Dopamine as A Possible Neurotransmitter in Gastric Relaxation

Motor complications in Parkinson disease: Clinical manifestations and management

“…PD itself also shows gastric motility and induces constipation [119][120][121]. Stimulation of dopamine receptors in the stomach may further depress gastric motility [122]. Lastly, excessive gastric acidity may delay gastric emptying.…”

Prokinetics in Gastroparesis

“…27 Mechanism of action Domperidone increases the amplitude of esophageal motor function and antroduodenal contractions, coordinates peristalsis across the pylorus, and accelerates gastric emptying. 28,29 The effect of domperidone on gastric emptying has been shown in short-term studies ( Table 2).…”

Dopamine Agonists/Antagonists in the Treatment of Gastrointestinal Diseases

“…For example, dopamine is known to relax the lower esophageal sphincter and has been suggested as a mediator of receptive relaxation of the stomach (Valenzuela, 1976). In contrast, contraction of GI muscle to dopamine has been reported from several locations in the GI tract in at least two species (Lanfranchi et al, 1978a;Anuras, 1981).…”