Dopamine and Male Sexual Function

Giuliano, François; Allard, Julien

doi:10.1159/000049844

Cited by 99 publications

(59 citation statements)

References 51 publications

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“…Dopamine agonists-Dopamine agonists have been reported to improve sexual function [159] on the basis of research showing that sexual motivation is modulated by a number of central nervous system neurotransmitter and receptor changes induced, in part, by the action of sex steroids and by the central neurotransmitter dopamine. Dopamine neurotransmitter systems may play a critical intermediary role in the central regulation of sexual arousal and excitation, mood, and incentive-related sexual behavior, particularly in the motivational responses to conditioned external stimuli [160][161][162][163][164]. Although their use is controversial, more research is needed with dopamine agonists for men with androgen insufficiency and ED.…”

Section: 44mentioning

confidence: 99%

Testosterone and Erectile Function: From Basic Research to a New Clinical Paradigm for Managing Men with Androgen Insufficiency and Erectile Dysfunction

2007

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Objectives-Androgens are essential for the development and growth of the penis, and they regulate erectile physiology by multiple mechanisms. Our goal is to provide a concise overview of the basic research and how this knowledge can be translated into a new clinical paradigm for patient management. In addition, this new paradigm may serve as a basis for stimulating constructive debate regarding the use of testosterone in men, and to promote new, innovative basic and clinical research to further understand the underlying mechanisms of androgen action in restoring erectile physiology. Methods-A literature review was performed utilizing the US National Library of Medicine's PubMed database.Results-On the basis of evidence derived from laboratory animal studies and clinical data, we postulate that androgen insufficiency disrupts cellular-signaling pathways and produces pathologic alterations in penile tissues, leading to erectile dysfunction. In this review, we discuss androgendependent cellular, molecular, and physiologic mechanisms modulating erectile function in the animal model, and the implication of this knowledge in testosterone use in the clinical setting to treat erectile dysfunction. The new clinical paradigm incorporates many of the consensed points of view discussed in traditional consensed algorithms exclusively designed for men with androgen insufficiency. There are, however, novel and innovative differences with this new clinical paradigm. This paradigm represents a fresh effort to provide mandatory and optional management strategies for men with both androgen insufficiency and erectile dysfunction. Conclusions-The new clinical paradigm is evidence-based and represents one of the first attempts to address a logical management plan for men with concomitant hormonal and sexual health concerns.

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Section: 44mentioning

confidence: 99%

Testosterone and Erectile Function: From Basic Research to a New Clinical Paradigm for Managing Men with Androgen Insufficiency and Erectile Dysfunction

2007

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“…8,9 SD has also been attributed to other physical, clinical factors and psychological factors. 5,[10][11][12][13][14][15][16][17][18][19] Research on erectile dysfunction patients indicate that SD has significant adverse effects on both physical and mental health dimensions of quality of life (QOL). [20][21][22][23][24] Sexual dysfunction data for Asian populations are scant and primarily clinic-based.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of male and female sexual problems, perceptions related to sex and association with quality of life in a Chinese population: a population-based study

2005

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The prevalence of sexual problems (SP) and sexual satisfaction and their associations with sexrelated perceptions and quality of life (QOL) were investigated by interviewing 3257 and 1568 Chinese adults in Hong Kong by a specially designed computerized telephone-interviewing method. SP was prevalent among male (50.9%) and female (54%) respondents; approximately 50% were dissatisfied with their sexual life. Of respondents, 23.9% of men and 5.9% of women perceived sex as important and 52.5% for men and 33.8% of women reported adequate sexual knowledge. The prevalence of SP ranged from 3.4% (pain) to 29.7% (premature orgasm) for men and 6.9% (anxiety) to 24.7% (lack of interest) for women. Prevalence of erectile and lubrication problems were 9.6 and 23.6%, respectively. Sex-related knowledge, perceived importance of sex, perceived physical health status, sexual satisfaction were predictors of SP. Gender differences and strong cultural influences appear to exist. Moreover, SP and sexual satisfaction were associated with mental health and vitality QOL and overall life satisfaction. IntroductionRecent studies have showed that sexual dysfunctions are common in both sexes. [1][2][3][4] A study in the US estimated the prevalence of sexual dysfunction (SD) to be 43% among women and 31% among men. 5 An analysis of 22 general population surveys conducted in western countries summarized estimates of SD prevalence for men (inability to achieve orgasm: 5%, premature ejaculation: 35%, inhibited sexual excitement: 10-20% and inhibited sexual desire: 1-15%) and for women (inability to achieve orgasm: 5-30% and inhibited sexual desire: 1-35%). 6 Similarly, a large-scale international collaboration of multidisciplinary experts reported that 40-45% of adult women and 20-30% of adult men suffer from at least one SD. 7 It also reported the following prevalence rates among women: low levels of sexual interest at 17-55%, lubrication difficulties about 8-15%, orgasmic dysfunction at 25% and vaginismus at approximately 6%. The prevalence of erectile dysfunction was reported to be 1-9% among young males under 40 y old and rapidly increased with age to 20-40% among males between the ages of 60-69 y. 7 Age, lower education, socioeconomic status, perceived health, diabetes, heart disease and hypertension were found to be important determinants of erectile dysfunction in men. 8,9 SD has also been attributed to other physical, clinical factors and psychological factors. 5,[10][11][12][13][14][15][16][17][18][19] Research on erectile dysfunction patients indicate that SD has significant adverse effects on both physical and mental health dimensions of quality of life (QOL). [20][21][22][23][24] Sexual dysfunction data for Asian populations are scant and primarily clinic-based. [25][26][27][28][29][30] Moreover, little is known about the prevailing attitudes and perceptions of sexual problems (SP) or its effects on QOL in Asian populations. Few large-scale, population-based studies on SP have been reported in Chinese population study. The study i...

