Dopamine facilitates associative memory encoding in the entorhinal cortex

Lee, Jason Y.; Jun, Heechul; Soma, Shogo; Nakazono, Tomoaki; Shiraiwa, Kaori; Dasgupta, Ananya; Nakagawa, Taro; Xie, Jiayun; Chavez, Jasmine; Romo, Rodrigo; Yungblut, Sandra; Hagihara, Meiko; Murata, Katsumi; Igarashi, Ken

doi:10.1038/s41586-021-03948-8

Cited by 90 publications

(89 citation statements)

References 35 publications

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“…This suggests that LEC is only required for behavior requiring difficult odor discrimination. In contrast, more recent work in mice found that LEC muscimol infusion ( Lee et al, 2021 ) or optogenetic suppression of LEC inputs to CA1 ( Li et al, 2017 ) degraded performance in simple, two-odorant discrimination tasks. Moreover, the LEC and fan cells in particular appear to play a critical role in the learning of new olfactory cue–reward associations ( Igarashi et al, 2014 ; Lee et al, 2021 ).…”

Section: Discussionmentioning

confidence: 90%

“…In contrast, more recent work in mice found that LEC muscimol infusion ( Lee et al, 2021 ) or optogenetic suppression of LEC inputs to CA1 ( Li et al, 2017 ) degraded performance in simple, two-odorant discrimination tasks. Moreover, the LEC and fan cells in particular appear to play a critical role in the learning of new olfactory cue–reward associations ( Igarashi et al, 2014 ; Lee et al, 2021 ). We found that optogenetic suppression of the LEC abolished rapid behavioral discrimination of both odor identity and intensity, indicating that the LEC is essential for simple odor-guided behavior.…”

Section: Discussionmentioning

confidence: 90%

“…LEC neurons respond in an odor-specific fashion ( Leitner et al, 2016 ; Woods et al, 2020 ; Xu and Wilson, 2012 ) and calcium imaging in anesthetized mice revealed that fan cells respond more selectively to odors than pyramidal cells ( Leitner et al, 2016 ). However, the role of LEC in odor discrimination has been debated ( Chapuis et al, 2013 ; Lee et al, 2021 ; Li et al, 2017 ) and the coding of odor identity and intensity by fan and pyramidal cells in awake animals has not been established.…”

Section: Introductionmentioning

confidence: 99%

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Rapid odor processing by layer 2 subcircuits in lateral entorhinal cortex

Bitzenhofer

Westeinde

Zhang

et al. 2022

eLife

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Olfactory information is encoded in lateral entorhinal cortex (LEC) by two classes of layer 2 (L2) principal neurons: fan and pyramidal cells. However, the functional properties of L2 cells and how they contribute to odor coding are unclear. Here, we show in awake mice that L2 cells respond to odors early during single sniffs and that LEC is essential for rapid discrimination of both odor identity and intensity. Population analyses of L2 ensembles reveals that rate coding distinguishes odor identity, but firing rates are only weakly concentration-dependent and changes in spike timing can represent odor intensity. L2 principal cells differ in afferent olfactory input and connectivity with inhibitory circuits and the relative timing of pyramidal and fan cell spikes provides a temporal code for odor intensity. Downstream, intensity is encoded purely by spike timing in hippocampal CA1. Together, these results reveal the unique processing of odor information by LEC subcircuits and highlight the importance of temporal coding in higher olfactory areas.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

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Rapid odor processing by layer 2 subcircuits in lateral entorhinal cortex

Bitzenhofer

Westeinde

Zhang

et al. 2022

eLife

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“…In contrast, the existing cytoarchitectonic laminar definition in rodents has recently been complemented by integrating the distribution of molecular and genetic markers that coincide well with traditional cytoarchitecture-based layer definitions (Sürmeli et al, 2015;Ohara et al, 2018Ohara et al, , 2019Kobro-Flatmoen and Witter, 2019). This has facilitated recent detailed functional studies in both MEC (Kitamura et al, 2014(Kitamura et al, , 2015(Kitamura et al, , 2017Kanter et al, 2017;Rowland et al, 2018;Zutshi et al, 2018) and LEC (Kobro-Flatmoen et al, 2016;Leitner et al, 2016;Vandrey et al, 2020;Lee et al, 2021). Since our aim is to examine the inter-species differences and homology of the EC, it is essential to use the same laminar definition among species.…”

