Dopamine receptor repertoire of human granulosa cells

Rey-Ares, Verónica; Lazarov, Nikolai; Berg, Dieter; Berg, U.; Kunz, Lars; Mayerhofer, Artur

doi:10.1186/1477-7827-5-40

Cited by 31 publications

(23 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2). Improved fertility was later confirmed in a trial involving 44 infertile patients due to luteal phase defects, treatment with 40 mg of a dried Vitex agnus castus (VAC BNO 1095) preparation increased both, serum progesterone and estradiol [23,24]. Following this treatment ovulatory cycles were present in 93% and fertility rate was restored in 71.4% of the patients.…”

Section: Mastodynia and Fertilitymentioning

confidence: 73%

The premenstrual syndrome, premenstrual mastodynia, fibrocystic mastopathy and infertility have often common roots: effects of extracts of chasteberry (Vitex agnus castus) as a solution

Seidlová-Wuttke¹,

Wuttke²

2017

Clin Phytosci

View full text Add to dashboard Cite

The dried fruits of the chaste tree Vitex agnus castus (VAC) were traditionally used by monks as a substitute for pepper and was therefore also called Monk's pepper. For the last 50 years it is commercially provided for the treatment of premenstrual symptoms, particularly to prevent premenstrual mastodynia (mastalgia). Most studies were performed with the preparation containing an aqueous/ethanolic ectract BNO 1095. A number of placebo controlled studies gave proof that extracts of VAC had beneficial effects on premenstrual breast pain. This breast sensation is induced by latent hyperprolactinemia which is characterized by secretory episodes of prolactin release by the pituitary in response to stress and deep sleep phases. This latent hyperprolactinemia induces also often a corpus luteum insufficiency which is a common reason for infertilty. It is well accepted that prolactin release can be reduced by dopamine and dopaminergic drugs. The efficacy of VAC extracts to ameliorate prolactin induced premenstrual mastodynia was therefore suggestive that VAC may contain dopaminergic compounds. Indeed, a number of diterpenes were identified that bound to recombinant Dopamine receptors of the 2 subtype (D2 receptors) which are present in pituitary lactotropes and which mediate the inhibitory effects of dopamine and dopaminergic drugs on pituitary prolactin release. Consequently, prolactin release in vitro from dispersed pituitary cells and in vivo in rats and postmenopausal women was inhibited by VAC 1095. Placebo controlled studies proved also the efficacy of VAC extracts to ameliorate premenstrual symptoms. In several placebo-controlled studies a clear relation between reduction of breast pain and reduction of serum prolactin levels could be established. In addition VAC extracts was also highly effective in women suffering from fibrocystic mastopathy. In many of these women serum prolactin levels were also elevated and reduced by VAC extracts. The results from all trials suggested that VAC extracts ameliorated premenstrual symptoms including mastodynia, premenstrual dysphoric disorder and latent hyperprolactinemia. Cystic mastopathy and sterility due to corpus luteum insufficiencies were also beneficially influenced. Adverse events with VAC were mild and generally infrequent.

show abstract

Section: Mastodynia and Fertilitymentioning

confidence: 73%

The premenstrual syndrome, premenstrual mastodynia, fibrocystic mastopathy and infertility have often common roots: effects of extracts of chasteberry (Vitex agnus castus) as a solution

Seidlová-Wuttke¹,

Wuttke²

2017

Clin Phytosci

View full text Add to dashboard Cite

show abstract

“…Cell Viability Assay-Cell viability was estimated by measuring ATP content, which correlates with cell number and/or viability (54,55). For the ATP assay, cells were cultured on 24-well plates (Nunc GmbH & Co. KG) and treated with/without 1000 ng/ml tryptase, 1000 ng/ml heat-inactivated tryptase (15 min at 95°C), or 100 M SLIGKV for 24 h. For the reaction, 100 l of media plus 100 l of CellTiter-Glo reagent (Promega, Mannheim, Germany) were added.…”

Section: Methodsmentioning

confidence: 99%

Human Tryptase Cleaves Pro-Nerve Growth Factor (Pro-NGF)

Spinnler

Fröhlich

Arnold

et al. 2011

Journal of Biological Chemistry

Self Cite

View full text Add to dashboard Cite

“…In vitro, the stimulation of human granulosa cells with hCG did not increase mRNA or protein levels of DA receptors. D1 and D2 receptors are also present in the ovaries of rats (Rey-Ares et al, 2007).…”

Section: Dopaminementioning

confidence: 95%