Dopamine enhances locomotor activity for mating in male honeybees (Apis mellifera L.)

Akasaka, Shinya; Sasaki, Kohsuke; Harano, Ken-ichi; Nagao, Takashi

doi:10.1016/j.jinsphys.2010.03.013

Cited by 40 publications

(34 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…All three DA receptor genes ( Amdop1 , Amdop2 and Amdop3 ) were expressed at higher levels in 8‐day‐old males than in 4‐day‐old males. This developmental increase paralleled the observed elevation in brain DA and also corresponds to the emergence of DA‐mediated reproductive behaviours (Akasaka et al ., 2010). In 12‐day‐old males, Amdop1 and Amdop2 were down‐regulated compared to 8‐day‐old males, whereas Amdop3 expression was stable during this period.…”

Section: Discussionsupporting

confidence: 70%

Regulation of the brain dopaminergic system by juvenile hormone in honey bee males (Apis mellifera L.)

Sasaki

Akasaka

Mezawa

et al. 2012

Insect Molecular Biology

View full text Add to dashboard Cite

Dopamine (DA) and juvenile hormone (JH) are multifunctional regulators of behaviour in social insects, with distinct effects across species and even between different dominance positions within the same species. We examined the effects of JH on the brain dopaminergic system in honey bee males to investigate the potential relationship between JH and DA within Apis mellifera. Both DA content and the expression of three DA receptor genes (Amdop1, Amdop2 and Amdop3) increased in the male honey bee brain from day 4 to day 8 after emergence. Treatment of 4-day-old males with a JH analogue (methoprene, JHA) enhanced brain DA levels. Brain expression of Amdop1 was also enhanced by JHA but not by a DA receptor agonist 2-amino 6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene (6,7-ADTN), indicating that Amdop1 up-regulation was not mediated by increased DA receptor stimulation. Furthermore, Amdop1 expression was still enhanced when JHA was co-applied with the DA receptor antagonist cis-(Z)-flupenthixol. Expression levels of Amdop2 and Amdop3 were not altered by JHA, 6,7-ADTN or by JHA plus the DA receptor antagonist. Regulation of the brain dopaminergic system by JH, as observed in solitary species, is conserved in male honey bees but not in female honey bees and other advanced eusocial insects.

show abstract

Section: Discussionsupporting

confidence: 70%

Regulation of the brain dopaminergic system by juvenile hormone in honey bee males (Apis mellifera L.)

Sasaki

Akasaka

Mezawa

et al. 2012

Insect Molecular Biology

View full text Add to dashboard Cite

show abstract

“…Furthermore, the regulation of task performance involves mechanisms of neural organization that may vary with worker age (Muscedere et al 2011; Stieb et al 2012; Giraldo et al 2013) and be controlled by biogenic amines (Schulz and Robinson 2001; Seid and Traniello 2005; Jones et al 2009; Muscedere and Traniello 2012; Muscedere et al 2013, 2016; Kamhi and Traniello 2013; Smith et al 2013; Kamhi et al 2015). Brain titers of OA, DA, and 5HT have been found to be either correlated with or causally linked to diverse social behaviors, including polyethism in honey bees (Barron and Robinson 2005; Scheiner et al 2006) and behavioral development, subcaste-related division of labor, and colony foundation in ants, as well as motor output (Akasaka et al 2010; Mustard et al 2010). OA in ants, for example, has been correlated with division of labor by polymorphic workers in the leafcutter Acromyrmex echinatior (Smith et al 2013) and causally linked to major worker aggression in the Australian weaver ant Oecophylla smaragdina (Kamhi et al 2015).…”

Section: Introductionmentioning

confidence: 99%

Age, worksite location, neuromodulators, and task performance in the ant Pheidole dentata

