2022
DOI: 10.1016/j.neuroscience.2022.03.019
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Dopamine Dysregulation and Altered Responses to Drugs Affecting Dopaminergic Transmission in a New Dopamine Transporter Knockout (DAT-KO) Rat Model

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Cited by 7 publications
(24 citation statements)
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“…These profiles closely matched the underlying anatomically and functionally defined regions of the striatum (Floresco, 2015; Hunnicutt et al, 2016; Voorn et al, 2004); dorsal and ventral domains rostrally corresponded to the dorsolateral striatum and nucleus accumbens, respectively, and the caudal domain to the tail striatum. Basal dopamine concentration in the dorsolateral striatum measured here is consistent with previous observations using the same technique (FSCAV; DiCarlo et al, 2019; Lloyd et al, 2022). Notably, these values are 10–40‐fold greater than those previously obtained using microdialysis (Gu et al, 2015; Shou et al, 2006), likely explained by the significant tissue damage associated with the microdialysis probe (Ø > 200 μm) leading to underestimation of dopamine concentration (Bungay et al, 2003; Yang et al, 1998).…”
Section: Discussionsupporting
confidence: 92%
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“…These profiles closely matched the underlying anatomically and functionally defined regions of the striatum (Floresco, 2015; Hunnicutt et al, 2016; Voorn et al, 2004); dorsal and ventral domains rostrally corresponded to the dorsolateral striatum and nucleus accumbens, respectively, and the caudal domain to the tail striatum. Basal dopamine concentration in the dorsolateral striatum measured here is consistent with previous observations using the same technique (FSCAV; DiCarlo et al, 2019; Lloyd et al, 2022). Notably, these values are 10–40‐fold greater than those previously obtained using microdialysis (Gu et al, 2015; Shou et al, 2006), likely explained by the significant tissue damage associated with the microdialysis probe (Ø > 200 μm) leading to underestimation of dopamine concentration (Bungay et al, 2003; Yang et al, 1998).…”
Section: Discussionsupporting
confidence: 92%
“…As described previously, stimulation of the MFB evoked dopamine release in the dorsolateral striatum consistent with other studies (Covey & Garris, 2009;Kuhr et al, 1987;Lloyd et al, 2022). We show here for the first time that such stimulation also evoked dopamine release in the tail striatum, indicating that both pathways project via the MFB.…”
Section: The Tail and Dorsolateral Striatum Are Distinct Dopamine Dom...supporting
confidence: 93%
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