Dopamine receptors in human basilar arteries

Förster, Christine; Drew, G. M.; Hilditch, A.; Whalley, Eric T.

doi:10.1016/0014-2999(83)90332-1

Cited by 33 publications

(20 citation statements)

References 19 publications

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“…Direct ef fects of dopamine and dopaminergic agonists have provoked speculation ranging from their causal in volvement in cerebrovascular pathology (Wurtman and Zervas, 1974;White et aI. , 1976) to providing a potential therapeutic avenue in similar conditions (Boullin et aI., 1977;Forster and Whalley, 1981). In addition, the influence of the intracerebral dopa minergic systems on CBF remains to be clearly established, for, although stereotaxic lesions of dopaminergic systems have little effect on basal levels of blood flow or the response to induced hypercapnia (Dahlgren, 1981), lesions of dopamin ergic systems may modify the cerebral circulatory response to amphetamine without disturbing glu cose utilization (Lindvall et aI., 1981).…”

Section: Discussion Dopaminergic Influences On Cerebral Tissue Perfusionmentioning

confidence: 99%

Effect of Apomorphine on the Relationship between Local Cerebral Glucose Utilization and Local Cerebral Blood Flow (with an Appendix on its Statistical Analysis)

McCulloch

Kelly

Ford

1982

J Cereb Blood Flow Metab

124

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Summary:The alterations in local glucose utilization and local blood flow in 36 discrete regions of the central nervous system (CNS) that occur following the intravenous administration of the putative dopaminergic agonist, apomor phine (0,5 mg/kg), have been measured using the quantitative autoradiographic 14C-2-deoxyglucose and 14C-iodoantipyrine techniques, In eight of the regions examined (frontal and sensory-motor cortices, ventral thalamus, caudate nu cleus, globus pallidus, substantia nigra, subthalamic nucleus, and posterior cerebellar hemisphere), significant elevations of local cerebral blood flow (CBF) were observed following apomorphine administration. In these eight regions, proportionately similar, significant elevations in local glucose utiliza tion were observed following apomorphine. In two of the regions investigated (anterior cingulate cortex and lateral habenular nucleus), significant reductions in both local blood flow and glucose utilization were observed following apomorphine administration. In the majority of regions examined (26 of the total 36), apomorphine did not alter significantly either blood flow or glucose use. Using a statistical approach, described in detail in an appendix, the re lationship between local rates of glucose utilization and local levels of tissue blood flow was analyzed. A relationship between local CBF and local glucose utilization was found following apomorphine, and the nature of this relation ship was indistinguishable from that observed in control animals. In no region of the CNS was a significant deviation from the normal CBF -glucose use relationship demonstrated following apomorphine administration. These re sults point to the greater importance of the effects of apomorphine upon tissue metabolic activity, rather than its direct vascular action, as being the major mechanism underlying the observed alterations in local CBF. The statistical methods provide a rigorous analytical approach to the analysis of alterations in the relationship, both locally and globally, of blood supply to glucose utiliza tion.

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Section: Discussion Dopaminergic Influences On Cerebral Tissue Perfusionmentioning

confidence: 99%

Effect of Apomorphine on the Relationship between Local Cerebral Glucose Utilization and Local Cerebral Blood Flow (with an Appendix on its Statistical Analysis)

McCulloch

Kelly

Ford

1982

J Cereb Blood Flow Metab

124

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“…6). (11)(12)(13)(14)(15)(16). Hence, it is not likely that nigral-induced decrease in striatal blood flow in the present experiment is due to a direct effect of dopamine because phentolamine did not affect this decrease.…”

Section: Methodsmentioning

confidence: 70%

Nigral-Induced Decrease in Striatal Blood Flow and the Influence on This Decrease of Several Drugs in Reserpinized and Non-Reserpinized Cats

