Dopamine Mediates Context-Dependent Modulation of Sensory Plasticity in C. elegans

Kindt, Katie S.; Quast, Kathleen B.; Giles, Andrew C.; De, Subhajyoti; Hendrey, Dan; Nicastro, Ian; Rankin, Catharine H.; Schafer, William R.

doi:10.1016/j.neuron.2007.07.023

Cited by 161 publications

(187 citation statements)

References 86 publications

(116 reference statements)

Supporting

Mentioning

179

Contrasting

Unclassified

Order By: Relevance

“…1B). A similar reduction in calcium response was seen following repeated stimulation of the posterior touch cell, PLM (Kindt et al 2007). Thus, attenuation of touch cell excitability with repeated activation correlates with decreased behavioral responding from tap habituation.…”

Section: Nonassociative Learning Mechanosensory Habituationsupporting

confidence: 57%

“…When tested in the absence of the bacteria, the proportion of worms responding to tap decreased more rapidly with repeated stimulation at a 10-sec ISI than did worms tested in the presence of bacteria, i.e., worms habituated to tap faster when stimulated off of food (note that in this case, the effect was on response frequency, there was no difference in habituation of response magnitude, suggesting that there is independent regulation of habituation of response frequency and response magnitude) (Kindt et al 2007). Mutants in which dopaminergic signaling was disrupted habituated to tap with the rapid kinetics of wildtype worms tested off of food (Sanyal et al 2004;Kindt et al 2007). It was hypothesized that the texture of bacterial lawns stimulated dopamine release, which altered the functional properties of the touch cells through the D1-like dopamine receptor, DOP-1 (Sawin et al 2000;Sanyal et al 2004;Kindt et al 2007).…”

Section: Effect Of Context In Short-term Mechanosensory Habituationmentioning

confidence: 95%

“…Mutants in which dopaminergic signaling was disrupted habituated to tap with the rapid kinetics of wildtype worms tested off of food (Sanyal et al 2004;Kindt et al 2007). It was hypothesized that the texture of bacterial lawns stimulated dopamine release, which altered the functional properties of the touch cells through the D1-like dopamine receptor, DOP-1 (Sawin et al 2000;Sanyal et al 2004;Kindt et al 2007). Calcium-imaging experiments in various mutant backgrounds revealed that dopamine slowed the decrement of touch-evoked calcium currents in ALM via intracellular calcium release and PKC activity downstream from a Gq/PLC-b signaling cascade (Kindt et al 2007).…”

Section: Effect Of Context In Short-term Mechanosensory Habituationmentioning

confidence: 99%

“…It was hypothesized that the texture of bacterial lawns stimulated dopamine release, which altered the functional properties of the touch cells through the D1-like dopamine receptor, DOP-1 (Sawin et al 2000;Sanyal et al 2004;Kindt et al 2007). Calcium-imaging experiments in various mutant backgrounds revealed that dopamine slowed the decrement of touch-evoked calcium currents in ALM via intracellular calcium release and PKC activity downstream from a Gq/PLC-b signaling cascade (Kindt et al 2007). Thus, more rapid habituation kinetics in the The context in which habituation occurs can also influence behavior in subsequent tests.…”

Section: Effect Of Context In Short-term Mechanosensory Habituationmentioning

confidence: 99%

See 3 more Smart Citations

An elegant mind: Learning and memory in Caenorhabditis elegans

Ardiel¹,

Rankin²

2010

Learn. Mem.