Giraldo

Rusakov

Diloreto

et al. 2016

Behav Ecol Sociobiol

View full text Add to dashboard Cite

Social insect workers modify task performance according to age-related schedules of behavioral development, and/or changing colony labor requirements based on flexible responses that may be independent of age. Using known-age minor workers of the ant Pheidole dentata throughout 68% of their 140-day laboratory lifespan, we asked whether workers found inside or outside the nest differed in task performance and if behaviors were correlated with and/or causally linked to changes in brain serotonin (5HT) and dopamine (DA). Our results suggest that task performance patterns of individually assayed minors collected at these two spatially different worksites were independent of age. Outside-nest minors displayed significantly higher levels of predatory behavior and greater activity than inside-nest minors, but these groups did not differ in brood care or phototaxis. We examined the relationship of 5HT and DA to these behaviors in known-age minors by quantifying individual brain titers. Both monoamines did not increase significantly from 20 to 95 days of age. DA did not appear to directly regulate worksite location, although titers were significantly higher in outside-nest than inside-nest workers. Pharmacological depletion of 5HT did not affect nursing, predation, phototaxis or activity. Our results suggest that worker task capabilities are independent of age beyond 20 days, and only predatory behavior can be consistently predicted by spatial location. This could reflect worker flexibility or variability in the behavior of individuals collected at each location, which could be influenced by complex interactions between age, worksite location, social interactions, neuromodulators, and other environmental and internal regulators of behavior.

show abstract

“…In insects, DA plays central regulation roles, especially in neural networks controlling locomotor activity [24], [25] and many stereotyped behaviors [26], [27]. In D. melanogaster , dopaminergic neurons modulate pheromone responses [28] and in the honeybee, queen pheromone modifies dopamine-induced behavioral effects via direct interaction with DA receptors [29], [30].…”

Section: Introductionmentioning

confidence: 99%

Involvement of the G-Protein-Coupled Dopamine/Ecdysteroid Receptor DopEcR in the Behavioral Response to Sex Pheromone in an Insect

Abrieux

Debernard²,

Maria³

et al. 2013

PLoS ONE

View full text Add to dashboard Cite

Most animals including insects rely on olfaction to find their mating partners. In moths, males are attracted by female-produced sex pheromones inducing stereotyped sexual behavior. The behaviorally relevant olfactory information is processed in the primary olfactory centre, the antennal lobe (AL). Evidence is now accumulating that modulation of sex-linked behavioral output occurs through neuronal plasticity via the action of hormones and/or catecholamines. A G-protein-coupled receptor (GPCR) binding to 20-hydroxyecdysone, the main insect steroid hormone, and dopamine, has been identified in Drosophila (DmDopEcR), and was suggested to modulate neuronal signaling. In the male moth Agrotis ipsilon, the behavioral and central nervous responses to pheromone are age-dependent. To further unveil the mechanisms of this olfactory plasticity, we searched for DopEcR and tested its potential role in the behavioral response to sex pheromone in A. ipsilon males. Our results show that A. ipsilon DopEcR (named AipsDopEcR) is predominantly expressed in the nervous system. The corresponding protein was detected immunohistochemically in the ALs and higher brain centers including the mushroom bodies. Moreover, AipsDopEcR expression increased with age. Using a strategy of RNA interference, we also show that silencing of AipsDopEcR inhibited the behavioral response to sex pheromone in wind tunnel experiments. Altogether our results indicate that this GPCR is involved in the expression of sexual behavior in the male moth, probably by modulating the central nervous processing of sex pheromone through the action of one or both of its ligands.

show abstract

Dopamine enhances locomotor activity for mating in male honeybees (Apis mellifera L.)

Cited by 40 publications

References 40 publications

Regulation of the brain dopaminergic system by juvenile hormone in honey bee males (Apis mellifera L.)

Regulation of the brain dopaminergic system by juvenile hormone in honey bee males (Apis mellifera L.)

Age, worksite location, neuromodulators, and task performance in the ant Pheidole dentata

Involvement of the G-Protein-Coupled Dopamine/Ecdysteroid Receptor DopEcR in the Behavioral Response to Sex Pheromone in an Insect

Contact Info

Product

Resources

About