Dopaminergic activity is reduced in the prefrontal cortex and increased in the nucleus accumbens of rats predisposed to develop amphetamine self-administration

Piazza, Pier Vincenzo; Rougé‐Pont, Françoise; Deminière, Jean-Marie; Kharoubi, Martine; Moal, Michel Le; Simon, H.

doi:10.1016/0006-8993(91)91452-7

Cited by 311 publications

(200 citation statements)

References 32 publications

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“…Accordingly, the administration of CRH directly into the VTA results in a timedependent decrease in prefrontal cortical dopamine metabolism with an increase in dopamine turnover in the nucleus accumbens (Kalivas et al 1987). This general pattern of dopaminergic neurotransmission has previously been associated with an enhanced vulnerability to engage in psychomotor stimulant self-adminis-tration (Piazza et al 1991;Goeders and Smith 1993). However, the effects of intra-VTA CRH are very different from those reported following the icv administration of the peptide.…”

Section: Discussionmentioning

confidence: 85%

Effects of the CRH Receptor Antagonist CP-154,526 on Intravenous Cocaine Self-administration in Rats

Goeders

Guerin

2000

Neuropsychopharmacology

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The role for corticotropin-releasing hormone (CRH) receptors in the maintenance of intravenous cocaine self-administration in rats was investigated using the centrally active, small molecule CRH1 receptor antagonist 526. In these experiments, adult male Wistar rats were allowed alternating 15-min periods of access to food reinforcement and cocaine selfadministration (0.125, 0.25 Self-administration; Rat During the past several years, research from our laboratory has focused on the potential involvement of the hypothalamic-pituitary-adrenal (HPA) axis in cocaine reinforcement. The HPA axis consists of a complex, well-regulated interaction between the brain, the anterior pituitary gland, and the adrenal cortex. The initial step in the activation of the HPA axis is the neuronally regulated secretion of the peptide corticotropin-releasing hormone (CRH) from the parvocellular division of the paraventricular nucleus (PVN) of the hypothalamus. CRH is released by the hypothalamus into the adenohypophyseal portal circulation to act on the pituitary to induce the secretion of adrenocorticotropin hormone (ACTH). ACTH diffuses through the general circulation until it reaches the adrenal glands. There it stimulates the biosynthesis of adrenocorticosteroids, most notably the glucocorticoids, cortisol (in humans) and corticosterone (in rats), which results in their secretion from the adrenal cortex.Cocaine has been reported to stimulate HPA axis activity in a manner analogous to various stressors, which indicates that this system has the potential to influence many of the neurochemical and behavioral effects of the drug. For example, the acute administration of cocaine dose-dependently increases plasma concentrations of corticosterone, ACTH, and ␤ -endorphin in rats (Moldow and Fischman 1987;Rivier and Vale 1987;Borowsky and Kuhn 1991). Cocaine also stimulates the release of ACTH and cortisol in humans (Mendelson et al. 1989;Baumann et al. 1995) and non-human primates (Sarnyai et al. 1996) by increasing the peak amplitude of secretory pulses of these hormones without altering pulse frequency, suggesting that these increases are driven by hypothalamic CRH (Mendelson et al. 1989;Teoh et al. 1994;Sarnyai et al. 1996). Cocaine-induced increases in ACTH and corticosterone in rats can be blocked by pretreatment with the CRH antagonist ␣ -helical CRF 9-41 (Sarnyai et al. 1992a), by immunoneutralization of CRH with an anti-CRH antibody (Rivier and Vale 1987;Sarnyai et al. 1992a), or by bilateral electrolytic lesions of the PVN (Rivier and Lee 1994), indicating that these increases are also mediated by the cocaine-induced release of CRH from parvocellular neurons in the PVN. Accordingly, it has been reported that cocaine administration also results in increases in hypothalamic CRH mRNA (Zhou et al. 1996;Rivier and Lee 1994) and alters CRH receptor binding measured autoradiographically in various regions of the rat brain (Goeders et al. 1990). These data suggest that the complex relationship between cocaine reinforcement and cort...

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Section: Discussionmentioning

confidence: 85%

Effects of the CRH Receptor Antagonist CP-154,526 on Intravenous Cocaine Self-administration in Rats

Goeders

Guerin

2000

Neuropsychopharmacology

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“…Neurochemical and neural gene expression differences contribute, at least in part, to the HR-LR behavioral phenotypes (Piazza et al, 1991b, Hooks et al, 1994a, Hooks et al, 1994b, Kabbaj et al, 2000, Kabbaj, 2004. For example, HR rats exhibit decreased hippocampal glucocorticoid receptor (GR) mRNA expression compared to LR rats, and local infusion of the GR receptor antagonist RU38486 into the hippocampus equalizes HR-LR behavioral differences, leading LRs to explore more and show decreased anxiety-like behavior (Kabbaj et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Prenatal stress does not alter innate novelty-seeking behavioral traits, but differentially affects individual differences in neuroendocrine stress responsivity

