Dopamine modulates diurnal and circadian rhythms of protein phosphorylation in photoreceptor cells of mouse retina

Pozdeyev, Nikita; Tosini, Gianluca; Li, Li; Ali, Fatima; Rozov, Stanislav; Lee, Rehwa H.; Iuvone, P. Michael

doi:10.1111/j.1460-9568.2008.06224.x

Cited by 70 publications

(64 citation statements)

References 52 publications

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“…Harvested retinas were immediately frozen on dry ice and stored at −80°C. The frozen retinas were processed using high-performance liquid chromatography (HPLC), as previously described (Nir et al, 2000; Pozdeyev et al, 2008). Right and left eyes of mice with a normal visual environment were pooled together for analysis, while eyes of FD mice were analyzed individually.…”

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confidence: 99%

ON pathway mutations increase susceptibility to form-deprivation myopia

Chakraborty

Park

Hanif

et al. 2015

Experimental Eye Research

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The ON pathway mutation in nob mice is associated with altered refractive development, and an increased susceptibility to form-deprivation (FD) myopia. In this study, we used mGluR6−/− mice, another ON pathway mutant, to determine whether the nob phenotype was due to the Nyx mutation or abnormal ON pathway transmission. Refractive development under a normal visual environment for mGluR6−/− and age-matched wild-type (WT) mice was measured every 2 weeks from 4 to 16 weeks of age. The response to monocular FD from 4 weeks of age was measured weekly in a separate cohort of mice. Refraction and ocular biometry were obtained using a photorefractor and optical coherence tomography. Retinas were harvested at 16 weeks, and analyzed for dopamine (DA) and DOPAC using high-performance liquid chromatography. Under normal conditions, mGluR6−/− mice were significantly more myopic than their WT controls (refraction at 12 weeks; WT: 9.40 ± 0.16 D, mGluR6−/−: 6.91 ± 0.38 D). Similar to nob mice, two weeks of FD resulted in a significant myopic shift of −5.57 ± 0.72 D in mGluR6−/− mice compared to −1.66 ± 0.19 D in WT animals. No significant axial length changes were observed with either normal or FD visual conditions. At 16 weeks, mGluR6−/− retinas showed significantly lower DOPAC levels (111.2 ± 33.0 pg/mg) compared to their WT counterparts (197.5 ± 11.2 pg/mg). Retinal DA levels were similar between the different genotypes. Our results indicate that reduced retinal DA metabolism/turnover may be associated with increased susceptibility to myopia in mice with ON pathway defect mutations.

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confidence: 99%

ON pathway mutations increase susceptibility to form-deprivation myopia

Chakraborty

Park

Hanif

et al. 2015

Experimental Eye Research

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“…Dopamine the reward-motivated neurotransmitter undergoes down regulation during stress condition in both light and dark exposures, revealing its direct association with sleep and stress. The observation also emphasizes its direct role in circadian cycle associated disturbances, as it was known that dopamine modulates diurnal and circadian rhythms in photoreceptor cells of mouse retina [11]. Serotonin, the other major neurotransmitter involved in cognitive functions was also found decreased in the disturbed cerebrum due to stress as it has been shown that serotonin has direct association with sleep as serotonin knockout mice exhibit more wakefulness [12].…”

Section: Discussionmentioning

confidence: 95%

Role of Neurotransmitter and Behavioral Changes in Mice due to Light- Dark Stress

Al-Asmari¹,

Riyasdeen²,

Al-Shahrani³

et al. 2015

Neurochem Neuropharm

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Light-dark cycle has an evident role in maintaining the circadian rhythm of complex living organisms. Disturbance of light-dark cycle has an effective role in distressing the normal functions of living organisms. In this study we have analyzed the behavioral changes and role of neurotransmitter in mice due to light-dark cycle disturbances. Batches of animals were exposed to continuous light and dark conditions for 1, 2, 3, 4 and 5 days. The physiological behavior analyses such as vertical, horizontal, ambulatory and response to light-dark exposures were recorded in the disturbed and control animals. Also the role of neurotransmitter such as Dopamine, 5-HT, 5-HIAA and Homovanillic acid were estimated in the disturbed and control animal nervous tissues such as cerebrum, cerebellum and brain stem. Based on the behavioral analysis it was found that continuous light exposures have increased the horizontal and ambulatory movement of mice more significantly than the continuous dark exposed animal upon comparison with normal 12-12 dark-light exposed animals. Also the continuous light exposed animals showed an aversion to light and liking to dark upon light-dark visit but the vice versa was not found with the dark exposed animals. Dopamines and 5-HT were found down regulated in both the light and dark exposed animals significantly when compared to the normally housed animals. The identified changes in behavioral and neurotransmitter level in mice due to light-dark disturbances are impacting the fact of association of stress, sleep and circadian rhythm in mice.

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“…For this reason, the relationship between severity of depression and CLOCK variants cannot be considered as a direct one. Nevertheless, for a better understanding of the possible influence of clock genes on depression, future studies should include other clock genes, haplotypes, and ideally the neurotransmitter systems that this molecular machinery are potentially influencing (Cuesta et al, 2008;Hampp et al, 2008;Imbesi et al, 2009;Pozdeyev et al, 2008;Yujnovsky et al, 2006).…”

Section: Discussionmentioning

confidence: 98%

3111T/C CLOCKGENE POLYMORPHISM IS NOT ASSOCIATED WITH SLEEP DISTURBANCES IN UNTREATED DEPRESSED PATIENTS

Serretti

Gaspar-Barba²,

Calati

et al. 2010

Chronobiology International

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Sleep patterns, frequently altered in depression, have been hypothesized to be under genetic control. The circadian locomotor output cycles kaput (CLOCK) T3111C variant has been studied in association with sleep disturbances in depressed patients. The aim of this study was to investigate possible effects of T3111C CLOCK on insomnia, daytime sleepiness, sleep quality, and depression severity in a sample of 100 major depressive disorder patients. Inclusion criteria were: major depressive disorder, drug-free for any antidepressant and/or benzodiazepines for at least four weeks previously to the study, and a minimum score of >17 on the Hamilton Rating Scale for Depression. The Morningness-Eveningness Questionnaire, Epworth Sleepiness Scale, Athens Insomnia Scale, and Pittsburgh Sleep Quality Index were applied. No significant difference was found concerning genotype or allele groups and Hamilton Rating Scale for Depression items or clusters. No difference was found between genotypes and comorbidity, chronotype distribution, Epworth Sleepiness Scale, Athens Insomnia Scale, or Pittsburgh Sleep Quality Index total scores. Overall, the present findings did not support the hypothesis of an effect of the T3111C CLOCK variant on sleep disturbances in major depressive disorder. Further analysis of clock machinery will clarify the contribution of clock genes to the maintenance of mental health.

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Dopamine modulates diurnal and circadian rhythms of protein phosphorylation in photoreceptor cells of mouse retina

Cited by 70 publications

References 52 publications

ON pathway mutations increase susceptibility to form-deprivation myopia

ON pathway mutations increase susceptibility to form-deprivation myopia

Role of Neurotransmitter and Behavioral Changes in Mice due to Light- Dark Stress

3111T/C CLOCKGENE POLYMORPHISM IS NOT ASSOCIATED WITH SLEEP DISTURBANCES IN UNTREATED DEPRESSED PATIENTS

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