2007
DOI: 10.1016/j.neulet.2007.09.064
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Dopamine uptake inhibition is positively correlated with cocaine-induced stereotyped behavior

Abstract: The inhibition of dopamine (DA) uptake and the increase of extracellular DA with consequent activation of DA receptors in specific brain regions such as the nucleus accumbens (NAc) and dorsal striatum are an important, but may be not an exclusive mechanism for behavioral excitation induced by psychostimulants [2,5,14,15,24,25]. A typical spectrum of acute cocaineinduced arousal effects in animal models includes locomotor activation and stereotyped behavior consisting of continuous sniffing, rearing, licking an… Show more

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Cited by 16 publications
(19 citation statements)
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“…We compared the effect of optogenetic stimulation of dopamine cell bodies with consequences observed following their electrical stimulation that has been traditionally used for many years (Budygin et al, 1999; Budygin et al, 2000; Budygin et al, 2001a; Jones et al, 2006; Budygin, 2007; Oleson et al, 2008; Bass et al, 2010; Pattison et al, 2011; Pattison et al, 2012; Bass et al, 2013). As illustrated in Figure 3, tonic optogenetic (A) and electrical (B) VTA stimulation evoked significant increases in accumbal dopamine levels.…”
Section: Resultsmentioning
confidence: 99%
“…We compared the effect of optogenetic stimulation of dopamine cell bodies with consequences observed following their electrical stimulation that has been traditionally used for many years (Budygin et al, 1999; Budygin et al, 2000; Budygin et al, 2001a; Jones et al, 2006; Budygin, 2007; Oleson et al, 2008; Bass et al, 2010; Pattison et al, 2011; Pattison et al, 2012; Bass et al, 2013). As illustrated in Figure 3, tonic optogenetic (A) and electrical (B) VTA stimulation evoked significant increases in accumbal dopamine levels.…”
Section: Resultsmentioning
confidence: 99%
“…The increase in dopamine transmission with consequent activation of dopamine receptors in striatal regions is critically important for behavioral excitation (Kelly and Iversen, 1976; Budygin et al, 2000; Sabeti et al, 2002). This relationship is more evident when dopamine uptake is inhibited by psychostimulants (Kuczenski et al, 1991; Sabeti et al, 2002; Budygin, 2007). For example, the time course of cocaine-induced stereotypy strictly parallels the time course of the dopamine uptake changes (Budygin et al, 2007).…”
Section: Discussionmentioning
confidence: 98%
“…Implantation and voltammetric recordings were carried out as previously described (Budygin et al, 2000; 2007, Phillips et al, 2003). Rats were anesthetized with ketamine hydrochloride (100 mg/kg, i.p.)…”
Section: Experimental Pproceduresmentioning
confidence: 99%
See 1 more Smart Citation
“…Cocaine-induced psychomotor activation has been associated to a transient increment in DA levels in the caudate and accumbens nuclei of basal ganglia (Kuczenski and Segal 1992;Oleson et al 2009;Budygin 2007). Likewise, reduction in striatal dopamine levels, as in Parkinson's disease, result in reduced movement (Hornykiewicz 1966;Albin et al 1989).…”
Section: Discussionmentioning
confidence: 99%