Dopamine D-1 but not D-2 receptor stimulation of the dorsal striatum potentiates apomorphine-induced jaw movements in rats

Koshikawa, Noriaki; Tomiyama, Katsunori; Omiya, Kiyomi; Beltrán, Keiko Kikuchi de; Kobayashi, Masafumi

doi:10.1016/0014-2999(90)90474-k

Cited by 41 publications

(14 citation statements)

References 15 publications

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“…In contrast, stim ulation of dopam ine D x and D 2 receptors is m ost effective after injections into the ventrolateral striatum , but ineffective after injections into the dorsal striatum 1 (Koshikawa et aL, 1989). Finally, the effects of YM-14673 could be blocked only partially by a dose of the dopamine D l/ D 2 receptor antagonist cis-(Z)-flupentixol that is highly effective in blocking the effects of dopam ine receptor agonists upon jaw movements (Koshikawa et aL, 1990b). These data together strongly suggest th at YM-14673 has additional effects, apart from those upon the dopam ine transmission.…”

Section: Discussionmentioning

confidence: 92%

“…injections were made in 0 .2 /i 1 solution (per side) of a m ixture of the respective two drugs. The doses of the antagonists have previously been found to block effec tively apomorphine-induced jaw movements (Koshikawa et al, 1990b;Kikuchi de Beltran et aL, 1994). Since YM-14673 produced responses th at could be attenuated by c/s-(Z)-flupentixol, it was decided to com pare the EM G pattern of YM-14673 with that of the combined administration of the dopam ine D x re ceptor agonist SKF 82958 (5 /xg) and the dopam ine D 2 receptor agonist quinpirole ( 1 0 ¿ig), a treatm ent known to elicit dopamine-specific, repetitive jaw movements (Koshikawa et al, 1991;Kikuchi de Beltran et al, 1992).…”

Section: Behavioural Observationsmentioning

confidence: 99%

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YM-14673, a thyrotropin-releasing hormone analogue, injected into the nucleus accumbens and the striatum produces repetitive jaw movements in rats

Miwa

Koshikawa

Miyata

et al. 1995

European Journal of Pharmacology

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Section: Discussionmentioning

confidence: 92%

Section: Behavioural Observationsmentioning

confidence: 99%

YM-14673, a thyrotropin-releasing hormone analogue, injected into the nucleus accumbens and the striatum produces repetitive jaw movements in rats

Miwa

Koshikawa

Miyata

et al. 1995

European Journal of Pharmacology

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“…saline (controls). The doses of dopamine agonists and antagonists were chosen in accordance with previous papers showing clear efficacy of these compounds, under similar experimental conditions, within the range of concentrations used in our study (Koshikawa et al. , 1990; Tomiyama et al.…”

Section: Methodsmentioning

confidence: 99%

“…There were nine treatment groups: (Koshikawa et al, 1990;Tomiyama et al, 1995;Mao et al, 1996;Steinberg et al, 1998).…”

Section: Methodsmentioning

confidence: 99%

Selective stimulation of striatal dopamine receptors of the D₁‐ or D₂‐class causes opposite changes of fos expression in the rat cerebral cortex

Blandini

Fancellu

Orzi

et al. 2003

Eur J of Neuroscience

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It has been suggested that activation of striatal neurons expressing D1 or D2 dopamine receptors elicits opposite changes in the net output of the basal ganglia circuitry and, consequently, in the functional interactions of the circuit with the cerebral cortex. In particular, it has been recently reported that striatal D1 receptors may regulate cortex function. To further address this issue, we mapped cerebral expression of Fos protein following intrastriatal stimulation of D1- or D2-class receptors in freely moving animals. Using permanent cannulas implanted in the right striatum, Sprague-Dawley rats received intrastriatal microinfusions of SKF 38393 (D1 agonist) or quinpirole (D2 agonist) or saline (controls), combined with systemic administration of D1 antagonist SCH 23390 or D2 antagonist eticlopride or saline. Animals treated with SKF 38393 showed dose-dependent, massive Fos increases in the motor, somatosensory, auditory, visual and limbic regions of the cerebral cortex, ipsilaterally to the injected striatum. Consistent Fos expression was also found in the injected striatum and, bilaterally, in the nucleus accumbens shell. These increases were effectively counteracted by systemic SCH 23390. Conversely, quinpirole did not induce significant cortical or striatal expression of Fos, which was instead observed after the systemic administration of eticlopride. Fos was not detected in any of the other basal ganglia nuclei, regardless of the dopamine agonists or antagonists used. Our results confirm that striatal D1 dopamine receptors play a central role in the modulation of cortical activity, thus providing additional information on the functional interaction between basal ganglia circuitry and cerebral cortex.

