Dopaminergic agents affect the ability of brief periods of normal vision to prevent form-deprivation myopia

McCarthy, C. Siobhan; Megaw, Pam; Devadas, M.; Morgan, Ian G.

doi:10.1016/j.exer.2006.09.018

Cited by 175 publications

(200 citation statements)

References 35 publications

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“…Increased dopamine release has been shown to reduce axial elongation in chickens. 26 This postulated role of dopamine is supported by findings that a dopamine antagonist blocked the protective effect of bright light on axial elongation in another chicken model. 27 More recently in a primate model, high ambient lighting retarded development of form-deprivation myopia, supporting the earlier findings in chicken models, and suggesting that alteration of indoor light levels may be protective against myopia in humans.…”

supporting

confidence: 60%

The Association between Time Spent Outdoors and Myopia Using a Novel Biomarker of Outdoor Light Exposure

Sherwin

Hewitt

Coroneo

et al. 2012

Invest. Ophthalmol. Vis. Sci.

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1,5,6 PURPOSE. We sought to determine whether conjunctival ultraviolet autofluorescence (UVAF), a biomarker of outdoor light exposure, is associated with myopia.METHODS. We performed a cross-sectional study on Norfolk Island and recruited individuals aged ‡15 years. Participants completed a sun-exposure questionnaire and underwent noncycloplegic autorefraction. Conjunctival UVAF used a specially adapted electronic flash system fitted with UV-transmission filters (transmittance range 300-400 nm, peak 365 nm) as the excitation source. Temporal and nasal conjunctival UVAF was measured in both eyes using computerized photographic analysis with the sum referred to as ''total UVAF.'' RESULTS. In 636 participants, prevalence of myopia decreased with an increasing quartile of total UVAF (P trend ¼ 0.002). Median total UVAF was lower in subjects with myopia (spherical equivalent [SE] À1.0 diopter [D]) than participants without myopia: 16.6 mm 2 versus 28.6 mm 2 , P ¼ 0.001. In the multivariable model that adjusted for age, sex, smoking, cataract, height and weight, UVAF was independently associated with myopia (SE À1.0 D): odds ratio (OR) for total UVAF (per 10 mm 2 ) was 0.81, 95% confidence interval (CI) 0.69 to 0.94, P ¼ 0.007. UVAF was also significantly associated with myopia when analysis was restricted to subjects <50 years, and in moderate-severe myopia (SE À3.0 D). Prevalence of myopia decreased with increasing time outdoors (P trend ¼ 0.03), but time outdoors was not associated with myopia on multivariable analysis.CONCLUSIONS. Study authors identified a protective association between increasing UVAF and myopia. The protective association of higher UVAF against myopia was stronger than that of increased levels of time spent outdoors as measured by this study's questionnaire. Future studies should investigate the association between UVAF and incident myopia, and its relationship to myopic progression. (Invest Ophthalmol Vis Sci.

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supporting

confidence: 60%

The Association between Time Spent Outdoors and Myopia Using a Novel Biomarker of Outdoor Light Exposure

Sherwin

Hewitt

Coroneo

et al. 2012

Invest. Ophthalmol. Vis. Sci.

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“…The role of light intensity must also be considered. Since light is usually of greater intensity outdoors, eye exposure results in a more constricted pupil, increasing the depth of focus and leading to a less unfocused image [21].In addition, dopamine released by light stimulus on the retina can contribute directly to inhibiting ocular growth [21,22].…”

Section: Discussionmentioning

confidence: 99%

A Survey of the Prevalence of Refractive Errors among Children in Lower Primary Schools in Darnah City, Libya

Elmajri¹

2017

AOVS

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Introduction: Refractive error is a one of the most common problem among children which may lead to blindness. Refractive errors cannot be prevented, but they can be diagnosed early by a routine eye examination and treated with corrective glasses, contact lenses or refractive surgery.Objective: To determine the prevalence of refractive errors among school children attending lower primary school in Darnah city eastern part of Libya and the frequency of the various types of refractive errors, and their associated to selected demographic variables among school children. Materials and Methods:The research design adopted for this study was nonexperimental Descriptive in terms of analysis and Cross Sectional in terms of time frame. The study was conducted at selected school with 10 samples. The samples who met the inclusion criteria were selected by using convenient sampling technique. The tool used for the study was demographic variable and checklist to assess the factors associated with refractive error.Result: A total of 1000 children from 10 schools were randomly selected. However 920 were examined. Mean age of the students was 9.53±1.5. Refractive error was associated with female sex (107) one hundred seven children had a significant refractive error of ±0.50 or worse in one or both eyes, giving a prevalence of 11.6% and the commonest refractive error was hypermetropia which accounted for (57) 53.2% of all errors. This was followed by astigmatism with 34 (31.7%) children and myopia with 16 (14.9%). Conclusion:Refractive error needs careful evaluation and preventive care for children which leads to impaired quality of life and interfere with their daily lifestyle. Assessing the risk factor will help us to prevent and control the problem of refractive error in future generation which is helpful for the students to live a life problem free life. Keywords:

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“…22,23 A large body of experimental evidence supports the specific involvement of D2R in myopia development. [24][25][26] However, it is less clear whether or not D1R is involved in myopia development. Previously identified D1R involvement is based on pharmacology studies with chicken models of myopia.…”

mentioning

confidence: 99%

Bright Light Suppresses Form-Deprivation Myopia Development With Activation of Dopamine D1 Receptor Signaling in the ON Pathway in Retina

Chen

Zhi

Ruan

et al. 2017

Invest. Ophthalmol. Vis. Sci.

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Citation: Chen S, Zhi Z, Ruan Q, et al. Bright light suppresses form-deprivation myopia development with activation of dopamine D1 receptor signaling in the ON pathway in retina. Invest Ophthalmol Vis Sci. 2017;58:230658: -231658: . DOI:10.1167 PURPOSE. To determine whether dopamine receptor D1 (D1R) signaling pathway activation by bright light (BL) in specific retinal neuronal cell types contributes to inhibiting formdeprivation myopia (FDM) in mice.METHODS. Mice (3-weeks old) were raised under either normal light (NL: 100-200 lux) or BL (2500-5000 lux) conditions with or without form deprivation. Refraction changes were evaluated with an eccentric infrared photorefractor, and ocular axial components with optical coherence tomography. The D1R antagonist, SCH39166, was intraperitoneally injected daily to evaluate if BL mediates declines in FDM development through D1R activation. Six different biomarkers of retinal neuronal types delineated differential distribution of D1R expression. cFos and phosphorylated tyrosine hydroxylase (p-TH) immunofluorescent staining evaluated D1R receptor activation and dopamine synthesis, respectively. CONCLUSIONS. Bright light increases D1R activity in the BCs of the ON pathway, which is associated with less myopic shift and ocular elongation than those occurring in NL. These declines suggest that increased D1R activity in the ON pathway contributes to the BL suppression of FDM development in mice.

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Dopaminergic agents affect the ability of brief periods of normal vision to prevent form-deprivation myopia

Cited by 175 publications

References 35 publications

The Association between Time Spent Outdoors and Myopia Using a Novel Biomarker of Outdoor Light Exposure

The Association between Time Spent Outdoors and Myopia Using a Novel Biomarker of Outdoor Light Exposure

A Survey of the Prevalence of Refractive Errors among Children in Lower Primary Schools in Darnah City, Libya

Bright Light Suppresses Form-Deprivation Myopia Development With Activation of Dopamine D1 Receptor Signaling in the ON Pathway in Retina

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