Yanagihashi

1986

Japanese Journal of Pharmacology

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Abstract-The effect of nigral electrical stimulation on regional blood flow in the caudate nucleus and the cerebral cortex, and the influence of several drugs on these effects were examined in reserpinized or non-reserpinized cats. A double thermistor element was inserted into the left caudate nucleus, and a plate-type thermocouple element was put on the left cerebral cortex. The left substantia nigra was electrically stimulated for 10 sec through a concentric bipolar electrode with a diameter of 0.3 mm (30 Hz, 1 msec, 10-30 V). In non-reserpinized cats, the nigral stimulation caused a decrease in striatal blood flow, increase in cortical blood flow and rise in mean blood pressure. Hexamethonium (3 mg/kg, i.v.) blocked completely the rise in mean blood pressure following nigral stimulation, but did not affect a decrease in striatal blood flow, indicating that a decrease in striatal blood flow following nigral stimulation was not due to the activation of the peripheral sympathetic nervous system. Nigral-induced decrease in striatal blood flow in non-reserpinized cats was blocked by haloperidol (0.1 mg/kg, i.v.), methysergide (1 mg/kg, i.v.) and reserpine (2 mg/kg, i.v.), but not by phentolamine (7 mg/kg, i.v.). In reserpinized cats, nigral stimulation caused an increase in striatal blood flow in contrast to a decrease in non-reserpinized cats. After administration of 5-HTP (50 mg/kg, i.v.) in reserpinized cats, nigral stimulation decreased the striatal blood flow. On the other hand, after administration of L-DOPA (30 mg/kg, i.v.) in reserpinized cats, nigral stimulation increased striatal blood flow. These results suggest that a decrease in striatal blood flow following nigral stimulation is due to the activation of a serotonergic mechanism mediated by dopaminergic neurons.

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“…Using molecular biology techniques peripheral dopamine receptors have been identified outside the CNS, e.g. in the heart, basilar artery, portal vein, cornea of the eye, and in lymphocytes [9,20,21,[32][33][34]. Dopamine receptor subtypes have also been detected in the kidney, ureter and urinary bladder [16][17][18][19]35].…”

Section: Discussionmentioning

confidence: 99%

Localization of peripheral dopamine D1 and D2 receptors in rat corpus cavernosum

et al. 2002

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Objective To detect and locate anatomically peripheral dopamine D1 and D2 receptors in rat cavernosa, as dopamine is important in sexual drive and penile erection through receptors located in the central nervous system. Materials and methods Corpora cavernosa were obtained from Sprague-Dawley rats; total RNA and membrane proteins were extracted and cryostat sections prepared. The rat brain hypothalamus was used as a control for dopamine D1 and D2 receptors. The presence and expression of peripheral dopamine D1 and D2 receptor mRNAs in rat corpus cavernosa was assessed using reverse transcription and polymerase chain reaction (RT-PCR), and Northern blot hybridization using 32 P-UTP-labelled RNA probes. Concurrently, corresponding proteins from D1 and D2 receptors were assayed and detected by a Western blotting technique. The anatomical location of dopamine D1 and D2 receptor mRNAs in rat penile tissues was identified by in situ hybridization using 35 S-UTP-labelled RNA probes in cryostat sections.Immunohistochemical staining was used to locate peripheral dopamine D1 and D2 receptor proteins in rat corpora cavernosa. Results Dopamine D1 and D2 receptor gene expression was detected in rat corpora cavernosa. In situ hybridization signals for dopamine D1 and D2 receptor mRNAs were localized to corpus cavernosal tissues and dorsal vessels in the rat penis. Western blot analyses showed peripheral dopamine D1 and D2 receptor proteins in rat corpora cavernosa. Immunohistochemically, peripheral dopamine D1 and D2 receptor proteins were detected in dorsal nerves, dorsal vessels and corpus cavernosal smooth muscle of the rat penile tissues. Conclusions Peripheral dopamine D1 and D2 receptors are present in the corpora cavernosa of rats. The functional significance of these receptors and signal transduction pathways in modulating the vascular tone of the penis warrants further investigation.

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Dopamine receptors in human basilar arteries

Cited by 33 publications

References 19 publications

Effect of Apomorphine on the Relationship between Local Cerebral Glucose Utilization and Local Cerebral Blood Flow (with an Appendix on its Statistical Analysis)

Effect of Apomorphine on the Relationship between Local Cerebral Glucose Utilization and Local Cerebral Blood Flow (with an Appendix on its Statistical Analysis)

Nigral-Induced Decrease in Striatal Blood Flow and the Influence on This Decrease of Several Drugs in Reserpinized and Non-Reserpinized Cats

Localization of peripheral dopamine D1 and D2 receptors in rat corpus cavernosum

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