“…4 Interestingly, ABT-724 was found able to induce not only penile erection when given systemically and centrally in rats with a potency similar to that of apomorphine, a classical mixed dopamine receptor agonist that facilitates male sexual behaviour in laboratory animals (see ), but was also found unable to induce vomiting in the ferret, an animal model of nausea and vomiting like PD-168,077 and CP 226269, at variance from classical mixed D1/D2 and D2-selective agonists [Brioni et al, 2004;Osinski et al, 2005;Brioni and Moreland, 2006]. PD-168,077 was found able to induce penile erection also when injected into the PVN ], e.g., one of the sites where dopamine acts to induce penile erection by activating oxytocinergic neurotransmission (see [Melis et al, 1987;Argiolas and Melis 1995;Baskerville et al, 2008Baskerville et al, , 2009Melis and Argiolas, 2011]) and to induce c-FOS expression and extracellular regulated kinase (ERK) phosphorylation in this hypothalamic nucleus [Bitner et al, 2006;Baskerville et al, 2008Baskerville et al, , 2009].…”