281

191

View full text Add to dashboard Cite

This article reviews the literature on learning and memory in the soil-dwelling nematode Caenorhabditis elegans. Paradigms include nonassociative learning, associative learning, and imprinting, as worms have been shown to habituate to mechanical and chemical stimuli, as well as learn the smells, tastes, temperatures, and oxygen levels that predict aversive chemicals or the presence or absence of food. In each case, the neural circuit underlying the behavior has been at least partially described, and forward and reverse genetics are being used to elucidate the underlying cellular and molecular mechanisms. Several genes have been identified with no known role other than mediating behavior plasticity.Historically, it was believed that even if they were capable of learning, the nervous systems of invertebrates were too different to be instructive on human cognition. In the 1960s, Kandel and colleagues began studying learning in the marine mollusc Aplysia (Kandel and Tauc 1965). Using this system, they were able to relate behavioral plasticity to changes at specific synapses of identified neurons, and began a biochemical analysis of these neuronal changes, uncovering a role for cAMP, PKA, and CREB. In the 1970s, Benzer and colleagues began a genetic dissection of learning in the fruit fly Drosophila melanogaster (Quinn et al. 1974;Dudai et al. 1976). They established an associative learning assay (Quinn et al. 1974) and conducted a forward genetic screen, identifying the first learning mutant, dunce (Dudai et al. 1976). Since then, many genes have been cloned, and the biological basis of learning has proven to be highly conserved (Barco et al. 2006;Skoulakis and Grammenoudi 2006). Today there is no question as to the relevance of invertebrate research in the field of learning and memory.At about the same time that Kandel was beginning his work with Aplysia, Sydney Brenner chose Caenorhabditis elegans as the organism in which to study development and the nervous system (Brenner 1974). Today this transparent nematode is the world's best understood animal. It's small size ( 1 mm), short life cycle (,3 d), and ease of cultivation make it perfect for the laboratory, and its mode of reproduction is ideal for genetic analysis-selffertilizing hermaphrodites can be easily inbred or crossed with males. The genome has been mapped and sequenced, and there are thousands of mutants and RNAi constructs readily available for researchers. Furthermore, C. elegans has an invariant cell lineage and relatively simple morphology-959 cells make up the entire adult hermaphrodite (Sulston and Horvitz 1977;Sulston et al. 1983). Using serial section electron micrographs, White et al. (1986) were able to construct a neural wiring diagram of the hermaphrodite's 302 neurons. They found about 5000 chemical synapses, 600 gap junctions, and 2000 neuromuscular junctions, the location of which were fairly consistent between animals. With its invariant cell lineage and reproducible connectome, C. elegans was initially viewed as a genetically hardwired ...

show abstract

Section: Nonassociative Learning Mechanosensory Habituationsupporting

confidence: 57%

Section: Effect Of Context In Short-term Mechanosensory Habituationmentioning

confidence: 95%

Section: Effect Of Context In Short-term Mechanosensory Habituationmentioning

confidence: 99%

Section: Effect Of Context In Short-term Mechanosensory Habituationmentioning

confidence: 99%

See 2 more Smart Citations

An elegant mind: Learning and memory in Caenorhabditis elegans

Ardiel¹,

Rankin²

2010

Learn. Mem.

281

191

View full text Add to dashboard Cite

show abstract

“…Expression of high affinity cameleons in Caenorhabditis elegans buffers sufficient calcium (Suzuki et al, 2003) to affect behavior (Kindt et al, 2007) and rescues calcium-binding protein knockout phenotypes (Ferkey et al, 2007 (Neher, 1995) such that…”

Section: Intrinsic Properties That Influence the Performance Of Gecismentioning

confidence: 99%

Reporting neural activity with genetically encoded calcium indicators

2008

View full text Add to dashboard Cite

Genetically encoded calcium indicators (GECIs), based on recombinant fluorescent proteins, have been engineered to observe calcium transients in living cells and organisms. Through observation of calcium, these indicators also report neural activity. We review progress in GECI construction and application, particularly toward in vivo monitoring of sparse action potentials (APs). We summarize the extrinsic and intrinsic factors that influence GECI performance. A simple model of GECI response to AP firing demonstrates the relative significance of these factors. We recommend a standardized protocol for evaluating GECIs in a physiologically relevant context. A potential method of simultaneous optical control and recording of neuronal circuits is presented.

show abstract

Habituation Is More Than Learning to Ignore: Multiple Mechanisms Serve to Facilitate Shifts in Behavioral Strategy

McDiarmid

Rankin

2019

BioEssays

View full text Add to dashboard Cite

Recent work indicates that there are distinct response habituation mechanisms that can be recruited by different stimulation rates and that can underlie different components (e.g., the duration or speed) of a single behavioral response. These findings raise the question: why is “the simplest form of learning” so complicated mechanistically? Beyond evolutionary selection for robustness of plasticity in learning to ignore, it is proposed in this article that multiple mechanisms of habituation have evolved to streamline shifts in ongoing behavioral strategy. Then, speculations are offered regarding the implications of this reconceptualization of habituation for approaching the analysis of mechanisms of more complex forms of learning and memory.

show abstract

Dopamine Mediates Context-Dependent Modulation of Sensory Plasticity in C. elegans

Cited by 161 publications

References 86 publications

An elegant mind: Learning and memory in Caenorhabditis elegans

An elegant mind: Learning and memory in Caenorhabditis elegans

Reporting neural activity with genetically encoded calcium indicators

Habituation Is More Than Learning to Ignore: Multiple Mechanisms Serve to Facilitate Shifts in Behavioral Strategy

Contact Info

Product

Resources

About