Dopamine transporter availability in symptomatic depressed patients with seasonal affective disorder and healthy controls

Neumeister, Alexander; Willeit, Matthäus; Praschak-Rieder, Nicole; Asenbaum, S.; Stastny, J.; Hilger, Eva; Pirker, Walter; Konstantinidis, Anastasios; Kasper, Siegfried

doi:10.1017/s003329170105434z

Cited by 95 publications

(49 citation statements)

References 30 publications

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“…Lower striatal DAT levels have also been observed in people with ADHD (Fusar-Poli et al, 2012) and seasonal affective disorder (Neumeister et al, 2001). People with ADHD also exhibit increased risky choices in the IGT (Mantyla et al, 2012), albeit to a lesser extent when compared with BD (Ibanez et al, 2012).…”

Section: Discussionmentioning

confidence: 95%

Reduced Dopamine Transporter Functioning Induces High-Reward Risk-Preference Consistent with Bipolar Disorder

Enkhuizen

Henry

Minassian

et al. 2014

Neuropsychopharmacol

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Individuals with bipolar disorder (BD) exhibit deleterious decision making, negatively impacting their lives. Such aberrant decision making can be quantified using the Iowa Gambling Task (IGT), which requires choosing between advantageous and disadvantageous options based on different reward/punishment schedules. The mechanisms underlying this behavioral deficit are unknown, but may include the reduced dopamine transporter (DAT) functioning reported in BD patients. Using both human and mouse IGTs, we tested whether reduced DAT functioning would recreate patterns of deficient decision making of BD patients. We assessed the IGT performance of 16 BD subjects (7 female) and 17 healthy control (HC) subjects (12 female). We recorded standard IGT performance measures and novel post-reward and post-punishment decision-making strategies. We characterized a novel single-session mouse IGT using C57BL/6J mice (n ¼ 44). The BD and HC IGT performances were compared with the effects of chronic (genetic knockdown (KD; n ¼ 31) and wild-type (n ¼ 28) mice) and acute (C57BL/6J mice (n ¼ 89) treated with the DAT inhibitor GBR12909) reductions of DAT functioning in mice performing this novel IGT. BD patients exhibited impaired decision making compared with HC subjects. Both the good-performing DAT KD and GBR12909-treated mice exhibited poor decision making in the mouse IGT. The deficit of each population was driven by highreward sensitivity. The single-session mouse IGT measures dynamic risk-based decision making similar to humans. Chronic and acute reductions of DAT functioning in mice impaired decision-making consistent with poor IGT performance of BD patients. Hyperdopaminergia caused by reduced DAT may impact poor decision making in BD patients, which should be confirmed in future studies.

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Section: Discussionmentioning

confidence: 95%

Reduced Dopamine Transporter Functioning Induces High-Reward Risk-Preference Consistent with Bipolar Disorder

Enkhuizen

Henry

Minassian

et al. 2014

Neuropsychopharmacol

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“…Thus, the specificity of the changes remain an issue. In addition, besides involvement of the serotonergic system, abnormal neurotrophin signaling [4], aberrant expression of inflammatory cytokines [126,127], and the dopaminergic system [128][129][130] are thought to contribute to the genesis of depression as well. Therefore, the occurrence and development of the disorder is a complex process involving multiple mechanisms.…”

Section: Pet and Spect Imaging Of Neurotransmittersmentioning

confidence: 99%

Molecular, Functional, and Structural Imaging of Major Depressive Disorder

Zhang

Zhu

et al. 2016

Neurosci. Bull.

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Major depressive disorder (MDD) is a significant cause of morbidity and mortality worldwide, correlating with genetic susceptibility and environmental risk factors. Molecular, functional, and structural imaging approaches have been increasingly used to detect neurobiological changes, analyze neurochemical correlates, and parse pathophysiological mechanisms underlying MDD. We reviewed recent neuroimaging publications on MDD in terms of molecular, functional, and structural alterations as detected mainly by magnetic resonance imaging (MRI) and positron emission tomography. Altered structure and function of brain regions involved in the cognitive control of affective state have been demonstrated. An abnormal default mode network, as revealed by resting-state functional MRI, is likely associated with aberrant metabolic and serotonergic function revealed by radionuclide imaging. Further multi-modal investigations are essential to clarify the characteristics of the cortical network and serotonergic system associated with behavioral and genetic variations in MDD.

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“…Si une réduction de la disponibilité du transporteur de la dopamine a été observée dans la région striatale du cerveau de patients atteints du TAS comparativement à des sujets témoins, elle a seulement été décelée dans le striatum gauche [27] et, encore une fois, cette observation aurait pu être la conséquence d'une variation endogène de la disponibilité du neurotransmetteur. Comme dans le cas évoqué précédemment de la sérotonine, une diminution provoquée de la quantité de catécholamines dans le cerveau -par exemple en utilisant un inhibiteur de synthèse des catécholamines, l'alpha-méthyle-para-tyrosine (AMPT) -peut provoquer une rechute vers l'état dépressif.…”

Section: Troisième Suspect : Les Catécholaminesunclassified