2021
DOI: 10.1101/2021.12.08.471871
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Dopamine D2Rs Coordinate Cue-Evoked Changes in Striatal Acetylcholine Levels

Abstract: In the striatum, acetylcholine (ACh) neuron activity is modulated co-incident with dopamine (DA) release in response to unpredicted rewards and reward predicting cues and both neuromodulators are thought to regulate each other. While this co-regulation has been studied using stimulation studies, the existence of this mutual regulation in vivo during natural behavior is still largely unexplored. One long-standing controversy has been whether striatal DA is responsible for the induction of the cholinergic pause … Show more

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