Dopamine transporter gene polymorphism in children with ADHD: A pilot study in Indonesian samples

Wiguna, Tjhin; Ismail, Raden Irawati; Winarsih, Noorhana Setyawati; Kaligis, Fransiska; Hapsari, Anggia; Budiyanti, Lina; Sekartini, Rini; Rahayu, Susan; Guerrero, Anthony P. S.

doi:10.1016/j.ajp.2017.03.041

Cited by 9 publications

(5 citation statements)

References 22 publications

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“…Family-based designs are robust against population admixture and stratification, and allow conducting complex segregation analysis and linkage and association studies that would be next to impossible in case/control-based designs [32,61,62,63]. With few exceptions [64,65,66,67], recent genetic studies on ADHD have primarily focused on case/control-based designs to study genetic contributions to ADHD susceptibility [15,16,18,68,69,70].…”

Section: Discussionmentioning

confidence: 99%

Genetic Variation Underpinning ADHD Risk in a Caribbean Community

Puentes-Rozo

Acosta-López

Cervantes-Henríquez

et al. 2019

Cells

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Attention Deficit Hyperactivity Disorder (ADHD) is a highly heritable and prevalent neurodevelopmental disorder that frequently persists into adulthood. Strong evidence from genetic studies indicates that single nucleotide polymorphisms (SNPs) harboured in the ADGRL3 (LPHN3), SNAP25, FGF1, DRD4, and SLC6A2 genes are associated with ADHD. We genotyped 26 SNPs harboured in genes previously reported to be associated with ADHD and evaluated their potential association in 386 individuals belonging to 113 nuclear families from a Caribbean community in Barranquilla, Colombia, using family-based association tests. SNPs rs362990-SNAP25 (T allele; p = 2.46 × 10−4), rs2282794-FGF1 (A allele; p = 1.33 × 10−2), rs2122642-ADGRL3 (C allele, p = 3.5 × 10−2), and ADGRL3 haplotype CCC (markers rs1565902-rs10001410-rs2122642, OR = 1.74, Ppermuted = 0.021) were significantly associated with ADHD. Our results confirm the susceptibility to ADHD conferred by SNAP25, FGF1, and ADGRL3 variants in a community with a significant African American component, and provide evidence supporting the existence of specific patterns of genetic stratification underpinning the susceptibility to ADHD. Knowledge of population genetics is crucial to define risk and predict susceptibility to disease.

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Section: Discussionmentioning

confidence: 99%

Genetic Variation Underpinning ADHD Risk in a Caribbean Community

Puentes-Rozo

Acosta-López

Cervantes-Henríquez

et al. 2019

Cells

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“…Altogether, 100 articles were read fully, and 34 articles were excluded because various reasons: e.g., missing data, overlapping samples in other publications or not fulfilling the inclusion criteria (Supplementary Table S4). Finally, 61 publications were included in the meta-analysis (Supplementary Table S5 including studies characteristics, demographics and quality assessment scores), including the current study results (Cook et al 1995; Waldman et al 1998; Jiang et al 1999; Lunetta et al 2000; Swanson et al 2000; Curran et al 2001; Todd et al 2001; Maher et al 2002; Smith et al 2003; Carrasco et al 2004; Kustanovich et al 2004; Galili-Weisstub et al 2005; Bakker et al 2005; Bobb et al 2005; Feng et al 2005; Kim et al 2005, 2006; Langley et al 2005; Simsek et al 2005; Hawi et al 2005, 2010; Brookes et al 2006; Cheuk et al 2006; Hebebrand et al 2006; Lim et al 2006; Asherson et al 2007; Brüggemann et al 2007; Qian et al 2007; Genro et al 2008; Johansson et al 2008; Wang et al 2008; Banoei et al 2008; Kopeckova et al 2008; Franke et al 2008, 2010; Niederhofer et al 2008; Kereszturi et al 2008; Gizer et al 2009; Wohl et al 2008; Martinez-Levy et al 2009, 2013; Dresler et al 2010; Aparecida da Silva et al 2011; Bidwell et al 2011; Das et al 2011; El-Tarras et al 2012; Hoogman et al 2013; de Azeredo et al 2014; Shang and Gau 2014; Hasler et al 2015; Sery et al 2015; Fonseca et al 2015; Agudelo et al 2015; Gomez-Sanchez et al 2016; Onnink et al 2016; Ortega-Rojas et al 2017; Stanley et al 2017; Wiguna et al 2017; Hong et al 2018; Morgan et al 2018). The summary of OR, SE, type of study (e.g., family TDT, case–control CC etc.…”

