Dopamine D2 Receptors in the Insular Cortex and the Personality Trait of Novelty Seeking

Suhara, Tetsuya; Yasuno, Fumihiko; Sudo, Yasuhiko; Yamamoto, Masahiro; Inoue, Makoto; Okubo, Yoshiro; Suzuki, Kazutoshi

doi:10.1006/nimg.2001.0761

Cited by 167 publications

(111 citation statements)

References 33 publications

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“…The insula does not only exhibit a relationship between dopaminergic tone and the personality trait of novelty seeking (Suhara et al, 2001) but has also been shown in rat studies to play a role in pain modulation, including descending networks (Burkey et al, 1999). In the rat, dopamine and GABA appear to be key neurotransmitters in the function of this cortical region, at least in the anterior part (Ohara et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

The Anatomy of the Mesolimbic Reward System: A Link between Personality and the Placebo Analgesic Response

Schweinhardt¹,

Seminowicz²,

Jaeger³

et al. 2009

J. Neurosci.

182

153

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The anticipation of clinical benefit, a crucial component of placebo analgesia, has been suggested to be a special case of reward anticipation. Since reward processing is closely linked to the ventral striatum and the neurotransmitter dopamine, we examined the relationships between brain gray matter, placebo analgesic response, and personality traits associated with dopaminergic neurotransmission. We report that dopamine-related traits predict a substantial portion of the pain relief an individual gains from a sham treatment. Voxelbased morphometry of magnetic resonance images shows that the magnitude of placebo analgesia is related to gray matter density (GMD) in several brain regions, including the ventral striatum, insula, and prefrontal cortex. Similarly, GMD in ventral striatum and prefrontal cortex is related to dopamine-related personality traits. Our findings highlight the relationship between placebo and reward and potentially offer ways of identifying subjects who are likely to show large placebo analgesic responses.

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Section: Discussionmentioning

confidence: 99%

The Anatomy of the Mesolimbic Reward System: A Link between Personality and the Placebo Analgesic Response

Schweinhardt¹,

Seminowicz²,

Jaeger³

et al. 2009

J. Neurosci.

182

153

View full text Add to dashboard Cite

show abstract

“…An exploratory, whole-brain PET study of dopamine D2 receptor binding (Suhara et al, 2001) found a correlation in anterior cingulate between D2 binding and the personality trait of novelty seeking (akin to both extraversion and BAS, Cloninger et al, 1993), r = -.45.…”

Section: Implications For Theories Of Acc Functionmentioning

confidence: 99%

Personality predicts working-memory-related activation in the caudal anterior cingulate cortex

Gray

Braver

2002

Cognitive, Affective, & Behavioral Neuroscience

155

112

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Behavioral studies suggest that two affective dimensions of personality are associated with working memory (WM) function. WM load is known to modulate neural activity in caudal anterior cingulate cortex (ACC), a brain region critical for the cognitive control of behavior. On this basis, we hypothesized that neural activity in caudal ACC during a WM task should be associated with personality: negatively with behavioral approach sensitivity (BAS), and positively with behavioral inhibition sensitivity (BIS). Using functional magnetic resonance imaging, we measured brain activity in 14 participants performing a 3-back WM task. Higher selfreported BAS predicted better WM performance (r=.27) and lower WMrelated activation in caudal ACC (r=-.84), suggesting personality differences in cognitive control. The results bolster approach-withdrawal (action control) theories of personality, and suggest refinements to the dominant views of ACC and personality.

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“…Many studies have found that the insular cortex regulates dopaminergic activity associated with the NS trait. For instance, a negative correlation between insular cortex DA receptor binding and the NS score has been demonstrated (Suhara et al, 2001). A later study also reported an inverse correlation between DA receptor availability in the insula and NS (Kaasinen et al, 2004).…”

Section: Accepted Manuscriptmentioning

confidence: 96%

The cortical surface area of the insula mediates the effect of DBH rs7040170 on novelty seeking

Cui

et al. 2015

NeuroImage

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The cortical surface area of the insula mediates the effect of DBH rs7040170 on novelty seeking, NeuroImage (2015), doi: 10.1016/j.neuroimage. 2015.05.033 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT2 AbstractNovelty seeking (NS) is a personality trait important for adaptive functioning, but an excessive level of NS has been linked to psychiatric disorders such as ADHD and substance abuse. Previous research has investigated separately the neural and genetic bases of the NS trait, but results were mixed and neural and genetic bases have yet to be examined within the same study. In this study, we examined the interrelationships among the dopamine beta-hydroxylase (DBH) gene, brain structure, and the NS trait in 359 healthy Han Chinese subjects. We focused on the DBH gene because it encodes a key enzyme for dopamine metabolism, NS is believed to be related to the dopaminergic system and has been reported associated with DBH variation. Results showed a significant positive association between the cortical surface area of the left insula and NS score. Furthermore, the DBH genetic polymorphism at the SNP rs7040170 was strongly associated with both the surface area of the left insula and NS score, with G carriers having a larger left insula surface area and a higher NS score than AA homozygotes. Subsequent path analysis suggested that the insula partially mediated the association between the DBH gene and the NS trait. Our data provided the first evidence for the involvement of the insula in the dopamine-NS relationship.Future studies of molecular mechanisms underlying the NS personality trait and related psychiatric disorders should consider the mediation effect of the neural structure.

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Dopamine D2 Receptors in the Insular Cortex and the Personality Trait of Novelty Seeking

Cited by 167 publications

References 33 publications

The Anatomy of the Mesolimbic Reward System: A Link between Personality and the Placebo Analgesic Response

The Anatomy of the Mesolimbic Reward System: A Link between Personality and the Placebo Analgesic Response

Personality predicts working-memory-related activation in the caudal anterior cingulate cortex

The cortical surface area of the insula mediates the effect of DBH rs7040170 on novelty seeking

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