Dopamine D3 receptor agonists produce similar decreases in body temperature and locomotor activity in D3 knock-out and wild-type mice

Neurotensin Gene Expression and Behavioral Responses Following Administration of Psychostimulants and Antipsychotic Drugs in Dopamine D3 Receptor Deficient Mice

“…Contradictory results have been reported concerning the presence of a transient increase in spontaneous locomotor activity during the initial (5 or 15 min) exploration of a novel environment in D 3 receptor deficient mice (Accili et al 1996;Xu et al 1997;Boulay et al 1999). Our results indicate that basal activity levels in wild-type and mutant mice were similar during the light period of the light/dark cycle ( Figure 6A).…”

The Dopamine D3Receptor Is Part of a Homeostatic Pathway Regulating Ethanol Consumption

“…We draw this conclusion although the antagonists we used to block the D 3 R and D 2 R, respectively, have some receptor cross-reactivity. Although we cannot definitively conclude that the effect of U-99194A is solely via the D 3 R, the selectivity of U-99194A is reported to be higher for D 3 R compared with D 2 R (Franklin et al, 1998;Boulay et al, 1999;Gyertyan and Saghy, 2004). Likewise, the D 2 R antagonist eticlopride is reported to have higher selectivity for D 2 R than for D 3 R (Tang et al, 1994).…”

The role of central dopamine D3 receptors in drug addiction: a review of pharmacological evidence

“…Furthermore, 7-OH-DPAT and PD128907 doses below 10 µg/kg have been reported to produce inhibition of novelty-stimulated locomotion in wild type, but not in D 3 receptor knockout mice [227]. All other D 3 knockout studies using 7-OH-DPAT or PD128907 doses at least 10-fold higher reported that neither 7-OH-DPAT nor PD128907 inhibit locomotion through selective D 3 receptor stimulation [28,29], and hence concluded that locomotor inhibitory affects of 7-OH-DPAT are mediated through D 2 autoreceptors or other receptors.…”