Dopamine, Psychosis, and Symptom Fluctuation: A Narrative Review

Novak, Gabriela; Seeman, Mary V.

doi:10.3390/healthcare10091713

Cited by 5 publications

(4 citation statements)

References 151 publications

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“…Dopamine (DA), an important neurotransmitter in the central nervous system, is mainly found in the hypothalamus and pituitary gland. Abnormal DA concentrations may contribute to diseases such as Alzheimer [ 114 ], PD [ 115 ], and schizophrenia [ 116 ]. In vivo electrochemistry of carbon-fiber electrode (CFE) is one of the most useful methods for tracking neurochemicals in specific brain regions.…”

Section: Application Of Implantable Electrochemical Microsensors For ...mentioning

confidence: 99%

Implantable Electrochemical Microsensors for In Vivo Monitoring of Animal Physiological Information

Zhou,

Fan

et al. 2023

Nano-Micro Lett.

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In vivo monitoring of animal physiological information plays a crucial role in promptly alerting humans to potential diseases in animals and aiding in the exploration of mechanisms underlying human diseases. Currently, implantable electrochemical microsensors have emerged as a prominent area of research. These microsensors not only fulfill the technical requirements for monitoring animal physiological information but also offer an ideal platform for integration. They have been extensively studied for their ability to monitor animal physiological information in a minimally invasive manner, characterized by their bloodless, painless features, and exceptional performance. The development of implantable electrochemical microsensors for in vivo monitoring of animal physiological information has witnessed significant scientific and technological advancements through dedicated efforts. This review commenced with a comprehensive discussion of the construction of microsensors, including the materials utilized and the methods employed for fabrication. Following this, we proceeded to explore the various implantation technologies employed for electrochemical microsensors. In addition, a comprehensive overview was provided of the various applications of implantable electrochemical microsensors, specifically in the monitoring of diseases and the investigation of disease mechanisms. Lastly, a concise conclusion was conducted on the recent advancements and significant obstacles pertaining to the practical implementation of implantable electrochemical microsensors.

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Section: Application Of Implantable Electrochemical Microsensors For ...mentioning

confidence: 99%

Implantable Electrochemical Microsensors for In Vivo Monitoring of Animal Physiological Information

Zhou,

Fan

et al. 2023

Nano-Micro Lett.

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“…Despite each condition having different etiology, most of these disorders are characterized by abnormal social behavior. Moreover, in some cases (especially in Parkinson's disease and schizophrenia) the major target of presently available therapies is the dopaminergic system [44][45][46].…”

Section: Introductionmentioning

confidence: 99%

The Role of the Dopaminergic Cells of the Median Raphe Region in the Behavior of the Male Mice

Chaves,

Török,

Fazekas

et al. 2024

Preprint

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According to previous studies the median raphe region (MRR) is known to contribute significantly to social behavior. Beside serotonin, there are reports of a small population of dopaminergic neu-rons in this region. Dopamine is linked to reward and locomotion, but very little has been known about its role in the MRR. To address that, we first confirmed the presence of dopaminergic cells in the MRR of mice (immunohistochemistry, RT-PCR) and humans (RT-PCR). Next, we used chemogenetic technology in mice containing Cre enzyme under the promoter of the dopamine transporter (DAT). With the help of an adeno-associated virus, artificial receptors were expressed in the dopaminergic cells of the MRR (DAT-MRR). Four weeks later, extensive behavioral charac-terization started 30 minutes after the injection of the artificial ligand (Clozapine-N-Oxide). Stimu-lation of DAT-MRR decreased social interest without influencing aggression and with an increase in social discrimination. Additionally, inhibition of the same cells increased the friendly social be-havior during social interaction test. No behavioral changes were detected in anxiety, memory and locomotion. All in all, dopaminergic cells were present both in the mice and human MRR, and manipulation of dopaminergic neurons of the MRR elicited a specific social response.

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“…Despite each condition having a different etiology, most of these disorders are characterized by abnormal social behavior. Moreover, in some cases (especially in Parkinson's disease and schizophrenia), the major target of presently available therapies is the dopaminergic system [43][44][45].…”

Section: Introductionmentioning

confidence: 99%

The Dopaminergic Cells in the Median Raphe Region Regulate Social Behavior in Male Mice

Chaves,

Török,

Fazekas

et al. 2024

IJMS

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According to previous studies, the median raphe region (MRR) is known to contribute significantly to social behavior. Besides serotonin, there have also been reports of a small population of dopaminergic neurons in this region. Dopamine is linked to reward and locomotion, but very little is known about its role in the MRR. To address that, we first confirmed the presence of dopaminergic cells in the MRR of mice (immunohistochemistry, RT-PCR), and then also in humans (RT-PCR) using healthy donor samples to prove translational relevance. Next, we used chemogenetic technology in mice containing the Cre enzyme under the promoter of the dopamine transporter. With the help of an adeno-associated virus, designer receptors exclusively activated by designer drugs (DREADDs) were expressed in the dopaminergic cells of the MRR to manipulate their activity. Four weeks later, we performed an extensive behavioral characterization 30 min after the injection of the artificial ligand (Clozapine-N-Oxide). Stimulation of the dopaminergic cells in the MRR decreased social interest without influencing aggression and with an increase in social discrimination. Additionally, inhibition of the same cells increased the friendly social behavior during social interaction test. No behavioral changes were detected in anxiety, memory or locomotion. All in all, dopaminergic cells were present in both the mouse and human samples from the MRR, and the manipulation of the dopaminergic neurons in the MRR elicited a specific social response.

show abstract

Dopamine, Psychosis, and Symptom Fluctuation: A Narrative Review

Cited by 5 publications

References 151 publications

Implantable Electrochemical Microsensors for In Vivo Monitoring of Animal Physiological Information

Implantable Electrochemical Microsensors for In Vivo Monitoring of Animal Physiological Information

The Role of the Dopaminergic Cells of the Median Raphe Region in the Behavior of the Male Mice

The Dopaminergic Cells in the Median Raphe Region Regulate Social Behavior in Male Mice

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