1986
DOI: 10.1016/0306-4522(86)90011-4
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Dopamine and opiate receptors: Localization in the striatum and evidence for their axoplasmic transport in the nigrostriatal and striatonigral pathways

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Cited by 50 publications
(18 citation statements)
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“…The presence of D2 mRNA in neurons of the striatum demonstrates that the D2 receptor gene is expressed there by cells whose activity is regulated by the mesencephalic dopamine neurons. This result demonstrates the production of postsynaptic D2 receptors in striatal neurons (13). Nevertheless, since mRNA is present in cell bodies and possibly in dendrites but not in axons or terminals, presynaptic D2 receptors located on afferent terminals (including the dopamine ones) are most probably produced in the corresponding cell bodies outside the striatum, as suggested by others (13).…”
Section: Discussionmentioning
confidence: 56%
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“…The presence of D2 mRNA in neurons of the striatum demonstrates that the D2 receptor gene is expressed there by cells whose activity is regulated by the mesencephalic dopamine neurons. This result demonstrates the production of postsynaptic D2 receptors in striatal neurons (13). Nevertheless, since mRNA is present in cell bodies and possibly in dendrites but not in axons or terminals, presynaptic D2 receptors located on afferent terminals (including the dopamine ones) are most probably produced in the corresponding cell bodies outside the striatum, as suggested by others (13).…”
Section: Discussionmentioning
confidence: 56%
“…While the existence of dopamine receptors on striatal neurons and on dopamine terminals in the striatum is commonly accepted (9)(10)(11)(12)(13)(14)(15), there is no anatomical information about the characteristics of the cells expressing the dopamine receptor gene in the striatum. To better understand how D2 receptor gene expression contributes to nigrostriatal interactions, we have used in situ hybridization to study the characteristics of cells containing D2 receptor mRNA in adult rat forebrain, under normal conditions and after blockade of dopamine transmission with a dopamine receptor antagonist, haloperidol.…”
mentioning
confidence: 99%
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“…This neuropil reaction for D, receptor protein may result from anterograde transport of the receptor subtype from the CPu since pallidal afferents are derived largely from this region (Gerfen, 1992). Previous reports have described the anterograde transport of D, receptors from the sbiatum to the substantial nigra (Van der Kooy et al, 1986), and D, receptors from the substantia nigra to the striaturn (Wolf and Roth, 1990). Thus, it is reasonable to propose anterograde transport of the D, receptor.…”
Section: Discussionmentioning
confidence: 96%
“…(Stoof, 1983; Van der Kooy et al, 1986;Barone et al, 1987;Filloux et al, 1987). Furthermore, the det/eloprnent of D , receptors is distinct from that of both dopamine terminals and I>, receptors (Murrin and Zeng, 1986).…”
Section: Discusslonmentioning
confidence: 96%