Clinton

Miller

Watson

et al. 2008

Psychoneuroendocrinology

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SummaryExposure to stress during prenatal or early postnatal life can dramatically impact adult behavior and neuroendocrine function. We recently began to selectively breed Sprague-Dawley rats for high (high responder, HR) and low (low responder, LR) novelty-seeking behavior, a trait that predicts a variety of differences in emotional reactivity, including differences in neuroendocrine stress response, fearand anxiety-like behavior, aggression, and propensity to self-administer drugs of abuse. We evaluated genetic-early environment interactions by exposing HR-and LR-bred animals to prenatal stress (PS) from pregnancy day 3 to 20, hypothesizing that PS exposure would differentially impact HR versus LR behavior and neuroendocrine reactivity. We evaluated novelty-induced locomotion, anxiety-like behavior, and corticosterone stress response in weanling (25-day-old) and adult HR-LR stressed and control males. Exposure to PS did not alter HR-LR differences in locomotion, but did impact anxietylike behavior, specifically in LR animals. Surprisingly, LR animals exposed to PS exhibited less anxiety than LR controls. HR rats were not affected by PS, with both stress and control groups showing low levels of anxiety. PS differentially impacted neuroendocrine stress reactivity in young versus adult HR-LR animals, leading to an exaggerated corticosterone response in LR pups compared to LR controls, while HRs pups were unaffected. In contrast, exposure to PS produced an exaggerated stress response in HR adults, compared to HR controls, while LR animals were not significantly affected. These findings highlight how genetic predisposition may shape individual's response to early life stressors, and furthermore, show that a history of early life stress may differentially impact an organism at different points in life. Future work will explore neural mechanisms which underlie the different behavioral and neuroendocrine consequences of prenatal stress in HR versus LR animals.

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“…CCK regulates mesolimbic function, strongly affecting dopamine-mediated behaviors such as behavioral responsivity to psychostimulants (Higgins et al, 1994) and stress-motivated behaviors (Rotzinger et al, 2002). In addition to serving other functions, dopamine-mediated transmission in the mesoaccumbal region has been implicated in the encoding of novel events (Horvitz, 2000), adaptative processing to cope with changing environmental demands (Le , and novelty-seeking behavior (Piazza et al, 1991;. Although the grade of novelty or familiarity with contextdependent experimental conditions influences the manner CCK mediates dopamine-mediated behaviors (Ladurelle et al, 1995;Hökfelt et al, 2002), only one study gives support to a correlation between the expression of the CCK gene in the tegmental ventral area and noveltyseeking behavior (Lucas et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

The CCK-system underpins novelty-seeking behavior in the rat: Gene expression and pharmacological analyses

2008

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Cholecystokinin (CCK) and its receptor CCK-2R have been shown to promote emotional responsivity and behavioral sensitization to psychostimulants in the rat. An animal model has been developed based on locomotor response to a novel inescapable environment. Animals exhibiting consistent differences in locomotor response to novelty have been termed as High and Low Responder rats (HR and LR respectively). This paradigm is deemed to model sensation-seeking, a personality trait closely associated with substance abuse. The present study provides genetic and pharmacological evidence that the CCK-ergic system modulates this behavior. Distinctive patterns of CCK-related gene expression in HR and LR animals occurred beyond the mesolimbic pathways. CCK gene expression was higher in hippocampus, amygdala, and prefrontal cortex, but lower in the ventral tegmental area of HR relative to LR rats. Levels of CCK-2R mRNA were more elevated in LR animals in some areas of the forebrain such as the prefrontal cortex, nucleus accumbens, and hippocampus. Additionally, CCK-2R blockade with the antagonist LY225.910 (0.5 mg/Kg) removed phenotype differences in sustained exploration of novel stimuli (i.e., a novel-object) in HR and LR rats exposed to an enriched open-field test series. Finally, CCK-2R blockade also altered M 2 and 5-HT 7 receptor gene expression in the mediodorsal thalamus (a strategic structure for corticothalamic trafficking) in a phenotype-dependent manner. Taken together, the findings reported here suggest that distinct CCK-ergic function may contribute to promoting individual differences in noveltyseeking behavior.

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Dopaminergic activity is reduced in the prefrontal cortex and increased in the nucleus accumbens of rats predisposed to develop amphetamine self-administration

Cited by 311 publications

References 32 publications

Effects of the CRH Receptor Antagonist CP-154,526 on Intravenous Cocaine Self-administration in Rats

Effects of the CRH Receptor Antagonist CP-154,526 on Intravenous Cocaine Self-administration in Rats

Prenatal stress does not alter innate novelty-seeking behavioral traits, but differentially affects individual differences in neuroendocrine stress responsivity

The CCK-system underpins novelty-seeking behavior in the rat: Gene expression and pharmacological analyses

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