Dopamine D1-like receptors modulate synchronized oscillations in the hippocampal–prefrontal–amygdala circuit in contextual fear

Stubbendorff, Christine; Hale, Ed; Bast, Tobias; Cassaday, Helen J.; Martin, Stephen J.; Suwansawang, Sopapun; Halliday, David M.; Stevenson, Carl W.

doi:10.1038/s41598-023-44772-6

Cited by 2 publications

(1 citation statement)

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“…Plastic changes involve cortical representations and the refinement of contextual input as part of circuit modulation. Theta oscillatory activity across several brain regions has been found to be critical in this regard [31,[84][85][86][87], e.g., in relation to long-term fear memory, modulation of synchronized oscillations in the hippocampal-prefrontal-amygdala circuit in contextual fear, and changes in brain rhythms and connectivity tracking fear acquisition and reversal. Projection neurons of the lateral amygdala exhibit resonant/oscillatory behavior of their membrane potential and provide a cellular correlate of coherent theta activity in amygdalo-hippocampal pathways (see Figure 1).…”

Section: Fear Conditioning Functional Imaging and Theta Rhythmsmentioning

confidence: 99%

Cellular Processes and Synaptic Interactions in Nuclei of the Amygdala

Heinbockel

2024

Learning and Memory - From Molecules and Cells to Mind and Behavior

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The amygdala is a core structure of the limbic system in the brain. Anatomically, the amygdaloid complex comprises ~13 nuclei in the mid-temporal lobe. The amygdaloid complex is important for regulating emotional behavior, anxiety, fear, learning and memory. It is involved in several neurological disorders such as post-traumatic stress syndrome, depression, and temporal lobe epilepsy. The lateral nucleus of the amygdala is the main sensory input station of the amygdala and receives sensory information from cortical and subcortical (thalamic) fields. Thalamic afferents project to the lateral amygdala medially from the internal capsule, whereas cortical afferents arrive from the internal capsule. These two input pathways converge on populations of principal neurons and interneurons, both of which can be identified by characteristic electrophysiological, neurochemical, and morphological properties. Pressing issues for our understanding of the organization and operation of the amygdala are the functional significance of modulatory inputs from various signaling systems and the plasticity of its synaptic circuitry in relation to its pathway-specific inputs. This chapter reviews progress in this regard as far as cellular processes and synaptic interactions in nuclei of the amygdala are concerned which will help with our understanding of neural mechanisms underlying fear, anxiety, and related clinical disorders.

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Section: Fear Conditioning Functional Imaging and Theta Rhythmsmentioning

confidence: 99%

Cellular Processes and Synaptic Interactions in Nuclei of the Amygdala

Heinbockel

2024

Learning and Memory - From Molecules and Cells to Mind and Behavior

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Coping switches stress–evoked network disconnection to a new forebrain network state

Durieux,

Herbeaux,

Totah

et al. 2024

Preprint

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Coping with stress is critical to maintaining mental and physical health. Acute stress is associated with changes in neuronal activity across many brain regions and with the reorganization of cross– region correlations in neurovascular coupling. How neuronal activity itself is coordinated across regions during stress, and how neuronal networks are modified during coping, are unknown. We recorded in rats local field potentials (LFPs) simultaneously from five stress–responsive regions during stress and stress–coping behavior. We characterized network activity by computing cross– region coherence, Granger causality, and phase–amplitude coupling on bipolar derivatives of LFPs in the lateral habenula, basolateral amygdala, dorsal hippocampus, prelimbic cortex, and anterior cingulate cortex. First, we established a stress–coping model in rats. We showed that the behavioral response to acute 10–minute restraint stress returned to baseline after a second restraint 3 hours later. The pre–stress state was characterized by robust global network interactions in the theta (6– 9 Hz) and gamma (45–65 Hz) bands. Stress exposure led to nearly complete loss of connectivity. During coping, the robust connectivity reemerged, but in a new pattern compared to the pre–stress state. Finally, we found that baseline, stressed, and coping states can be predicted with high accuracy (> 90 %) from network activity. Overall, we showed that the acutely stressed brain state was primarily a state of network disconnection, while coping was a new network state rather than a return to baseline.

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Dopamine D1-like receptors modulate synchronized oscillations in the hippocampal–prefrontal–amygdala circuit in contextual fear

Cited by 2 publications

References 83 publications

Cellular Processes and Synaptic Interactions in Nuclei of the Amygdala

Cellular Processes and Synaptic Interactions in Nuclei of the Amygdala

Coping switches stress–evoked network disconnection to a new forebrain network state

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