Section: Resultsmentioning

confidence: 99%

Association study and a systematic meta-analysis of the VNTR polymorphism in the 3′-UTR of dopamine transporter gene and attention-deficit hyperactivity disorder

et al. 2019

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Attention-deficit hyperactivity disorder (ADHD) has been postulated to associate with dopaminergic dysfunction, including the dopamine transporter (DAT1). Several meta-analyses showed small but significant association between the 10-repeat allele in the DAT1 gene in 3′-untranslated region variant number tandem repeat polymorphism and child and adolescent ADHD, whereas in adult ADHD the 9-repeat allele was suggested to confer as risk allele. Interestingly, recent evidence indicated that the long-allele variants (10 repeats and longer) might confer to lower expression of the transporter in comparison to the short-allele. Therefore, we assessed here the association in samples consisting of families with child and adolescent ADHD as well as a case-control sample, using either the 10-versus 9-repeat or the long-versus short-allele approach. Following, we conducted a systematic review and meta-analysis, including family and case-control studies, using the two aforementioned approaches as well as stratifying to age and ethnicity. The first approach (10-repeat) resulted in nominal significant association in child and adolescent ADHD (OR 1.1050 p = 0.0128), that became significant stratifying to European population (OR 1.1301 p = 0.0085). The second approach (long-allele) resulted in significant association with the whole ADHD population (OR 1.1046 p = 0.0048), followed by significant association for child and adolescent ADHD (OR 1.1602 p = 0.0006) and in Caucasian and in European child and adolescent ADHD (OR 1.1310 p = 0.0114; OR 1.1661 p = 0.0061; respectively). We were not able to confirm the association reported in adults using both approaches. In conclusion, we found further indication for a possible DAT1 gene involvement; however, further studies should be conducted with stringent phenotyping to reduce heterogeneity, a limitation observed in most included studies.

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“…A study conducted by Suryani et al. (2011) in Jakarta, the capital of Indonesia, found that the proportion of children with ADHD in grades 1–6 was approximately 26% [ 4 , 5 ]. Some studies reported that executive function played an important role for all individuals, including children with ADHD [ 3 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…More than 50% of children with ADHD demonstrate significant impairment in executive function, affecting their academic achievement and ability to develop optimal decision-making skills [ 4 , 10 ]. Individuals with ADHD experience brain dysfunction in several regions, such as the fronto-cingulo-striato-thalamic and fronto-parieto-cerebellar networks, that mediate multisystem impairments of cognitive control, attention, timing, and working memory [ 5 , 11 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Developing and feasibility testing of the Indonesian computer-based game prototype for children with attention deficit/hyperactivity disorder

Wiguna

Ismail²,

Kaligis³

et al. 2021

Heliyon

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The aim of this study was to develop an Indonesian computer-based game prototype, including feasibility testing, targeted on attention deficit/hypersensitivity disorder (ADHD) clinical symptoms and executive function. The study comprised five steps. The first to third steps used an exploratory qualitative research design. The Delphi technique with FGD was applied to collect qualitative data. During the study, seven experts participated in ten FGDs. Feasibility testing was conducted as a one group pre- and post-test design that included ten children with drug-naïve ADHD without other mental or physical disorders. Feasibility data were collected before and after 20 training sessions with the Indonesian computer-based game prototype. The framework analysis was performed for qualitative data. Quantitative data were analyzed using the paired t-test, Pearson's correlation and Spearman's rank-order correlation. Outputs of the exploratory qualitative study were the Indonesian computer-based game prototype constructs and general agreements of the prototype,. The Indonesian computer-based game prototype construct comprised six components: reward-related processing, control inhibition, improved sustained attention, specific timing, increased arousal, and improved emotional regulation. After 20 sessions of training, several indicators decreased significantly, such as CATPRS-teacher rating (18.5 [5.31] vs. 12.9 [5.51], p = 0.047), BRIEF-GEC (64.80 [10.21] vs. 57.50 [7.51], p = 0.02), BRIEF-MI (66.1 [7.61] vs. 58.4 [7.56], p = 0.014), BRIEF-Initiate (66.6 [10.15] vs. 54.1 [6.49], p = 0.008), BRIEF-Working Memory (68.0 [6.89] vs. 60.9 [10.05], p = 0.02), and BRIEF-Organization of Material (60.7 [12.88] vs. 49.3 [11.79], p = 0.04). There was a low to moderate correlation between CATPRS-teacher and -parent rating and several BRIEF domains. Feasibility testing output also included the training procedure guideline. The present study indicated that the Indonesian computer-based game prototype could be used as a framework to develop a fixed computer-based game intervention for children with ADHD. However, further randomized controlled studies need to be conducted to show its effectiveness.

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Dopamine transporter gene polymorphism in children with ADHD: A pilot study in Indonesian samples

Cited by 9 publications

References 22 publications

Genetic Variation Underpinning ADHD Risk in a Caribbean Community

Genetic Variation Underpinning ADHD Risk in a Caribbean Community

Association study and a systematic meta-analysis of the VNTR polymorphism in the 3′-UTR of dopamine transporter gene and attention-deficit hyperactivity disorder

Developing and feasibility testing of the Indonesian computer-based game prototype for children with attention deficit/hyperactivity disorder

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