2005
DOI: 10.1016/j.pbb.2005.03.012
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Dopamine D, but not D receptor agonists are emetogenic in ferrets

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Cited by 46 publications
(55 citation statements)
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“…4 Interestingly, ABT-724 was found able to induce not only penile erection when given systemically and centrally in rats with a potency similar to that of apomorphine, a classical mixed dopamine receptor agonist that facilitates male sexual behaviour in laboratory animals (see ), but was also found unable to induce vomiting in the ferret, an animal model of nausea and vomiting like PD-168,077 and CP 226269, at variance from classical mixed D1/D2 and D2-selective agonists [Brioni et al, 2004;Osinski et al, 2005;Brioni and Moreland, 2006]. PD-168,077 was found able to induce penile erection also when injected into the PVN ], e.g., one of the sites where dopamine acts to induce penile erection by activating oxytocinergic neurotransmission (see [Melis et al, 1987;Argiolas and Melis 1995;Baskerville et al, 2008Baskerville et al, , 2009Melis and Argiolas, 2011]) and to induce c-FOS expression and extracellular regulated kinase (ERK) phosphorylation in this hypothalamic nucleus [Bitner et al, 2006;Baskerville et al, 2008Baskerville et al, , 2009].…”
Section: Accepted Manuscriptmentioning
confidence: 99%
See 1 more Smart Citation
“…4 Interestingly, ABT-724 was found able to induce not only penile erection when given systemically and centrally in rats with a potency similar to that of apomorphine, a classical mixed dopamine receptor agonist that facilitates male sexual behaviour in laboratory animals (see ), but was also found unable to induce vomiting in the ferret, an animal model of nausea and vomiting like PD-168,077 and CP 226269, at variance from classical mixed D1/D2 and D2-selective agonists [Brioni et al, 2004;Osinski et al, 2005;Brioni and Moreland, 2006]. PD-168,077 was found able to induce penile erection also when injected into the PVN ], e.g., one of the sites where dopamine acts to induce penile erection by activating oxytocinergic neurotransmission (see [Melis et al, 1987;Argiolas and Melis 1995;Baskerville et al, 2008Baskerville et al, , 2009Melis and Argiolas, 2011]) and to induce c-FOS expression and extracellular regulated kinase (ERK) phosphorylation in this hypothalamic nucleus [Bitner et al, 2006;Baskerville et al, 2008Baskerville et al, , 2009].…”
Section: Accepted Manuscriptmentioning
confidence: 99%
“…18 been found unable to induce vomiting in the ferret, a classic emesis model for identifying drugs that induce nausea and vomiting [Brioni et al, 2004, Osinski et al, 2005Brioni and Moreland, 2006].…”
Section: Accepted Manuscriptmentioning
confidence: 99%
“…14,15 Coexpression of D 2L receptor with chimeric GR qo5 in HEK-293 cells allowed determination of functional selectivity against D 2L receptor and in identifying both agonists and antagonists. 39 None of the tested compounds showed D 2 agonist (EC 50 >10 µM) or antagonist (IC 50 >10 µM) activities in this assay.…”
Section: Resultsmentioning
confidence: 99%
“…This is supported by dose-dependent blockade of emetic events by competitive D2 antagonist such as haloperidol and droperidol. 56 As these agents are pure dopamine antagonists, central nervous system toxicity limits front-line application of this class of drugs. Though effective, extrapyramidal side effects frequently lead to treatment discontinuation.…”
Section: Butyrophenonesmentioning
confidence: 99%