Dopaminergic agonists for hepatic encephalopathy

Non-absorbable disaccharides for hepatic encephalopathy: systematic review of randomised trials

“…The review was performed according to a published protocol13 and reported according to the QUOROM statement 14…”

“…Included terms were “hepatic encephalopathy or cirrhosis”, and “lactulose, lactitol, or disaccharide”, and “random* or clinical” 13. We screened bibliographies of relevant articles and conference proceedings and wrote to experts and pharmaceutical companies.…”

“…Validity assessment —Two reviewers independently assessed trial quality15 16 by examining three components: generation of allocation sequence (classified as adequate if based on computer generated random numbers, tables of random numbers, or similar), concealment of allocation (classified as adequate if based on central randomisation, sealed envelopes, or similar), and blinding (classified as adequate if the trial was described as double blind or had blinded outcome assessment) 13. We classified trials with adequate concealment of allocation and adequate blinding as high quality.…”

The eating disorders medicine cabinet revisited: A clinician's guide to ipecac and laxatives

“…Consequently, it has been used to manage hepatic encephalopathy associated with liver failure, although its efficacy for this purpose is controversial. 62 Lactulose is generally well-tolerated, with flatulence, cramping, abdominal discomfort, nausea, and vomiting reported at typical dosages. Large dosages can cause diarrhea, fluid loss, hypokalemia, and hypernatremia.…”

Management of Hepatic Encephalopathy by Traditional Chinese Medicine

“…Clinical data showed that Narcon is helpful to improve the consciousness of HE patients. However, evidence has indicated that obvious variations exist in therapeutic effectiveness of these medicines on HE patients [41, 42]. …”