Dopamine Regulation of GABAA Receptors Contributes to Light/Dark Modulation of the ON-Cone Bipolar Cell Receptive Field Surround in the Retina

Chaffiol, Antoine; Ishii, Masaaki; Cao, Yu; Mangel, Stuart C.

doi:10.1016/j.cub.2017.07.063

Cited by 29 publications

(35 citation statements)

References 62 publications

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“…For example, dopamine and dopamine antagonists are known to alter the balance between the center and surround components of center-surround antagonistic receptive fields of retinal neurons by altering the degree of electrical coupling between cells 61 – 65 . This role has been demonstrated in rabbit on-bipolar cells whereby dopamine concentration was increased in photopic conditions, leading to an increase in the weighting of the off-surround, whereas maintained darkness and/or blocking dopamine receptors led to diminished receptive field surrounds 66 . Looking specifically at RGCs, Jensen and Daw 67 found dopamine antagonists to cause a reduction in the antagonistic surround input to the off-center RGC receptive field, leading to a shift in the center-surround arrangement in favour of the center (i.e., larger central receptive field size).…”

Section: Discussionmentioning

confidence: 79%

Altered spatial summation optimizes visual function in axial myopia

Stapley

Anderson

Saunders

et al. 2020

Sci Rep

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This study demonstrates significant differences between the area of complete spatial summation (Ricco's area, RA) in eyes with and without non-pathological, axial myopia. Contrast thresholds were measured for six stimuli (0.01-2.07 deg 2) presented at 10º eccentricity in 24 myopic subjects and 20 age-similar non-myopic controls, with RA estimated using iterative two-phase regression analysis. To explore the effects of axial length-induced variations in retinal image size (RIS) on the measurement of RA, refractive error was separately corrected with (i) trial lenses at the anterior focal point (near constant inter-participant RIS in mm), and (ii) contact lenses (RIS changed with axial length). For spectacle corrected measurements, RA was significantly larger in the myopic group, with a significant positive correlation also being observed between RA and measures of co-localised peripheral ocular length. With contact lens correction, there was no significant difference in RA between the groups and no relationship with peripheral ocular length. The results suggest RA changes with axial elongation in myopia to compensate for reduced retinal ganglion cell density. furthermore, as these changes are only observed when axial length induced variations in RIS are accounted for, they may reflect a functional adaptation of the axially-myopic visual system to an enlarged RIS. Myopia is a common refractive condition, whereby the axial length of the globe is too great for its optical power. Whilst the optical refractive error of myopia can be corrected using spectacles or contact lenses, the axial elongation of the myopic eye can markedly increase the risk of sight-threatening conditions such as retinal detachment 1 , glaucoma 2 , and myopic macular degeneration 3. In the absence of such pathological processes it has also been demonstrated that the globe elongation that occurs in myopia can lead to secondary peripheral retinal thinning 4-6 , in addition to a reduction in the density of both photoreceptors 7-9 and retinal ganglion cells (RGCs) 10,11. Deficits in visual function have also been reported in the myopic, but otherwise healthy, visual system. Numerous studies have objectively investigated retinal function in myopia through measurement of standard electroretinograms (ERG) 12,13 pattern ERG 14 and multifocal ERG 4,13,15. These studies have revealed altered responses in myopes, including reductions in amplitude 12-14 and longer implicit times 4,13,15. Other studies have reported reductions in function when examined using clinical tests of visual acuity 16,17 , peripheral resolution acuity 4,18,19 , and contrast sensitivity 20. It may be hypothesized that changes in visual function observed in non-pathological myopia may be accounted for by reductions in the local density of retinal neurons (e.g., RGCs) and corresponding alterations in the basic visual process of spatial summation. This refers to the ability of visual system to integrate light energy over area and serves to maximize the detection of a signal in the presenc...

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Section: Discussionmentioning

confidence: 79%

Altered spatial summation optimizes visual function in axial myopia

Stapley

Anderson

Saunders

et al. 2020

Sci Rep

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“…Dopamine furthermore modulates horizontal cells and subsets of RGCs via D 1 R inhibition of voltage-gated Ca 2+ or Na + currents to decrease visual signaling (Jensen and Daw, 1986 ; Vaquero et al, 2001 ; Hayashida and Ishida, 2004 ; Hayashida et al, 2009 ; Blasic et al, 2012 ; Ogata et al, 2012 ; Liu et al, 2016b ). Lastly, previous studies have shown that light-adaptation or activation of D 1 Rs in bipolar cells leads to increased GABAergic feedback from horizontal cells, increasing the strength of surround inhibition (Cook and McReynolds, 1998 ; Chaffiol et al, 2017 ). Taken together, dopamine mediates light adaptation in retinal cell populations through gap junction regulation and by controlling neuronal response gain control.…”

Section: Discussionmentioning

confidence: 92%

Dopaminergic Modulation of Signal Processing in a Subset of Retinal Bipolar Cells

Hellmer

Bohl

Hall

et al. 2020

Front. Cell. Neurosci.

