1976
DOI: 10.1038/259584a0
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Dopamine-like renal and mesenteric vasodilation caused by apomorphine 6-propylnorapomorphine and 2-amino-6, 7-dihydroxy-l,2,3,4-tetrahydronaphthalene

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Cited by 46 publications
(3 citation statements)
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“…Despite the fall in organ perfusion pressure and with little change in cardiac output, dopexamine produced a rise in renal and mesenteric blood flows, suggesting that the degree of vasodilatation in these organs exceeded that of the general circulation. Both these vascular beds have been shown to contain vascular dopamine (DA,)-receptors, the stimulation of which causes vasodilatation (McNay & Goldberg, 1966;Yeh et al, 1969;Crumley et al, 1976;Hilditch & Drew, 1983) and since the location of DA,-receptors is highly regionalized (Goldberg, 1972), local effects would be expected to predominate. In the anaesthetized dog, it was confirmed that dopexamine-induced renal vasodilatation resulted from this mechanism, since the selective DA,-receptor antagonist, bulbocapnine (Setler et al, 1975;Shepperson et al, 1982) attenuated the response.…”
Section: Discussionmentioning
confidence: 99%
“…Despite the fall in organ perfusion pressure and with little change in cardiac output, dopexamine produced a rise in renal and mesenteric blood flows, suggesting that the degree of vasodilatation in these organs exceeded that of the general circulation. Both these vascular beds have been shown to contain vascular dopamine (DA,)-receptors, the stimulation of which causes vasodilatation (McNay & Goldberg, 1966;Yeh et al, 1969;Crumley et al, 1976;Hilditch & Drew, 1983) and since the location of DA,-receptors is highly regionalized (Goldberg, 1972), local effects would be expected to predominate. In the anaesthetized dog, it was confirmed that dopexamine-induced renal vasodilatation resulted from this mechanism, since the selective DA,-receptor antagonist, bulbocapnine (Setler et al, 1975;Shepperson et al, 1982) attenuated the response.…”
Section: Discussionmentioning
confidence: 99%
“…Experimentalists investigated a large number of dopamine (DA) analogs. On this basis, key factors for the molecular structure of central (postsynaptic) DA receptor agonists were suggested in the literature [7,8].…”
Section: Introductionmentioning
confidence: 99%
“…Peripheral dopamine receptors are classified into two biochemically and pharmacologically distinct subtypes. Stimulation of the dopamine DAI receptor induces vasodilatation, and this vascular relaxant effect is conspicuous especially in the renal and mesenteric vascular beds (Crumley et al 1976). The dopamine DA2 receptor is located presynaptically at the sympathetic nerve ending and suppresses noradrenaline release (Lokhandwala & Barrett 1983).…”
mentioning
confidence: 99%