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“…In addition to being regulated by intrinsic GABAergic inputs, the activity of the nucleus accumbens output neurons is also controlled by glutamatergic inputs arising from the prefrontal cortex, hippocampus and amygdala, and by dopaminergic input from the ventral tegmental area (Groenewegen et al, 1996;Kelley, 1999). Evidence has been presented that injections of dopamine agonists into the nucleus accumbens are capable of inducing oral activity as well (Koene et al, 1993;Koshikawa et al, 1990). The regulation of chewing movements is not clearly understood because it may be associated Table 3.…”

Section: Discussionmentioning

confidence: 99%

Roles of .Mu.-Opioid Receptors in Development of Tolerance to Diisopropylfluorophosphate (Dfp)

Tien

Fan

et al. 2005

J. Toxicol. Sci.

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-Anatomical evidence indicates that cholinergic and opioidergic systems are co-localized and acting on the same neuron. However, the regulatory mechanisms between cholinergic and opioidergic system have not been well characterized. In the present study, the potential involvement of µ-opioid receptors in mediating the changes of toxic signs and muscarinic receptor binding after administration of irreversible anti-acetylcholinesterase diisopropylfluorophosphate (DFP) was investigated. DFP (1 mg/kg/day, subcutaneous injection, s.c.)-induced tremors and chewing movements were monitored during the 28-day treatment period in µ-opioid receptor knockout and wild type mice. Autoradiographic studies of total, M1, and M2 muscarinic receptors were conducted using [ ]-AF-DX384 as ligands, respectively. DFP-induced tremors in both µ-opioid receptor knockout and wild type mice showed tolerance development. However, DFP-induced tremors in µ-opioid receptor knockout mice showed delayed tolerance development than that of DFP-treated wild type controls. DFPinduced chewing movements in both µ-opioid receptor knockout and wild type mice failed to show development of tolerance after four weeks of treatment. M2 muscarinic receptor binding of DFP-treated µ-opioid receptor knockout mice was significantly decreased than that of the DFP-treated wild type controls in the striatum, but not in the cortex and hippocampus. However, there were no significant differences in total and M1 muscarinic receptor binding between DFP-treated µ-opioid receptor knockout and wild type mice in the cortex, striatum and hippocampus. These studies indicate that µ-opioid receptors play an important role through the striatal M2 muscarinic receptors to regulate the development of tolerance to DFP-induced tremors.

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Dopamine D-1 but not D-2 receptor stimulation of the dorsal striatum potentiates apomorphine-induced jaw movements in rats

Cited by 41 publications

References 15 publications

YM-14673, a thyrotropin-releasing hormone analogue, injected into the nucleus accumbens and the striatum produces repetitive jaw movements in rats

YM-14673, a thyrotropin-releasing hormone analogue, injected into the nucleus accumbens and the striatum produces repetitive jaw movements in rats

Selective stimulation of striatal dopamine receptors of the D₁‐ or D₂‐class causes opposite changes of fos expression in the rat cerebral cortex

Roles of .Mu.-Opioid Receptors in Development of Tolerance to Diisopropylfluorophosphate (Dfp)

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Dopamine D-1 but not D-2 receptor stimulation of the dorsal striatum potentiates apomorphine-induced jaw movements in rats

Cited by 41 publications

References 15 publications

YM-14673, a thyrotropin-releasing hormone analogue, injected into the nucleus accumbens and the striatum produces repetitive jaw movements in rats

YM-14673, a thyrotropin-releasing hormone analogue, injected into the nucleus accumbens and the striatum produces repetitive jaw movements in rats

Selective stimulation of striatal dopamine receptors of the D1‐ or D2‐class causes opposite changes of fos expression in the rat cerebral cortex

Roles of .Mu.-Opioid Receptors in Development of Tolerance to Diisopropylfluorophosphate (Dfp)

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Selective stimulation of striatal dopamine receptors of the D₁‐ or D₂‐class causes opposite changes of fos expression in the rat cerebral cortex