Dopamine receptor subtypes modulate olfactory bulb γ-aminobutyric acid type A receptors

Brünig, Ina; Sommer, Michael J.; Hatt, Hanns; Bormann, Joachim

doi:10.1073/pnas.96.5.2456

Cited by 73 publications

(53 citation statements)

References 38 publications

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“…In mitral cells, VGCC and I A contribute to glutamate release (Lledo and Lagier, 2006), but whether they constitute potential effectors of sst2 receptors remains to be tested. Alternatively, the decreased inhibition on mitral cells after sst2 receptor activation could originate from a postsynaptic control of granule-to-mitral inhibitory transmission, as observed for dopamine (Brünig et al, 1999). In this latter study, a delayed and gradual upmodulation of GABA A receptors occurred in mitral cells after D 2 receptor activation through PKC-induced phosphorylation.…”

Section: Delayed and Long-lasting Effects On Gamma Oscillations And Dmentioning

confidence: 60%

Somatostatin Contributes toIn VivoGamma Oscillation Modulation and Odor Discrimination in the Olfactory Bulb

Lepousez

Mouret²,

Loudes³

et al. 2010

J. Neurosci.

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Neuropeptides are systematically encountered in local interneurons, but their functional contribution in neural networks is poorly documented. In the mouse main olfactory bulb (MOB), somatostatin is mainly concentrated in local GABAergic interneurons restricted to the external plexiform layer (EPL). Immunohistochemical experiments revealed that the sst2 receptor, the major somatostatin receptor subtype in the telencephalon, is expressed by mitral cells, the MOB principal cells. As odor-activated mitral cells synchronize and generate gamma oscillations of the local field potentials, we investigated whether pharmacological manipulations of sst2 receptors could influence these oscillations in freely behaving mice. In wild-type, but not in sst2 knock-out mice, gamma oscillation power decreased lastingly after intrabulbar injection of an sst2-selective antagonist (BIM-23627), while sst2-selective agonists (octreotide and L-779976) durably increased it. Sst2-mediated oscillation changes were correlated with modifications of the dendrodendritic synaptic transmission between mitral and granule cells. Finally, bilateral injections of BIM-23627 and octreotide respectively decreased and increased odor discrimination performances. Together, these results suggest that endogenous somatostatin, presumably released from EPL interneurons, affects gamma oscillations through the dendrodendritic reciprocal synapse and contributes to olfactory processing. This provides the first direct correlation between synaptic, oscillatory, and perceptual effects induced by an intrinsic neuromodulator.

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Section: Delayed and Long-lasting Effects On Gamma Oscillations And Dmentioning

confidence: 60%

Somatostatin Contributes toIn VivoGamma Oscillation Modulation and Odor Discrimination in the Olfactory Bulb

Lepousez

Mouret²,

Loudes³

et al. 2010

J. Neurosci.

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“…These results further raise the possibility that DA-INs mediate both excitatory and inhibitory interactions between principal neurons via different mechanisms. In addition, DA may modulate interneurons or synapses that we have not specifically investigated (Brünig et al, 1999;Davila et al, 2003). Future studies focusing on D 1 -like receptors are therefore likely to reveal additional effects of DA.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, DA can modulate synaptic transmission between MCs and interneurons (Brünig et al, 1999;Davila et al, 2003). However, it remains unclear how DA is released from interneurons and transmitted to its targets, and how it modulates information processing in the OB.…”

Section: Introductionmentioning

confidence: 99%

Dopaminergic Modulation of Mitral Cells and Odor Responses in the Zebrafish Olfactory Bulb

Bundschuh

Zhu²,

Schärer³

et al. 2012

J. Neurosci.

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In the olfactory bulb, the modulatory neurotransmitter dopamine (DA) is coexpressed with GABA by local interneurons, but its role in odor processing remains obscure. We examined functions of DA mediated by D 2 -like receptors in the olfactory bulb of adult zebrafish by pharmacology, whole-cell recordings, calcium imaging, and optogenetics. Bath application of DA had no detectable effect on odorantevoked sensory input. DA directly hyperpolarized mitral cells (

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“…GABA A R and dopamine receptor D5 (DRD5) can be coimmunoprecipitated from mammalian brain samples, which indicates a direct physical association between GABA A R and DRD5; however, no direct physical association was detected between GABA A R and DRD1 (Liu et al, 2000). According to a whole-cell patch-clamp recording study using olfactory bulb neurons (Brünig et al, 1999) and striatum (Goffin et al, 2010), suppression of GABA A R results in activation of DRD1, which indicates functional collaboration between these two receptors.…”

Section: Developmental Organization Of the Gabaergic Systemmentioning

confidence: 99%

Development of the γ-amino butyric acid (GABA)-ergic signaling system and its role in larval swimming in sea urchin

Katow

Abe

Katow

et al. 2013

Journal of Experimental Biology

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SUMMARYThe present study aimed to elucidate the development and γ-amino butyric acid (GABA)-ergic regulation of larval swimming in the sea urchin Hemicentrotus pulcherrimus by cloning glutamate decarboxylase (Hp-gad), GABA A receptor (Hp-gabrA) and GABA A receptor-associated protein (Hp-gabarap), and by performing immunohistochemistry. The regulation of larval swimming was increasingly dependent on the GABAergic system, which was active from the 2days post-fertilization (d.p.f.) pluteus stage onwards. GABA-immunoreactive cells were detected as a subpopulation of secondary mesenchyme cells during gastrulation and eventually constituted the ciliary band and a subpopulation of blastocoelar cells during the pluteus stage. Hp-gad transcription was detected by RT-PCR during the period when Hp-Gad-positive cells were seen as a subpopulation of blastocoelar cells and on the apical side of the ciliary band from the 2d.p.f. pluteus stage. Consistent with these observations, inhibition of GAD with 3-mercaptopropioninc acid inhibited GABA immunoreactivity and larval swimming dose dependently. Hp-gabrA amplimers were detected weakly in unfertilized eggs and 4d.p.f. plutei but strongly from fertilized eggs to 2d.p.f. plutei, and Hp-GabrA, together with GABA, was localized at the ciliary band in association with dopamine receptor D1 from the two-arm pluteus stage. Hpgabarap transcription and protein expression were detected from the swimming blastula stage. Inhibition of the GABA A receptor by bicuculline inhibited larval swimming dose dependently. Inhibition of larval swimming by either 3-mercaptopropionic acid or bicuculline was more severe in older larvae (17 and 34d.p.f. plutei) than in younger ones (1d.p.f. prism larvae).

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Dopamine receptor subtypes modulate olfactory bulb γ-aminobutyric acid type A receptors

Cited by 73 publications

References 38 publications

Somatostatin Contributes toIn VivoGamma Oscillation Modulation and Odor Discrimination in the Olfactory Bulb

Somatostatin Contributes toIn VivoGamma Oscillation Modulation and Odor Discrimination in the Olfactory Bulb

Dopaminergic Modulation of Mitral Cells and Odor Responses in the Zebrafish Olfactory Bulb

Development of the γ-amino butyric acid (GABA)-ergic signaling system and its role in larval swimming in sea urchin

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