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The retina and the olfactory bulb are the gateways to the visual and olfactory systems, respectively, similarly using neural networks to initiate sensory signal processing. Sensory receptors receive signals that are transmitted to neural networks before projecting to primary cortices. These networks filter sensory signals based on their unique features and adjust their sensitivities by gain control systems. Interestingly, dopamine modulates sensory signal transduction in both systems. In the retina, dopamine adjusts the retinal network for daylight conditions ("light adaptation"). In the olfactory system, dopamine mediates lateral inhibition between the glomeruli, resulting in odorant signal decorrelation and discrimination. While dopamine is essential for signal discrimination in the olfactory system, it is not understood whether dopamine has similar roles in visual signal processing in the retina. To elucidate dopaminergic effects on visual processing, we conducted patch-clamp recording from second-order retinal bipolar cells, which exhibit multiple types that can convey different temporal features of light. We recorded excitatory postsynaptic potentials (EPSPs) evoked by various frequencies of sinusoidal light in the absence and presence of a dopamine receptor 1 (D 1 R) agonist or antagonist. Application of a D 1 R agonist, SKF-38393, shifted the peak temporal responses toward higher frequencies in a subset of bipolar cells. In contrast, a D 1 R antagonist, SCH-23390, reversed the effects of SKF on these types of bipolar cells. To examine the mechanism of dopaminergic modulation, we recorded voltage-gated currents, hyperpolarizationactivated cyclic nucleotide-gated (HCN) channels, and low-voltage activated (LVA) Ca 2+ channels. SKF modulated HCN and LVA currents, suggesting that these channels are the target of D 1 R signaling to modulate visual signaling in these bipolar cells. Taken together, we found that dopamine modulates the temporal tuning of a subset of retinal bipolar cells. Consequently, we determined that dopamine plays a role in visual signal processing, which is similar to its role in signal decorrelation in the olfactory bulb.

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“…Under conditions that affect the central nervous system, such as SCZ and smoking, both the M- and P-pathways may exhibit dysfunction because of an imbalance of neurotransmitters ( Kéri et al, 2002 ; Chen et al, 2003 ; Govind et al, 2009 ). For example, dopaminergic hypofunction that is caused by an imbalance of cortical upregulation may increase functional antagonism between the center and periphery of the receptive field of bipolar cells ( Chaffiol et al, 2017 ; Nakao et al, 2018 ). The reverse may also be true, in which dopamine hyperfunction may decrease receptive fields of bipolar cells.…”

Section: Discussionmentioning

confidence: 99%

Tobacco Use Decreases Visual Sensitivity in Schizophrenia

et al. 2018

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Smoking prevalence in patients who are diagnosed with schizophrenia (SCZ) is higher than in the general population. Chronic tobacco use in SCZ patients may reduce the side effects of antipsychotic drugs, thus serving as a self-medication for such side effects. Understanding the ways in which chronic tobacco use influences visual sensitivity has clinical implications, which may serve as a tool for non-invasively diagnosing early-stage visual processing deficits. The present study evaluated the effects of chronic tobacco use on visual sensitivity in SCZ patients. Our purpose was to provide new directions for future research, mainly psychophysical and electrophysiological studies. In the present study, 40 smoker controls (SC), 20 SCZ tobacco users, and 20 SCZ tobacco nonusers were recruited from the Psychosocial Care Center. Visual sensitivity was compared between both SCZ groups and the SC group. Patients with SCZ who were chronic tobacco users presented lower visual sensitivity for chromatic (p < 0.001) and achromatic (p < 0.001) stimuli compared with the other groups. Our findings highlight the need to evaluate possible addictive behavior in patients with SCZ, which may contribute to public policies that seek to improve the quality of life of SCZ patients and their families.

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Dopamine Regulation of GABAA Receptors Contributes to Light/Dark Modulation of the ON-Cone Bipolar Cell Receptive Field Surround in the Retina

Cited by 29 publications

References 62 publications

Altered spatial summation optimizes visual function in axial myopia

Altered spatial summation optimizes visual function in axial myopia

Dopaminergic Modulation of Signal Processing in a Subset of Retinal Bipolar Cells

Tobacco Use Decreases Visual Sensitivity in Schizophrenia

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