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“…Adding to the complexity are the findings that the effects on dopamine D 1 vs D 2 receptors may change depending on the dose of apomorphine (Castagna et al, 1997;Hull et al, 2004;Moses et al, 1995). The complex role of dopamine in male sexual behavior has been discussed extensively in several recent reviews Giuliano and Allard, 2001;Hull et al, 2004;Melis and Argiolas, 1995;Paredes and Agmo, 2004).…”

Section: Discussionmentioning

confidence: 99%

“…Dopamine is one of the main neurotransmitters involved in the central control of erectile functions, genital reflexes and male sexual behavior (Andersen et al, 2003;Argiolas and Melis, 2005;Giuliano and Rampin, 2000a,b;Giuliano and Allard, 2001;Heaton, 2000;Hull et al, 1986;Martino et al, 2005;Melis and Argiolas, 1995;Melis et al, 2006;Moses et al, 1995;Paredes and Agmo, 2004;Pehek et al, 1989;Succu et al, 2007). Apparently, the paraventricular hypothalamic nucleus, especially its oxytocinergic neurons, play an eminent role in the control of erectile function Melis, 2004, 2005;Martino et al, 2005;Succu et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Effects of acute and chronic apomorphine on sex behavior and copulation-induced neural activation in the male rat

Olivier

Jong

Dederen

et al. 2007

European Journal of Pharmacology

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Apomorphine is a non-selective dopaminergic receptor agonist. Because of its pro-erectile effects, apomorphine is clinically used for treatment of erectile dysfunction. We investigated the effects of subcutaneous apomorphine administration (0.4 mg/kg rat) on sexual behavior and matinginduced Fos-expression following acute (day 1) or chronic apomorphine treatment (days 8 and 15) in sexually experienced male rats. Consistent facilitatory effects of apomorphine were observed in the reduced numbers of mounts and intromissions over time and an increased ejaculation frequency on day 1. The first post-ejaculatory interval, however, was lengthened, while other behavioral parameters were unaffected. Fosimmunoreactivity induced by acute apomorphine administration (barrel cortex, paraventricular hypothalamic nucleus, central amygdala and locus coeruleus) was strongly reduced after chronic administration. After mating, induction of Fos-immunoreactivity was observed in well-known areas like medial preoptic nucleus and the posterodorsal medial amygdaloid area. Apomorphine, however, reduced mating-induced Fosimmunoreactivity in the nucleus accumbens shell and prevented its occurrence in its core area. This remarkable apomorphine effect was not observed in any other brain area. We conclude that the behavioral (pro-erectile) effects of apomorphine are consistent over time, and that the diminished accumbens-Fos-immunoreactivity and the elongated post-ejaculatory interval may reflect a decreased response to remote cues from the estrus female.

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Dopamine and Male Sexual Function

Cited by 99 publications

References 51 publications

Testosterone and Erectile Function: From Basic Research to a New Clinical Paradigm for Managing Men with Androgen Insufficiency and Erectile Dysfunction

Testosterone and Erectile Function: From Basic Research to a New Clinical Paradigm for Managing Men with Androgen Insufficiency and Erectile Dysfunction

Prevalence of male and female sexual problems, perceptions related to sex and association with quality of life in a Chinese population: a population-based study

Effects of acute and chronic apomorphine on sex behavior and copulation-induced neural activation in the male rat

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