Dopaminergic Centers Neurodegeneration Biochemical and radiologic approach

Cuciureanu, Dan Iulian; Popescu, Roxana; Cuciureanu, Tudor; Constantinescu, Victor; Hodorog, Diana; Szalontay, Andreea Silvana

doi:10.37358/rc.19.5.7226

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…Most of these behavioral changes and cognitive disturbances are underdiagnosed and therefore, untreated in the early stages of PD. Patients with hyperdopaminergic state due to dopamine replacement therapy tend to be affected by another range of neuropsychiatric disorders, such as impulse control disorder, hallucinations, and psychosis (9,10).…”

Section: Introductionmentioning

confidence: 99%

Neuropsychiatric changes in Parkinson’s disease patients: A prospective observational two years study

Cuciureanu¹,

Croitoru²,

Constantinescu³

et al. 2019

Ro J Neurol.

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Parkinson's disease (PD) is clinically manifested by motor and non-motor symptoms, including neuropsychiatric changes, which can occur both in the early and advanced stages of PD. Objectives. The study evaluated cognitive and behavioral changes in patients with PD. Material and methods. Unified Parkinson's Disease Rating Scale (UPDRS) and Hoehn and Yahr scale were used to assess the neurological status of 112 patients with PD. Clinical neuropsychological tests were applied to all patients.Outcomes. The longer the duration of the disease is, the more critical impulse-control disorders are, especially shopping, hobbyism, and punding. Hypersexual behavior appears to be age and gender-dependent. Depression and impulse-control disorders seem interconnected: subjects tested with severe depression on the Hamilton Depression Rating Scale have more shopping compulsions. Antiparkinsonian treatment influences the Montreal Cognitive Assessment score. When specific cognitive domains are tested, subjects treated only with levodopa have lower scores at temporal and spatial orientation testing. Dopamine agonists appear to be associated with less cognitive dysfunctions. conclusions. Neuropsychiatric symptoms impact the quality of life in Parkinson's disease patients and must be systematically assessed.

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Section: Introductionmentioning

confidence: 99%

Neuropsychiatric changes in Parkinson’s disease patients: A prospective observational two years study

Cuciureanu¹,

Croitoru²,

Constantinescu³

et al. 2019

Ro J Neurol.

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Parkinson’s Disease in Romania: A Scoping Review

et al. 2021

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Parkinson’s disease (PD) is a significant cause of disability, with a fast-growing prevalence. This review summarizes the epidemiological and clinical data, research on the diagnostic approaches and the interventions available in the Eastern European country of Romania. This scoping review follows the recommendations on the scoping review methodology by Joanna Briggs Institute. We searched four databases (up to 27 January 2021). The data of eligible studies were extracted in standardized forms. We identified 149 unique studies from 1133 records, with 11 epidemiological studies, 52 studies investigating clinical aspects of PD, 35 studies on diagnostic tools, and 51 intervention studies. A narrative synthesis is provided and placed in a historical context. Our review revealed a considerable increase in the Romanian research on PD in the latest 15 years, which largely follows international trends. However, we also identified several research gaps that provide useful information for policymakers, public health specialists, and clinicians.

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Dopaminergic Centers Neurodegeneration Biochemical and radiologic approach

Cited by 2 publications

References 15 publications

Neuropsychiatric changes in Parkinson’s disease patients: A prospective observational two years study

Neuropsychiatric changes in Parkinson’s disease patients: A prospective observational two years study

Parkinson’s Disease in Romania: A Scoping Review

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