2000
DOI: 10.1016/s0006-8993(00)02403-3
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Dopamine release from pharmacologically distinct storage pools in rat striatum following stimulation at frequency of neuronal bursting

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Cited by 53 publications
(73 citation statements)
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References 23 publications
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“…Recent work has suggested that dopamine release dynamically adapts in response to spike activity (Garris et al, 1999;Yavich and MacDonald, 2000), and that regionally specific increases DA signaling may be due to multiple factors such as innervation and autoreceptor density, efficiency of dopamine reuptake, as well as afferent neuronal activity (Montague et al, 2004). For example, the kinetics of dopamine release and uptake suggest that the medial prefrontal cortex and the amygdala show a greater synaptic overflow per spike and are termed 'release dominated' due to sparse uptake as compared to the striatum, which is 'uptake dominated' due to denser perisynaptic uptake systems (Garris et al, 1993;Garris and Wightman, 1994).…”
Section: Discussionmentioning
confidence: 99%
“…Recent work has suggested that dopamine release dynamically adapts in response to spike activity (Garris et al, 1999;Yavich and MacDonald, 2000), and that regionally specific increases DA signaling may be due to multiple factors such as innervation and autoreceptor density, efficiency of dopamine reuptake, as well as afferent neuronal activity (Montague et al, 2004). For example, the kinetics of dopamine release and uptake suggest that the medial prefrontal cortex and the amygdala show a greater synaptic overflow per spike and are termed 'release dominated' due to sparse uptake as compared to the striatum, which is 'uptake dominated' due to denser perisynaptic uptake systems (Garris et al, 1993;Garris and Wightman, 1994).…”
Section: Discussionmentioning
confidence: 99%
“…First, the dose of PCBs used in this study is considerably smaller than that used in other studies that have demonstrated reductions in brain DA concentrations in adult rats exposed to PCBs . Second, the lack of discernible effect of PCBs on tissue DA concentrations may in part be because of the existence of two pools of DA-a readily releasable pool (RRP) of DA replenished by de novo synthesis and a larger, non-readily releasable storage pool (Chiueh and Moore 1975;Kuczenski 1977;Yavich and MacDonald 2000) [estimates of the size of the RRP of DA vary between 5% and 20% of total DA (Javoy and Glowinski 1971;Yavich 1996)]. Because tissue DA includes contributions from both pools while extraneuronal DA reflects changes in only the RRP of DA, the consequences of PCB exposure would be more apparent in the smaller pool.…”
Section: Discussionmentioning
confidence: 99%
“…How is this phasic change in firing activity translated into DA release at target structures? Experimental data has shown that a single-pulse stimulation applied to the VTA or the median forebrain bundle leads to a DA release lasting a few seconds (Kilpatrick et al 2000;Fields et al 2007;Phillips et al 2003;Robinson et al 2002;Roitman et al 2004;Yavich and MacDonald 2000). The probability of release of DA is however lower than that of glutamate and is varies greatly among DA synapses (Daniel et al 2009).…”
Section: (T)mentioning
confidence: 99%