamine D1 Receptor Density Is Associated with Individual Differences in Frontoparietal Connectivity during Working Memory

Caudate Dopamine D1 Receptor Density Is Associated with Individual Differences in Frontoparietal Connectivity during Working Memory

Effects of Age on the Structure of Functional Connectivity Networks During Episodic and Working Memory Demand

Enhanced Motor Learning in Older Adults Is Accompanied by Increased Bilateral Frontal and Fronto-Parietal Connectivity

Contact Info

Product

Resources

About