Dopamine in the pituitary adaptation to starvation in man

Jung, R. T.; Rosenstock, J; Wood, Susan M.; Birch, G. G.; Chalmers, R. J.; Mashiter, Κ.; Joplin, G. F.

doi:10.1136/pgmj.61.717.571

Postgraduate Medical Journal

1985

DOI: 10.1136/pgmj.61.717.571

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Dopamine in the pituitary adaptation to starvation in man

R. T. Jung

J Rosenstock

Susan M. Wood

et al.

Abstract: Summary:To investigate the role of the dopaminergic system in the pituitary adaptation to energy deprivation, the effect of metoclopramide, a dopamine receptor blocker, on prolactin (PRL), TSH, FSH and LH secretion was investigated in 6 healthy men in the fed state and at 36 h starvation. All underwent a further 36 h of starvation on a separate occasion to assess the effect of starvation on the TSH and PRL responses to TRH and the LH and FSH responses to gonadotrophin releasing hormone (GnRH). In all subjects … Show more

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Cited by 2 publications

References 15 publications

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Effects of Metoclopramide on Fasting-Induced TSH Suppression

Samuels

Kramer²

1996

Thyroid

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Short-term caloric deprivation leads to suppression of TSH secretion in healthy subjects, but the mechanism of this effect is unknown. Since dopamine inhibits TSH secretion at physiologic levels, increased endogenous dopamine activity may cause the TSH suppression observed during fasting. To test this hypothesis, 11 healthy subjects underwent four studies: (1) Baseline-subjects were allowed ad libitum food. (2) MCP-subjects were allowed ad libitum food and received iv metoclopramide (MCP) at 30 micrograms/kg/h over 48 h. (3) Fasting-subjects received no caloric intake for 56 h. (4) Fasting+MCP-subjects fasted for 56 h, and received iv MCP during the final 48 h of the study. Serum TSH levels were measured every 15 min during the final 24 h of each study, and a TRH stimulation test was performed at the conclusion of each study: 56 h of fasting decreased 24 h mean TSH levels and TSH pulse amplitude by 40%, with blunting of the TSH response to TRH. MCP infusions increased 24 h mean TSH levels and TSH pulse amplitude 26-34%, with no differences between the fasting and nonfasting studies. MCP infusions did not normalize TSH levels, TSH responses to TRH, or serum T3 levels during fasting. These data suggest that endogenous dopaminergic activity does not play a major role in fasting-induced TSH suppression in healthy subjects.

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Effects of Metoclopramide on Fasting-Induced TSH Suppression

Samuels

Kramer²

1996

Thyroid

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The Role of a Highly Sensitive Amplified Enzyme Immunoassay for Thyrotrophin in the Evaluation of Thyrotroph Function in Hypopituitary Patients

Blunt

Woods

Joplin

et al. 1988

Clinical Endocrinology

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Using a highly sensitive amplified enzyme-linked immunoassay (AEIA) for thyrotrophin (TSH), we have assessed the ability of a single basal measurement of TSH to predict the subsequent response of TSH to TRH in a group of 11 patients with known pituitary pathology and some evidence of hypopituitarism. All patients were clinically euthyroid. Basal levels of AEIA-TSH ranged from less than 0.2 mU/l ('undetectable') to 0.9 mU/l; within this range there was no correlation with the subsequent TSH levels at 30 min in the TRH test. The TSH response in the TRH test did not correlate with the direct measurements of prevailing thyroid hormone levels (Total T4 or Free T4). We suggest that in patients with pituitary disease, the formal TRH test yields additional information regarding residual thyrotroph function that cannot reliably be predicted by a single basal TSH value, even when measured by a sensitive method. The current and potential thyroid status in patients with hypopituitarism must continue to rest on the overall picture provided by clinical assessment, direct measurement of thyroid hormones and the TRH test response. A basal TSH alone gives little useful information regarding thyroid status in such patients.

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Dopamine in the pituitary adaptation to starvation in man

Cited by 2 publications

References 15 publications

Effects of Metoclopramide on Fasting-Induced TSH Suppression

Effects of Metoclopramide on Fasting-Induced TSH Suppression

The Role of a Highly Sensitive Amplified Enzyme Immunoassay for Thyrotrophin in the Evaluation of Thyrotroph Function in Hypopituitary Patients

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