Dopamine D2/D3 imbalance during migraine attack and allodynia in vivo

Abstract

Our findings demonstrate that there is an imbalanced uptake of [C]raclopride during the headache attack and ictal allodynia, which indicates reduction and fluctuation in ictal endogenous DA release in migraineurs. Moreover, the longer the history and recurrence of migraine attacks, the lower the ictal endogenous DA release.

Dopaminergic and serotonergic mechanisms in the modulation of pain: In vivo studies in human brain

“…Abnormal function of the dopaminergic system has varied with the type of the chronic pain condition. Pain conditions that are primarily of neural origin, such as chronic neuropathic orofacial pain (Hagelberg et al, 2003a, b), migraine in the ictal phase (DaSilva et al, 2017), central pain in Parkinson's disease (Niccolini et al, 2014), and pain in restless legs syndrome (Cervenka et al, 2006) have been associated with an increased baseline availability of striatal dopamine D 2 /D 3 receptors. In contrast, pain conditions that are primarily of musculoskeletal origin, such as fibromyalgia (Ledermann et al, 2016;Wood et al, 2007b) or chronic back pain (Martikainen et al, 2015) associated with a decreased baseline availability of striatal dopamine D 2 /D 3 receptors.…”

“…In contrast, pain conditions that are primarily of musculoskeletal origin, such as fibromyalgia (Ledermann et al, 2016;Wood et al, 2007b) or chronic back pain (Martikainen et al, 2015) associated with a decreased baseline availability of striatal dopamine D 2 /D 3 receptors. In chronic pain of primarily musculoskeletal origin, also the capacity to increase striatal dopamine release is decreased (Martikainen et al, 2015;Wood et al, 2007b), unlike in migraine (DaSilva et al, 2017). Presynaptic dopamine level has been reduced independent whether chronic pain is due to a neural or musculoskeletal disorder, although it has been only little studied (Table 2).…”

Reward Circuitry Plasticity in Pain Perception and Modulation

“…Regarding the evaluation of the dopaminergic system in painful syndromes, a significant increase in the BP ND of the D2/D3 dopamine receptors selective radioligand [11C] raclopride has been found within the striatum of migraine patients during both the spontaneous headache attack and during allodynia induced by a sustained thermal pain threshold challenge, when compared to the non-headache (interictal) period ( DaSilva et al, 2017 ). A decreased dopamine release (e.g., change in the [11C] raclopride BP ND from baseline to the activated state) and thus lower D2/D3 receptor activation has also been reported in the ventral striatum of chronic non-neuropathic back pain patients, when compared to controls, during a pain challenge ( Martikainen et al, 2015 ).…”

The prevalence of the palmo-mental reflex in patients with cervicocranialgia

“…В связи с этим представляются интересными данные A. de Silva и соавт. [42], полученные при ПЭТ: в отличие от здоровых в полосатом теле больных с мигренью наблюдаются значительное снижение уровня дофамина во время приступа, а также отклонения от нормального уровня дофамина в межприступный период, причем снижение уровня дофамина было прямо пропорционально длительности заболевания и частоте приступов [42]. Учитывая эти данные, можно предположить, что ЛПР у больных с мигренью связан с уменьшением модулирующего влияния базальных ганглиев, вызванным снижением содержания дофамина в полосатом теле во время приступа и отклонениями в его содержании в межприступный период.…”