Section: Laminar Definition Of Monkey Entorhinal Cortex Based On Purkinje Cell Protein 4 Labelingmentioning

confidence: 99%

“…In contrast, neurons in the superficial-sublayer Va express E twenty-six variant1 (Etv1), and are the major origin of EC outputs. Although EC layer VI neurons are still understudied, it is evident that cell-type-specific approaches with genetic tools have immensely advanced our understandings of the organization of complicated entorhinal circuits and their functions ( Kitamura et al, 2014 , 2015 , 2017 ; Kobro-Flatmoen et al, 2016 ; Leitner et al, 2016 ; Kanter et al, 2017 ; Rowland et al, 2018 ; Zutshi et al, 2018 ; Vandrey et al, 2020 ; Lee et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Laminar Organization of the Entorhinal Cortex in Macaque Monkeys Based on Cell-Type-Specific Markers and Connectivity

Ohara

Yoshino

Kimura

et al. 2021

Front. Neural Circuits

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The entorhinal cortex (EC) is a major gateway between the hippocampus and telencephalic structures, and plays a critical role in memory and navigation. Through the use of various molecular markers and genetic tools, neuron types constituting EC are well studied in rodents, and their layer-dependent distributions, connections, and functions have also been characterized. In primates, however, such cell-type-specific understandings are lagging. To bridge the gap between rodents and primates, here we provide the first cell-type-based global map of EC in macaque monkeys. The laminar organization of the monkey EC was systematically examined and compared with that of the rodent EC by using immunohistochemistry for molecular markers which have been well characterized in the rodent EC: reelin, calbindin, and Purkinje cell protein 4 (PCP4). We further employed retrograde neuron labeling from the nucleus accumbens and amygdala to identify the EC output layer. This cell-type-based approach enabled us to apply the latest laminar definition of rodent EC to monkeys. Based on the similarity of the laminar organization, the monkey EC can be divided into two subdivisions: rostral and caudal EC. These subdivisions likely correspond to the lateral and medial EC in rodents, respectively. In addition, we found an overall absence of a clear laminar arrangement of layer V neurons in the rostral EC, unlike rodents. The cell-type-based architectural map provided in this study will accelerate the application of genetic tools in monkeys for better understanding of the role of EC in memory and navigation.

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Synergistic Coordination Effect and Metal‐Support Interaction Engineering of Single‐Atom Mn–N₂ Sites for Boosting Sensitive and Selective Dopamine Biosensing in Human Serum

Zhao,

Yang,

Wang

et al. 2024

Small

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Coordination environment of metal atoms is core for designing high‐performance single‐atom catalysts (SACs), while metal‐support interaction also has an important effect on structure‐function relationship. Nevertheless, the interaction effect of metal‐support is mostly ignored. Through synergistic regulation of coordination environment and metal‐support interaction, Mn SAC with atom‐dispersed Mn–N2 sites on dopamine (DA) support is synthesized for sensitive and selective DA oxidation based on theoretical calculations and experimental explorations. MnN2 presents the more optimal catalytic site for DA oxidation than other coordination conditions, enhancing sensitivity including a wide range, a low limit of detection, and particularly a very low catalytic potential. The construction of Mn–N2 active sites on DA carbon promotes the coupling between Mn metal atoms and DA support, decreasing work function, facilitating electron exchange, shortening response time, and boosting selectivity. Both the catalytic mechanism of Mn SAC toward DA and the relation construction of catalyst's structure and catalytic function are established.

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Dopamine facilitates associative memory encoding in the entorhinal cortex

Cited by 90 publications

References 35 publications

Rapid odor processing by layer 2 subcircuits in lateral entorhinal cortex

Rapid odor processing by layer 2 subcircuits in lateral entorhinal cortex

Laminar Organization of the Entorhinal Cortex in Macaque Monkeys Based on Cell-Type-Specific Markers and Connectivity

Synergistic Coordination Effect and Metal‐Support Interaction Engineering of Single‐Atom Mn–N₂ Sites for Boosting Sensitive and Selective Dopamine Biosensing in Human Serum

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Dopamine facilitates associative memory encoding in the entorhinal cortex

Cited by 90 publications

References 35 publications

Rapid odor processing by layer 2 subcircuits in lateral entorhinal cortex

Rapid odor processing by layer 2 subcircuits in lateral entorhinal cortex

Laminar Organization of the Entorhinal Cortex in Macaque Monkeys Based on Cell-Type-Specific Markers and Connectivity

Synergistic Coordination Effect and Metal‐Support Interaction Engineering of Single‐Atom Mn–N2 Sites for Boosting Sensitive and Selective Dopamine Biosensing in Human Serum

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Product

Resources

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Synergistic Coordination Effect and Metal‐Support Interaction Engineering of Single‐Atom Mn–N₂ Sites for Boosting Sensitive and Selective Dopamine Biosensing in Human Serum