Dopamine modulation of learning and memory in the prefrontal cortex: insights from studies in primates, rodents, and birds

Puig, M. Victoria; Rose, Jonas; Schmidt, Robert; Freund, Nadja

doi:10.3389/fncir.2014.00093

Cited by 154 publications

(112 citation statements)

References 213 publications

(296 reference statements)

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“…[21][22][23] Moreover, dopamine deficit, as a frequently suggested cause of PLMS, 4 also plays a key role in neurodegeneration and affects particularly the prefrontal cortex area, which regulates executive function. 24,25 Previous research suggests that executive function is a better predictor of functional decline and mortality in older women 26 ; thus, the current finding on PLMS and decline in executive function might have important clinical implications. Finally, PLMS could be a marker of sleep fragmentation, 2 and there is increasing recognition on the role of sleep disturbances in cognitive impairment.…”

Section: Discussionmentioning

confidence: 96%

Periodic Limb Movements in Sleep are Associated with Greater Cognitive Decline in Older Men without Dementia

Leng

Blackwell

Stone

et al. 2016

Sleep

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Study Objectives: To examine the association between periodic limb movements in sleep (PLMS) and change in selected aspects of cognition in community-dwelling older men. Methods: We studied 2,636 older men without dementia who underwent in-home polysomnography with measurement of the periodic limb movement index (PLMI) and periodic limb movement arousal index (PLMAI) using piezoelectric sensors. Random-effects models and logistic regression were used to examine the association between PLMI, PLMAI, and 3-to 4-y change in cognition. Results: After multivariable adjustment, men with a high PLMI had greater decline on the Trail Making Test -Part B (P trend = 0.02); those with a PLMI ≥ 30 were 48% more likely (odds ratio = 1.48, 95% confidence interval = 1.05-2.07) to experience the development of significant cognitive impairment (≥ 1 SD above mean change). Further adjustment for sleep efficiency, nocturnal hypoxemia, or dopaminergic medication use and analysis among men without Parkinson disease (n = 2,607) showed similar findings. No significant association was found for PLMAI or for Modified Mini-Mental State Examination scores. Conclusions: Among older men without dementia, higher PLMS frequency was associated with greater decline in cognition, particularly in executive function.

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Section: Discussionmentioning

confidence: 96%

Periodic Limb Movements in Sleep are Associated with Greater Cognitive Decline in Older Men without Dementia

Leng

Blackwell

Stone

et al. 2016

Sleep

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“…Given that disruption of the excitation/inhibition balance in the PFC has been associated with many aforementioned psychiatric disorders such as schizophrenia (Krause et al, 2013; Lisman, 2012; Winterer and Weinberger, 2004; Yizhar et al, 2011) and ADHD (Moll et al, 2003; Pouget et al, 2009; Won et al, 2011), the individual actions as well as cooperative effects of both transmitters on synaptic transmission, intracellular signaling, and neuronal integration within immature and mature PFC circuitry are thus critical for the execution of prefrontal functions. How NE and DA, individually or synergistically, activate their respective receptors and the effects this on prefrontal functioning at the cellular, physiological, and behavioral level has been well-studied and reviewed in the past (Arnsten, 2011; Arnsten and Pliszka, 2011; Arnsten et al, 2015a; Arnsten et al, 2012b; Berridge and Waterhouse, 2003; Berridge and Arnsten, 2013; Brennan and Arnsten, 2008; Clark and Noudoost, 2014; Puig et al, 2014; Ramos and Arnsten, 2007; Seamans and Yang, 2004; Spencer et al, 2015; Tritsch and Sabatini, 2012). Nevertheless, recent compelling evidence demonstrates that the functional interaction between NE and DA exerts powerful biological effects by activating converging synaptic pathways in PFC circuitry; however this interaction has yet to be well characterized.…”

Section: The Roles Ne and Da Play In Regulating Prefrontal Synaptimentioning

confidence: 99%

Norepinephrine versus dopamine and their interaction in modulating synaptic function in the prefrontal cortex

