Dopamine treatment for severe ovarian hyperstimulation syndrome

Abstract

Seven oliguric patients with severe ovarian hyperstimulation syndrome following gonadotrophin treatment for in-vitro fertilization or gamete intra-Fallopian transfer, were treated with low doses of dopamine by peripheral infusion. Five patients were pregnant. The rationale for this therapeutic approach was to increase renal blood flow and glomerular filtration. In addition to dopamine, fluid intake was restricted to 500 ml/day and a protein and salt-rich diet was provided in order to increase serum osmolarity. Within 24-48 h from the beginning of the dopamine treatment, the syndrome started to regress in all cases. No adverse maternal or fetal effects occurred. We conclude that dopamine therapy may constitute a major advance towards the management of severe ovarian hyperstimulation syndrome.

Targeting the vascular endothelial growth factor system to prevent ovarian hyperstimulation syndrome

“…Improvements in urinary output and overall symptoms were reported in seven critically ill patients after they received an intravenous dopamine infusion (Ferraretti et al, 1992). Moreover, the administration of docarpamine (an oral dopamine prodrug) in 27 hospitalized patients gradually improved urinary output and ascites (Tsunoda et al, 2003).…”

Ovarian hyperstimulation syndrome: Aetiology, prevention and management

“…Dopamine and docarpamine have also been used in patients with OHSS with positive results [51,52]. The aim of treatment is to increase renal blood flow and glomerular filtration [53].…”

Dopamine receptor 2 activation inhibits ovarian vascular endothelial growth factor secretion in an ovarian hyperstimulation syndrome (OHSS) animal model: implications for treatment of OHSS with dopamine receptor 2 agonists

“…If tolerance of high oral doses of D2-ags becomes an issue, alternative vaginal or IV administration routes could be explored. Indeed, this latter strategy is supported by previous studies performed two decades ago (34) whereby continuous IV administration of dopamine was used to increase renal blood flow and glomerular filtration in five OHSS patients.…”