Dopamine modulates visual threat processing in the superior colliculus via D2 receptors

Montardy, Quentin; Zhou, Zheng; Li, Lei; Yang, Qingning; Lei, Zhuogui; Feng, Xiaolong; Chen, Shanping; Shi, Qianqian; Zhang, Huiqi; Chen, Shuran; Zhang, Zhijian; Zhao, Binghao; Xu, Fuqiang; Lu, Zhonghua; Wang, Liping

doi:10.1016/j.isci.2022.104388

Cited by 7 publications

(3 citation statements)

References 70 publications

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“…As we observed when discussing stimulus prioritization in the fish tectum, the study of predation provides fertile ground to dissect the organizational principles underlying sensory motor transformation in the SC. This is supported by a plethora of recent studies focusing on how the superior colliculus or optic tectum control ethological behaviours both in mice and in fish [ 17∗ , 18∗ , 19 , 20 , 21 , 22 , 23 , 24 ]. Since recent reviews have already amply and competently discussed the role of the SC in predatory evasion and escape [ 16 ], here we will focus specifically on recent advances regarding the role of the SC in predation.…”

Section: Action Intracollicular Circuit Motives Underpinning Sensorim...mentioning

confidence: 75%

Collicular circuits supporting the perceptual, motor and cognitive demands of ethological environments

de Malmazet,

Tripodi

2023

Current Opinion in Neurobiology

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Section: Action Intracollicular Circuit Motives Underpinning Sensorim...mentioning

confidence: 75%

Collicular circuits supporting the perceptual, motor and cognitive demands of ethological environments

de Malmazet,

Tripodi

2023

Current Opinion in Neurobiology

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“…110 These projections provide dopaminergic inputs that modulate visual threat processing through D2 receptors in GABAergic neurons at the intermediate and deep layers. 111 The context-dependent innate behaviors initiated by SC neurons are accompanied by stereotypical cardiovascular and respiratory responses, which are mediated by projections of the SC to neurons in the medullary gigantocellular reticular nucleus projecting to the spinal cord. 112…”

Section: Role In Emotional Responsesmentioning

confidence: 99%

What Are the Functions of the Superior Colliculus and Its Involvement in Neurologic Disorders?

Benarroch

2023

Neurology

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The superior colliculus (SC) is an evolutionary conserved sensorimotor structure that is specialized for detecting, localizing, and orienting toward environmental events and has a critical role in orienting motor responses, visuospatial attention, and perceptual decision-making.1-8 The SC consists of a superficial layer that receives visual inputs and intermediate and deep motor layers that initiate saccades and other orienting movements toward the contralateral hemispace. Modern molecular and genetic methods combined with behavioral assessments have provided further understanding of the cell types, circuits, and functions of the SC (reviewed in ref. 9,10). The SC is affected by α-synuclein and tau neuropathology in Lewy body dementia (LBD),11 shows abnormal responses to visual stimuli in Parkinson disease (PD),12,13 may contribute to impaired saccades in progressive supranuclear palsy (PSP),14 and may be involved in the pathophysiology of cervical dystonia.15,16 This brief review will focus on recent concepts on the functional organization and connectivity of the SC that are relevant to understand the pathophysiology of these and other neurologic disorders.

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“…The superior colliculus receives, in addition to inputs from the retina, input from a large proportion of the nervous system (28)(29)(30)(31)(32)(33). These include inputs from the cortex (CTX), basal ganglia, thalamus (TH), and midbrain (MB) that provide information about context, internal state, or prior experience necessary to appropriately adjust an animal's response to the next exposure to the same stimulus (34)(35)(36). For example, inputs to the superior colliculus from the ventral lateral geniculate nucleus of the TH have been shown to encode anxiety levels that can be influenced by previous exposure to threat and modify the probability of responding to the next stimulus (37,38).…”

Section: Introductionmentioning

confidence: 99%

Pathway-specific inputs to the superior colliculus support flexible responses to visual threat

Li,

Kühn,

Alkislar

et al. 2023

Sci. Adv.

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Behavioral flexibility requires directing feedforward sensory information to appropriate targets. In the superior colliculus, divergent outputs orchestrate different responses to visual threats, but the circuit organization enabling the flexible routing of sensory information remains unknown. To determine this structure, we focused on inhibitory projection (Gad2) neurons. Trans-synaptic tracing and neuronal recordings revealed that Gad2 neurons projecting to the lateral geniculate nucleus (LGN) and the parabigeminal nucleus (PBG) form two separate populations, each receiving a different set of non-retinal inputs. Inhibiting the LGN- or PBG-projecting Gad2 neurons resulted in opposing effects on behavior; increasing freezing or escape probability to visual looming, respectively. Optogenetic activation of selected inputs to the LGN- and PBG-projecting Gad2 cells predictably regulated responses to visual threat. These data suggest that projection-specific sampling of brain-wide inputs provides a circuit design principle that enables visual inputs to be selectively routed to produce context-specific behavior.

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Dopamine modulates visual threat processing in the superior colliculus via D2 receptors

Cited by 7 publications

References 70 publications

Collicular circuits supporting the perceptual, motor and cognitive demands of ethological environments

Collicular circuits supporting the perceptual, motor and cognitive demands of ethological environments

What Are the Functions of the Superior Colliculus and Its Involvement in Neurologic Disorders?

Pathway-specific inputs to the superior colliculus support flexible responses to visual threat

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