2016

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Among the neuromodulators that regulate prefrontal cortical circuit function, the catecholamine transmitters norepinephrine (NE) and dopamine (DA) stand out as powerful players in working memory and attention. Perturbation of either NE or DA signaling is implicated in the pathogenesis of several neuropsychiatric disorders, including attention deficit hyperactivity disorder (ADHD), post-traumatic stress disorder (PTSD), schizophrenia, and drug addiction. Although the precise mechanisms employed by NE and DA to cooperatively control prefrontal functions are not fully understood, emerging research indicates that both transmitters regulate electrical and biochemical aspects of neuronal function by modulating convergent ionic and synaptic signaling in the prefrontal cortex (PFC). This review summarizes previous studies that investigated the effects of both NE and DA on excitatory and inhibitory transmissions in the prefrontal cortical circuitry. Specifically, we focus on the functional interaction between NE and DA in prefrontal cortical local circuitry, synaptic integration, signaling pathways, and receptor properties. Although it is clear that both NE and DA innervate the PFC extensively and modulate synaptic function by activating distinctly different receptor subtypes and signaling pathways, it remains unclear how these two systems coordinate their actions to optimize PFC function for appropriate behavior. Throughout this review, we provide perspectives and highlight several critical topics for future studies.

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“…At the clinical level, various studies have also shown that ADHD patients manifest significant WM impairments (Kofler, Rapport, Bolden, Sarver, & Raiker, ; Martinussen, Hayden, Hogg‐Johnson, & Tannock, ), which may also be partially explained by the significant catecholaminergic role in WM processing (see Puig, Rose, Schmidt, & Freund, for a review). This raises the question of whether the involvement of beta oscillations in WM might also explain the WM impairments in patients with ADHD.…”

Section: Introductionmentioning

confidence: 99%

Beta band oscillatory deficits during working memory encoding in adolescents with attention‐deficit hyperactive disorder

Zammit

Muscat

2019

Eur J of Neuroscience

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Attention‐deficit hyperactivity disorder (ADHD) is a neurobehavioural disorder, characterized by symptoms of inattention and/or hyperactivity/impulsivity, in addition to various cognitive deficits, including working memory impairments. This pathology arises from a complex constellation of genetic, structural and neurotransmission abnormalities, which give rise to the aberrant electrophysiological patterns evident in patients with ADHD. Among such, findings have consistently provided support in favour of weaker power across the beta frequency range. Evidence has also emerged that beta rhythmic decrements are linked to working memory encoding. The catecholaminergic modulation of both working memory and beta oscillations may suggest that the link between the two might be rooted at the neurotransmission level. Studies have consistently shown that ADHD involves significant catecholaminergic dysregulation, which is also supported by other clinical studies that demonstrate stimulant‐induced amelioration of ADHD symptomology. In this study, we explore the possible ways that might relate ADHD, working memory, beta rhythms and catecholaminergic signalling altogether by investigating the integrity of encoding‐relevant electroencephalographic beta rhythms in medication‐naïve and stimulant‐medicated adolescent patients. The aberrant parietal and frontal encoding‐related beta rhythm revealed in the ADHD patients together with a working memory (WM) deficit as observed herein was reversed by methylphenidate in the latter case but not with regard to the beta rhythm. This finding per se raises the issue of the role played by beta rhythms in the WM deficits associated with ADHD.

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Dopamine modulation of learning and memory in the prefrontal cortex: insights from studies in primates, rodents, and birds

Cited by 154 publications

References 213 publications

Periodic Limb Movements in Sleep are Associated with Greater Cognitive Decline in Older Men without Dementia

Periodic Limb Movements in Sleep are Associated with Greater Cognitive Decline in Older Men without Dementia

Norepinephrine versus dopamine and their interaction in modulating synaptic function in the prefrontal cortex

Beta band oscillatory deficits during working memory encoding in adolescents with attention‐deficit hyperactive disorder

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